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Avapro

2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one · also: Karvea, Aprovel, Irbetan, Avalide, Sabervel, Sarbevel

FormulaC25H28N6O
Mol. weight428.54
PubChem CID3749
InChIKeyYOSHYTLCDANDAN-UHFFFAOYSA-N
SMILESCCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5
36,387Patents
2,080Research papers
2,430Patents - last 3 years
71Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck Sharp & Dohme LLC1,934
2Bristol Myers Squibb Co1,592
3Takeda Pharmaceutical Co Ltd1,494
4Novartis AG1,218
5Boehringer Ingelheim International GmbH741
6Gilead Sciences Inc519
7AstraZeneca AB494
8Organon Pharma UK Ltd456
9F Hoffmann La Roche AG374
10Bayer Pharma AG354

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)30,210
2A61KMedicinal preparations25,837
3C07DHeterocyclic compounds17,297
4C07KPeptides3,476
5C07CAcyclic and carbocyclic compounds2,747
6Y02AClimate change adaptation1,908
7C12NMicroorganisms, enzymes1,564
8G01NInvestigating / analysing materials1,539
9C07BGeneral methods of organic chemistry1,342
10C07FOrganometallic compounds1,112

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Avapro dispersible tablet and preparation method thereof2010BEIJING YILING BIOENGINEERING CO., LTD.8
Avapro dispersible tablet and preparation method thereof2013BEIJING YILING BIOLOGICAL ENGINEERING TECHNOLOGY CO.,LTD.0
Aprovel1998SANOFI0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Blood Pressure and Hypertension Studies16
2Renin-Angiotensin System Studies8
3Heart Failure Treatment and Management6
4Renal Diseases and Glomerulopathies4
5Receptor Mechanisms and Signaling3
6Atrial Fibrillation Management and Outcomes2
7Cardiovascular Health and Disease Prevention2
8Drug-Induced Hepatotoxicity and Protection2
9Hormonal Regulation and Hypertension2
10Inflammatory mediators and NSAID effects2

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Andrew PalmerCenter for Outcomes Research and Clinical Epidemiology16
2Thomas KahanKarolinska Institutet15
3A.H. Jan DanserErasmus University Rotterdam14
4Hans‐Henrik ParvingAarhus University14
5Peter BramlageTechnische Universität Dresden14
6Karin MalmqvistKarolinska Institutet13
7Agata PtaszynskaBristol-Myers Squibb (United States)12
8John J.V. McMurrayUniversity of Glasgow12
9Michel BurnierHôpital Orthopédique de la Suisse Romande12
10Michael R. ZileMedical University of South Carolina9

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Avapro?

Avapro has the molecular formula C25H28N6O with a molecular weight of 428.54. Its canonical chemical name is 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one.

Which organizations hold the most patents related to Avapro?

The leading patent assignees in the Avapro field are Merck Sharp and Dohme LLC with 1934 patents, Bristol Myers Squibb Co with 1592 patents, and Takeda Pharmaceutical Co Ltd with 1494 patents.

What are the primary research topics associated with Avapro?

The dominant research areas are Blood Pressure and Hypertension Studies with 16 papers, followed by Renin-Angiotensin System Studies with 8 papers and Heart Failure Treatment and Management with 5 papers.

Which landmark studies on Avapro have received the highest citations?

The most cited paper is "Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes" from 2001 with 5997 citations, followed by "The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes" also from 2001 with 2891 citations.

What patent classification codes dominate Avapro-related intellectual property?

The most prevalent CPC subclass is A61P (pharmaceutical preparations classified by application) with 30209 patents, followed by A61K (pharmaceutical formulations and preparations) with 25833 patents, and C07D (heterocyclic compounds) with 17296 patents.

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