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Cocaine

methyl (1R,2R,3S,5S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate · also: Blast, Snort, Crack, Cecil, Kokan, Flake

FormulaC17H21NO4
Mol. weight303.358
PubChem CID446220
InChIKeyZPUCINDJVBIVPJ-LJISPDSOSA-N
SMILESCN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)OC
65,349Patents
36,219Research papers
5,637Patents - last 3 years
850Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Dexcom Inc1,260
2Merck Sharp & Dohme LLC1,210
3Pfizer Inc837
4Glaxo Group Ltd828
5F Hoffmann La Roche AG785
6Organon Pharma UK Ltd652
7Pfizer Corp SRL639
8Janssen Pharmaceutica NV627
9NTG Nordic Transport Group AS586
10Pfizer Products Inc564

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)36,706
2A61KMedicinal preparations32,475
3C07DHeterocyclic compounds20,710
4G01NInvestigating / analysing materials8,564
5C07KPeptides4,639
6A61B4,284
7Y02AClimate change adaptation3,493
8C12NMicroorganisms, enzymes3,478
9C07CAcyclic and carbocyclic compounds3,256
10A61MDevices for introducing media into the body2,555

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Treatment for cocaine abuse1991THE MCLEAN HOSPITAL CORPORATION250
Treatment of cocaine addiction1993MATRIX TECHNOLOGIES, INC.102
COCAINE RECEPTOR BINDING LIGANDS1992RESEARCH TRIANGLE INSTITUTE77
Cocaine receptor binding ligands1995United States Department of Health and Human Services69
Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds polypeptide and derivatives thereof1977Syva Co64

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Neurotransmitter Receptor Influence on Behavior301
2Forensic Toxicology and Drug Analysis136
3Substance Abuse Treatment and Outcomes76
4Prenatal Substance Exposure Effects74
5Neuroscience and Neuropharmacology Research43
6Opioid Use Disorder Treatment29
7Cannabis and Cannabinoid Research26
8HIV, Drug Use, Sexual Risk21
9Attention Deficit Hyperactivity Disorder20
10HIV Research and Treatment13

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Eric J. NestlerIcahn School of Medicine at Mount Sinai146
2Peter W. KalivasMedical University of South Carolina141
3Thomas R. KostenYale University139
4Nora D. VolkowBrookhaven National Laboratory130
5Amy Hauck NewmanNational Institute on Drug Abuse111
6George F. KoobScripps Research Institute98
7Jonathan L. KatzNational Institute on Drug Abuse97
8F. Ivy CarrollRTI International95
9Mary Jeanne KreekRockefeller University79
10Michael A. NaderWake Forest University77

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and structure of cocaine?

Cocaine has the molecular formula C17H21NO4 with a molecular weight of 303.358. Its canonical IUPAC name is methyl (1R,2R,3S,5S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate, and its InChI Key is ZPUCINDJVBIVPJ-LJISPDSOSA-N.

Which research topics dominate the scientific literature on cocaine?

The most prominent research topic is Neurotransmitter Receptor Influence on Behavior with 301 papers, followed by Forensic Toxicology and Drug Analysis with 136 papers, and Substance Abuse Treatment and Outcomes with 76 papers.

What are the most productive patent assignees in the cocaine-related patent landscape?

The leading patent assignees are Dexcom Inc with 1260 patents, Merck Sharp & Dohme LLC with 1210 patents, and Pfizer Inc with 837 patents.

What are the key historical patents addressing cocaine treatment and analysis?

Notable patents include Treatment for cocaine abuse (1991) assigned to THE MCLEAN HOSPITAL CORPORATION with 250 citations, Treatment of cocaine addiction (1993) assigned to MATRIX TECHNOLOGIES, INC. with 102 citations, and COCAINE RECEPTOR BINDING LIGANDS (1992) assigned to RESEARCH TRIANGLE INSTITUTE with 77 citations.

Who are the most prolific authors in cocaine research?

Leading researchers include Eric J. Nestler from Icahn School of Medicine at Mount Sinai with 146 papers, Peter W. Kalivas from Medical University of South Carolina with 141 papers, and Thomas R. Kosten from Yale University with 139 papers.

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