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Ketanserin

3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione · also: Taseron, ketensin, Serefrex, Perketal, Ketaserin, Ketanserine

FormulaC22H22FN3O3
Mol. weight395.4344
PubChem CID3822
InChIKeyFPCCSQOGAWCVBH-UHFFFAOYSA-N
SMILESC1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O
21,123Patents
3,659Research papers
1,433Patents - last 3 years
30Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Purdue Pharma LP359
2Boston Scientific Scimed Inc339
3Arena Pharmaceuticals Inc280
4Celgene Corp250
5Warsaw Orthopedic Inc212
6Janssen Pharmaceutica NV161
7Intra Cellular Therapies Inc156
8Siemens AG146
9F Hoffmann La Roche AG122
10University of California, San Diego120

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)11,025
2A61KMedicinal preparations9,656
3C07DHeterocyclic compounds6,540
4C07KPeptides1,357
5G01NInvestigating / analysing materials1,178
6A61LSterilising / disinfecting materials1,034
7C07CAcyclic and carbocyclic compounds1,017
8C08LPolymer compositions (blends)868
9C12NMicroorganisms, enzymes819
10Y02AClimate change adaptation618

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Synergistic compositions containing ketanserin1990Janssen Pharmaceutica NV27
Process for the dehydrogenative dimerization and/or polymerization of organic compounds with active hydrogen atoms using perketals1986Luperox GmbH7
Process for preparing ketanserine1984RAVIZZA S.p.A.6
Cyclic perketals and their use for cross-linking high density polyethylene1981ARGUS CHEMICAL CORPORATION6
Composition comprising ketanserin and L-carnitine or an alkanoyl L-carnitine for the treatment of CRPS2001Sigma Tau Industrie Farmaceutiche Riunite SpA2

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Neurotransmitter Receptor Influence on Behavior14
2Neuroscience and Neuropharmacology Research5
3Neuroscience of respiration and sleep5
4Receptor Mechanisms and Signaling5
5Cardiac electrophysiology and arrhythmias4
6Pain Mechanisms and Treatments4
7Psychedelics and Drug Studies4
8Asthma and respiratory diseases3
9Nicotinic Acetylcholine Receptors Study3
10Nitric Oxide and Endothelin Effects3

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Gitte M. KnudsenRigshospitalet26
2Adair R.S. SantosUniversidade Federal de Santa Catarina17
3Richard A. GlennonVirginia Commonwealth University Medical Center16
4Alberto J. KaumannHeinrich Heine University Düsseldorf12
5Ana Lúcia S. RodriguesUniversidade Federal de Santa Catarina12
6Claus SvarerCopenhagen University Hospital11
7A. AmeryKU Leuven10
8Guido MauraIstituto di Farmacologia Traslazionale5
9Lars H. PinborgRigshospitalet10
10Takafumi NagatomoNiigata University of Pharmacy and Medical and Life Sciences10

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Ketanserin?

Ketanserin has the molecular formula C22H22FN3O3 with a molecular weight of 395.4344. Its canonical IUPAC name is 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione, and it is also known by several brand names including Taseron, Serefrex, and Perketal.

Which organizations hold the most patents related to Ketanserin?

Purdue Pharma LP leads with 359 patents, followed by Boston Scientific Scimed Inc with 339 patents and Arena Pharmaceuticals Inc with 280 patents. Other significant patent holders include Celgene Corp, Warsaw Orthopedic Inc, and Janssen Pharmaceutica NV.

What are the primary research topics associated with Ketanserin studies?

The most significant research topics are Neurotransmitter Receptor Influence on Behavior, followed by Neuroscience and Neuropharmacology Research, Neuroscience of respiration and sleep, and Receptor Mechanisms and Signaling. Additional areas include Cardiac electrophysiology and arrhythmias, Pain Mechanisms and Treatments, and Psychedelics and Drug Studies.

What key patents describe Ketanserin's composition and synthesis?

Janssen Pharmaceutica NV patented synergistic compositions containing Ketanserin (EP-0391462-A1, 1990, 27 citations). RAVIZZA S.p.A. disclosed a process for preparing ketanserine (EP-0098499-A1, 1984, 6 citations). Sigma Tau Industrie Farmaceutiche Riunite SpA patented a composition of Ketanserin with L-carnitine for treating CRPS (US-6214884-B1, 2001, 2 citations).

What are the most cited foundational research papers on Ketanserin?

A 1982 paper titled "[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites" received 1079 citations and established receptor binding properties and functional role. A 1981 paper on the receptor binding profile of R 41 468 as a 5-HT2 receptor antagonist received 846 citations. These works focus on the compound's role in neurotransmitter receptor influence on behavior and receptor mechanisms.

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