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Humex

2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid · also: vidix, Setir, Cetryn, Ziptek, Zirtek, Xarlin

FormulaC21H25ClN2O3
Mol. weight388.892
PubChem CID2678
InChIKeyZKLPARSLTMPFCP-UHFFFAOYSA-N
SMILESC1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
36,542Patents
1,874Research papers
2,782Patents - last 3 years
59Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1AstraZeneca AB1,110
2Merck Sharp & Dohme LLC1,096
3Novartis AG1,052
4Boehringer Ingelheim International GmbH867
5Glaxo Group Ltd757
6Procter and Gamble Co512
7Massachusetts Institute of Technology504
8Kenvue Brands LLC425
9AbbVie Inc419
10Ono Pharmaceutical Co Ltd353

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)25,864
2A61KMedicinal preparations25,376
3C07DHeterocyclic compounds13,716
4C07KPeptides3,597
5C12NMicroorganisms, enzymes2,297
6A61MDevices for introducing media into the body2,153
7Y02AClimate change adaptation1,971
8C07CAcyclic and carbocyclic compounds1,930
9G01NInvestigating / analysing materials1,387
10A61QCosmetics, personal care1,200

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Allergic Rhinitis and Sensitization20
2Asthma and respiratory diseases7
3Dermatology and Skin Diseases4
4Urticaria and Related Conditions4
5Analytical Methods in Pharmaceuticals3
6Drug-Induced Adverse Reactions3
7Analytical Chemistry and Chromatography2
8Cardiac electrophysiology and arrhythmias2
9Drug Transport and Resistance Mechanisms2
10Mast cells and histamine2

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1J.‐P. RihouxUCB Pharma (Belgium)18
2Giorgio CiprandiOspedale Policlinico San Martino11
3F. Estelle R. SimonsUniversity of Manitoba9
4Giorgio Walter CanonicaUniversity of Genoa10
5Bernard BurtinUCB Pharma (Belgium)9
6Garry M. WalshUniversity of Aberdeen6
7Andrew M. WilsonUniversity of Dundee5
8Annemiek VermeerenMaastricht University5
9Antonio ValeroHospital Clínic de Barcelona5
10Ashok PurohitInserm5

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition and molecular structure of Humex?

Humex has the canonical chemical name 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid, with the molecular formula C21H25ClN2O3 and a molecular weight of 388.892. It is known by multiple trade names and synonyms including Zyrtec, cetirizine, and Reactine.

Which organizations hold the most patents related to Humex?

The leading patent assignees for Humex-related compounds are AstraZeneca AB with 1110 patents, Merck Sharp and Dohme LLC with 1096 patents, and Novartis AG with 1052 patents. Other major assignees include Boehringer Ingelheim International GmbH, Glaxo Group Ltd, and Procter and Gamble Co.

What are the primary research topics associated with Humex in the scientific literature?

The dominant research area is Allergic Rhinitis and Sensitization, with 18 papers. Other significant topics include Asthma and respiratory diseases, Dermatology and Skin Diseases, and Urticaria and Related Conditions. Additional specialized topics cover analytical methods, adverse reactions, and mast cell biology.

Who are the most prolific researchers publishing on Humex and related topics?

J.‐P. Rihoux from UCB Pharma (Belgium) has authored 18 papers on this compound. Giorgio Ciprandi from Ospedale Policlinico San Martino has 11 papers, and Giorgio Walter Canonica from University of Genoa has 10 papers. F. Estelle R. Simons from University of Manitoba and Bernard Burtin from UCB Pharma (Belgium) are also significant contributors.

How has research and patent activity related to Humex changed in recent years?

Patent filings have declined from a peak of 1538 in 2016 to 1307 in 2024, with 768 patents filed through mid-2025. Scientific papers show a general declining trend from 44 in 2019 to 31 in 2024, though with some variability. In the last 3 years, there were 2835 patents and 59 papers filed.

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