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Akbeta

5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one · also: Betagan, Bunolol, beta-site, levobunololo, Levobunololum, ApoLevobunolol

FormulaC17H25NO3
Mol. weight291.391
PubChem CID39468
InChIKeyIXHBTMCLRNMKHZ-LBPRGKRZSA-N
SMILESCC(C)(C)NC[C@@H](COC1=CC=CC2=C1CCCC2=O)O
14,293Patents
292Research papers
847Patents - last 3 years
4Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Allergan Inc452
2Theravance Biopharma R&D IP LLC234
3Merck Sharp & Dohme LLC220
4Merck and Co Inc219
5Purdue Pharma LP194
6Alcon Inc189
7Euro Celtique SA185
8AstraZeneca AB151
9Novartis AG141
10Santen Pharmaceutical Co Ltd116

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)10,377
2A61KMedicinal preparations9,464
3C07DHeterocyclic compounds4,571
4C07KPeptides1,459
5A61F1,412
6C07CAcyclic and carbocyclic compounds1,210
7A61MDevices for introducing media into the body803
8C12NMicroorganisms, enzymes767
9G01NInvestigating / analysing materials731
10A61LSterilising / disinfecting materials639

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Indole beta-site alkylation method without participation of transition metal2021JIANGSU UNIVERSITY OF SCIENCE AND TECHNOLOGY1
A-pi-D type donor photovoltaic material formed by connecting porphyrin single beta site through double bonds, and preparation and application thereof2023SOUTH CHINA UNIVERSITY OF TECHNOLOGY0
COMPOUNDS AND THEIR USE AS BETA SITE APP CLEAVING ENZYME (BACE) INHIBITORS2017ASTRAZENECA AB0
IMINOTIADIAZINE DIOXIDE COMPOUNDS AS BETA SITE APP DISOCIATION ENZYME INHIBITORS (BACE), COMPOSITIONS, AND ITS USE2017MERCK SHARP & DOHME CORP0
PROCEDURE FOR PREPARING FOR THE ALFA. BETA SITE ETHENICALLY UNSATURATED CARBOCYCLIC KETONES FROM ENOLLACTONES.1975SYNTEX CORPORATION, PANAMA.0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Glaucoma and retinal disorders6
2Autoimmune Bullous Skin Diseases1
3Non-Invasive Vital Sign Monitoring1
4Ocular Surface and Contact Lens1
5Poisoning and overdose treatments1
6Receptor Mechanisms and Signaling1
7Retinal Diseases and Treatments1
8Urinary Bladder and Prostate Research1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Gary D. NovackUniversity of California, Irvine28
2Efraim DuzmanUniversity of California, Irvine9
3Elaine P. KelleyAllergan (United States)9
4Franz-Josef LeinweberWake Forest University7
5John LueAllergan (United States)7
6Diane Tang‐LiuAllergan (Ireland)5
7Frederick J. Di CarloWake Forest University5
8Hideaki KohriOtsuka (Japan)5
9Kwou‐Yeung WuKaohsiung Medical University5
10Charles F. Schwender4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Akbeta?

Akbeta has the molecular formula C17H25NO3 and a molecular weight of 291.391 g/mol. Its canonical name is 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one, and it is also known by several synonyms including Betagan, Bunolol, and levobunolol hydrochloride.

Which companies hold the most patents related to this compound?

The leading patent assignees in this field are Allergan Inc with 452 patents, Theravance Biopharma R&D IP LLC with 234 patents, Merck Sharp and Dohme LLC with 220 patents, and Merck and Co Inc with 219 patents. Other significant assignees include Purdue Pharma LP, Alcon Inc, and Euro Celtique SA.

What research topics are most associated with Akbeta in the academic literature?

The dominant research topic associated with Akbeta is Glaucoma and retinal disorders, which accounts for 5 papers in the corpus. Other topics represented include Non-Invasive Vital Sign Monitoring, Ocular Surface and Contact Lens, Autoimmune Bullous Skin Diseases, and Receptor Mechanisms and Signaling, each with one paper.

Who are the most prolific authors in Akbeta research?

Gary D. Novack from University of California, Irvine is the leading author with 28 papers on this compound. Other active researchers include Efraim Duzman and Elaine P. Kelley, each with 9 papers. Elaine P. Kelley is affiliated with Allergan (United States), while additional contributors include Franz-Josef Leinweber, John Lue, and Diane Tang‐Liu.

What is the distribution of patents by CPC classification for this compound?

The most common CPC subclasses are A61P (pharmaceutical preparations for specific therapeutic activities) with 10,377 patents, and A61K (preparations for medical, dental, or toilet purposes) with 9,464 patents. Other significant classifications include C07D (heterocyclic compounds with 4,571 patents), C07K (organic compounds with 1,459 patents), and A61F (filters, medical devices with 1,409 patents).

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