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Aczone

4-(4-aminophenyl)sulfonylaniline · also: Eporal, Normet, Dapson, Udolac, Undolac, Diphone

FormulaC12H12N2O2S
Mol. weight248.3
PubChem CID2955
InChIKeyMQJKPEGWNLWLTK-UHFFFAOYSA-N
SMILESC1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
101,214Patents
5,280Research papers
9,676Patents - last 3 years
98Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Toray Industries Inc3,765
2Resonac Corp2,895
3Kaneka Corp1,630
4Sumitomo Bakelite Co Ltd1,585
5Nippon Kayaku Co Ltd1,250
6Nissan Chemical Corp1,036
7Mitsui Chemicals Inc879
8Toyobo Co Ltd878
9General Electric Co858
10SABIC Global Technologies BV841

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C08GPolymers from non-vinyl bonds (e.g. polyamides, polyesters)27,879
2C08LPolymer compositions (blends)23,977
3A61KMedicinal preparations21,739
4A61PTherapeutic activity (drug indications)19,714
5C08KPolymer compositions (additives)13,573
6C08JWorking-up of plastics12,010
7Y10TCross-reference (technical subjects)8,425
8C07DHeterocyclic compounds8,196
9C09DCoatings, paints, varnishes7,273
10B32BLayered products7,239

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Dapsone and promin for the treatment of dementia1996THE UNIVERSITY OF BRITISH COLUMBIA29
COMBINATION OF DAPSONE WITH ADAPALENE2011Allergan Inc18
DAPSONE TO TREAT ROSASCEA2009Tolmar Therapeutics Inc13
Emulsifying composition containing dapsone2007キューエルティー・ユーエスエイ・インコーポレーテッド12
EMULSIVE COMPOSITION CONTAINING DAPSONE2005Tolmar Therapeutics Inc10

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Leprosy Research and Treatment39
2Autoimmune Bullous Skin Diseases24
3Pneumocystis jirovecii pneumonia detection and treatment10
4Methemoglobinemia and Tumor Lysis Syndrome8
5Autoimmune and Inflammatory Disorders7
6Blood disorders and treatments6
7Celiac Disease Research and Management6
8Acne and Rosacea Treatments and Effects5
9Chronic Lymphocytic Leukemia Research5
10Drug-Induced Adverse Reactions5

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Michael D. ColemanAston University21
2Takashi HashimotoKurume University21
3R. J. W. ReesNational Institute for Medical Research17
4Michael F. WatersUnited States Public Health Service15
5Brian GreenwoodMRC Unit the Gambia13
6A GirdharNational JALMA Institute for Leprosy & Other Mycobacterial Diseases12
7A. C. McDOUGALLUniversity of Oxford12
8G RamuNational JALMA Institute for Leprosy & Other Mycobacterial Diseases12
9S Balakrishnan12
10A. B. G. LaingNational Institute for Medical Research10

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition of Aczone?

Aczone has the molecular formula C12H12N2O2S with a molecular weight of 248.3. Its canonical chemical name is 4-(4-aminophenyl)sulfonylaniline, and it is also known by many synonyms including dapsone, which is among the most commonly used alternate names.

What are the primary medical research areas associated with Aczone?

The compound is most extensively studied in Leprosy Research and Treatment, which accounts for 37 papers in the covered literature. Other significant research areas include Autoimmune Bullous Skin Diseases (23 papers), Pneumocystis jirovecii pneumonia detection and treatment (10 papers), and Methemoglobinemia and Tumor Lysis Syndrome (8 papers).

What are some notable patent applications for Aczone-based formulations?

Recent patent filings include a combination of Aczone with adapalene (2011), an emulsifying composition containing dapsone (2007), treatment of rosacea with dapsone (2009), and early work on dapsone and promin for dementia treatment (1996). Allergan Inc and Tolmar Therapeutics Inc are among the assignees active in this space.

Which researchers have published most extensively on Aczone?

Leading authors in the field include Michael D. Coleman from Aston University and Takashi Hashimoto from Kurume University, each with 21 papers. R. J. W. Rees from the National Institute for Medical Research has authored 17 papers, and Michael F. Waters from the United States Public Health Service has published 15 papers on the compound.

What is the current patent activity level for Aczone-related inventions?

The aggregate database contains 101,214 total patents related to Aczone across all time periods, with 9,919 patents filed in the last three years. Recent years show sustained patent activity, with 4,778 patents in 2022 and 4,890 in 2023. Academic publications show a declining trend, with 98 papers published in the last three years compared to higher publication rates in earlier periods.

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