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Cetirizine

2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid · also: Setir · Humex · Ziptek · Virlix · Zyrlex · Zirtek

FormulaC21H25ClN2O3
Mol. weight388.892
PubChem CID2678
InChIKeyZKLPARSLTMPFCP-UHFFFAOYSA-N
SMILESC1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
36,542Patents
1,874Research papers1,875 indexed in detail
2,580Patents - last 3 years
59Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck and Co Inc1,463
2AstraZeneca PLC1,182
3C.H. Boehringer Sohn AG and Co KG1,054
4Novartis AG1,052
5GSK PLC860
6Pfizer Inc553
7Procter and Gamble Co537
8AbbVie Inc535
9Massachusetts Institute of Technology524
10Kenvue Inc461

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)25,870
2A61KMedicinal preparations25,377
3C07DHeterocyclic compounds13,716
4C07KPeptides3,597
5C12NMicroorganisms, enzymes2,297
6A61MDevices for introducing media into the body2,153
7Y02AClimate change adaptation1,972
8C07CAcyclic and carbocyclic compounds1,930
9G01NInvestigating / analysing materials1,391
10A61QCosmetics, personal care1,200

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Combination dosage form comprising cetirizine and pseudoephedrine2001Kenvue Inc60
Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants2002Sumitomo Chemical Co Ltd45
Solid, rapidly disintegrating cetirizine formulations2001Viatris Inc43
CETIRIZINE-CONTAINING COMPOSITION FOR ANTIALLERGIC EYE DROP AND NASAL DROP1994Senju Pharmaceutical Co Ltd40
Methods for treating allergic disorders using optically pure (-) cetirizine1997Sumitomo Chemical Co Ltd39

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
201635
201738
201833
201944
202043
202128
202231
202318
202431
202510

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1J.‐P. RihouxUCB Pharma (Belgium)18
2Martin K. ChurchSouthampton General Hospital16
3Bernard BurtinUCB Pharma (Belgium)12
4Giorgio CiprandiOspedale Policlinico San Martino11
5Giorgio Walter CanonicaUniversity of Genoa10
6Torsten ZuberbierCharité - Universitätsmedizin Berlin9
7F. Estelle R. SimonsUniversity of Manitoba8
8Maria Angela ToscaUniversity of Genoa7
9Timo ReunalaTampere University Hospital7
10M. Strolin BenedettiUCB Pharma (France)7

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of cetirizine?

Cetirizine has the molecular formula C21H25ClN2O3 with a molecular weight of 388.892. Its canonical chemical name is 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid, and it is also known by the InChI Key ZKLPARSLTMPFCP-UHFFFAOYSA-N.

Which organizations have the most patent activity related to cetirizine?

The leading patent assignees for cetirizine are Merck and Co Inc with 1463 patents, AstraZeneca PLC with 1182 patents, C.H. Boehringer Sohn AG and Co KG with 1054 patents, and Novartis AG with 1052 patents.

What are the most cited patent applications for cetirizine formulations?

Notable cetirizine patents include a combination dosage form comprising cetirizine and pseudoephedrine with 60 citations, methods and compositions using cetirizine with leukotriene inhibitors or decongestants with 45 citations, and solid rapidly disintegrating cetirizine formulations with 43 citations.

What research topics dominate the scientific literature on cetirizine?

Key research areas include allergic rhinitis, asthma and respiratory diseases, and dermatology applications such as urticaria treatment. A highly-cited paper on allergic rhinitis has 586 citations, while a study on the effectiveness of levocetirizine and desloratadine in urticaria treatment has 329 citations.

How has cetirizine patent filing activity trended in recent years?

Patent filings related to cetirizine showed a peak of 1539 in 2016, followed by a general declining trend through 2021 (1193 patents), with a slight recovery in 2022-2023 (1210 and 1319 patents respectively). In 2024, there were 1307 patents filed. In the last 3 years, there have been 2580 patents filed total.

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