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Dapsone

4-(4-aminophenyl)sulfonylaniline · also: Aczone, Dapson, Udolac, Eporal, Undolac, Dapsona

FormulaC12H12N2O2S
Mol. weight248.3
PubChem CID2955
InChIKeyMQJKPEGWNLWLTK-UHFFFAOYSA-N
SMILESC1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
101,214Patents
5,280Research papers
9,329Patents - last 3 years
98Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Toray Industries Inc3,765
2Resonac Corp2,895
3Kaneka Corp1,630
4Sumitomo Bakelite Co Ltd1,585
5Nippon Kayaku Co Ltd1,250
6Nissan Chemical Corp1,036
7Mitsui Chemicals Inc900
8Toyobo Co Ltd878
9General Electric Co858
10SABIC Global Technologies BV846

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C08GPolymers from non-vinyl bonds (e.g. polyamides, polyesters)27,884
2C08LPolymer compositions (blends)23,983
3A61KMedicinal preparations21,739
4A61PTherapeutic activity (drug indications)19,715
5C08KPolymer compositions (additives)13,576
6C08JWorking-up of plastics12,012
7Y10TCross-reference (technical subjects)8,425
8C07DHeterocyclic compounds8,197
9C09DCoatings, paints, varnishes7,282
10B32BLayered products7,241

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Dapsone and promin for the treatment of dementia1996THE UNIVERSITY OF BRITISH COLUMBIA29
COMBINATION OF DAPSONE WITH ADAPALENE2011Allergan Inc18
DAPSONE TO TREAT ROSASCEA2009Tolmar Therapeutics Inc13
Emulsifying composition containing dapsone2007キューエルティー・ユーエスエイ・インコーポレーテッド12
EMULSIVE COMPOSITION CONTAINING DAPSONE2005Tolmar Therapeutics Inc10

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Leprosy Research and Treatment45
2Autoimmune Bullous Skin Diseases28
3Pneumocystis jirovecii pneumonia detection and treatment10
4Methemoglobinemia and Tumor Lysis Syndrome8
5Autoimmune and Inflammatory Disorders7
6Blood disorders and treatments7
7Celiac Disease Research and Management7
8Acne and Rosacea Treatments and Effects6
9Drug-Induced Adverse Reactions6
10Malaria Research and Control6

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Michael D. ColemanAston University21
2Takashi HashimotoKurume University21
3R. J. W. ReesNational Institute for Medical Research17
4Michael F. WatersUnited States Public Health Service15
5Brian GreenwoodMRC Unit the Gambia13
6A GirdharNational JALMA Institute for Leprosy & Other Mycobacterial Diseases12
7A. C. McDOUGALLUniversity of Oxford12
8G RamuNational JALMA Institute for Leprosy & Other Mycobacterial Diseases12
9S Balakrishnan12
10A. B. G. LaingMRC Unit the Gambia11

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition and molecular structure of Dapsone?

Dapsone has the chemical name 4-(4-aminophenyl)sulfonylaniline with the molecular formula C12H12N2O2S and a molecular weight of 248.3. The InChI key is MQJKPEGWNLWLTK-UHFFFAOYSA-N.

What are the primary clinical research areas associated with Dapsone?

The primary research areas include Leprosy Research and Treatment, Autoimmune Bullous Skin Diseases, and Pneumocystis jirovecii pneumonia detection and treatment. Additional research topics cover Methemoglobinemia and Tumor Lysis Syndrome, Autoimmune and Inflammatory Disorders, and Acne and Rosacea Treatments and Effects.

What are examples of recent patent applications for Dapsone formulations?

Recent patents include a combination of Dapsone with Adapalene filed by Allergan Inc in 2011, Dapsone to treat rosacea by Tolmar Therapeutics Inc in 2009, an emulsifying composition containing Dapsone by Tolmar Therapeutics Inc in 2005, and an emulsifying composition containing Dapsone in 2007.

Which organizations have published significant research on Dapsone?

Leading researchers include Michael D. Coleman from Aston University with 21 papers, and R. J. W. Rees from National Institute for Medical Research with 17 papers. A Girdhar and G Ramu from National JALMA Institute for Leprosy & Other Mycobacterial Diseases each have 12 papers. Brian Greenwood and A. B. G. Laing from MRC Unit the Gambia have 13 and 11 papers respectively.

How has patent activity for compounds related to Dapsone evolved in recent years?

Patent activity shows an increasing trend, with 3,768 patents in 2016 rising to 4,890 in 2023. The most recent complete year 2024 recorded 4,754 patents. In the last three years (2022-2024), there were 14,422 patents total. Paper publications have remained relatively stable, with 81 papers in 2016 declining to 41 in 2024, with 98 papers published in the last three years.

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