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Levobunolol

5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one · also: beta-site, (-)-Bunolol, levobunololo, Bunolol, (s)-, Levobunololum, Bunolol, (-)-

FormulaC17H25NO3
Mol. weight291.391
PubChem CID39468
InChIKeyIXHBTMCLRNMKHZ-LBPRGKRZSA-N
SMILESCC(C)(C)NC[C@@H](COC1=CC=CC2=C1CCCC2=O)O
14,293Patents
292Research papers
824Patents - last 3 years
4Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Allergan Inc452
2Theravance Biopharma R&D IP LLC234
3Merck Sharp & Dohme LLC220
4Merck and Co Inc218
5Purdue Pharma LP194
6Alcon Inc189
7Euro Celtique SA185
8AstraZeneca AB151
9Novartis AG141
10Santen Pharmaceutical Co Ltd116

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)10,377
2A61KMedicinal preparations9,464
3C07DHeterocyclic compounds4,571
4C07KPeptides1,459
5A61F1,412
6C07CAcyclic and carbocyclic compounds1,210
7A61MDevices for introducing media into the body803
8C12NMicroorganisms, enzymes767
9G01NInvestigating / analysing materials731
10A61LSterilising / disinfecting materials639

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Application of the Levobunolol Hydrochorid in preparing medicament for resisting Eimeria tenella2018Guangzhou Huixin Animal Pharmaceutical Co. Ltd.2
Indole beta-site alkylation method without participation of transition metal2021JIANGSU UNIVERSITY OF SCIENCE AND TECHNOLOGY1
Preparation method of levobunolol hydrochloride2021Hangzhou Normal University0
A kind of preparation method of Levobunolol Hydrochorid2019Hangzhou Normal University0
Instant gel rubber of levobunolol hcl for eyes2009XIAO ZHENGLIAN0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Glaucoma and retinal disorders8
2Autoimmune Bullous Skin Diseases1
3Non-Invasive Vital Sign Monitoring1
4Ocular Surface and Contact Lens1
5Poisoning and overdose treatments1
6Receptor Mechanisms and Signaling1
7Retinal Diseases and Treatments1
8Urinary Bladder and Prostate Research1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Gary D. NovackUniversity of California, Irvine28
2Efraim DuzmanUniversity of California, Irvine9
3Elaine P. KelleyAllergan (United States)9
4Franz-Josef LeinweberWake Forest University7
5John LueAllergan (United States)7
6Diane Tang‐LiuAllergan (Ireland)5
7Frederick J. Di CarloWake Forest University5
8Hideaki KohriOtsuka (Japan)5
9Kwou‐Yeung WuKaohsiung Medical University5
10Charles F. Schwender4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Levobunolol?

Levobunolol has the molecular formula C17H25NO3 and a molecular weight of 291.391 g/mol.

Which companies hold the most patents involving Levobunolol?

The top patent assignees for Levobunolol are Allergan Inc with 452 patents, Theravance Biopharma R&D IP LLC with 234 patents, and Merck Sharp & Dohme LLC with 220 patents.

What are the primary research topics associated with Levobunolol publications?

The primary research topic is Glaucoma and retinal disorders, which accounts for 8 papers. Other associated topics include Retinal Diseases and Treatments, Ocular Surface and Contact Lens, and Receptor Mechanisms and Signaling, each with 1 paper.

What is the patent filing trend for Levobunolol in recent years?

Patent filings peaked in 2016 with 755 patents and have generally declined since, with 405 patents filed in 2024 and only 217 in 2025. In the last 3 years, 824 patents have been filed in total.

Which researcher has published the most papers on Levobunolol?

Gary D. Novack from University of California, Irvine has published 28 papers, the highest count among all authors associated with Levobunolol research.

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