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Levobunolol

5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one · also: beta-site · (-)-Bunolol · levobunololo · Levobunololum · ApoLevobunolol · PMSLevobunolol

FormulaC17H25NO3
Mol. weight291.391
PubChem CID39468
InChIKeyIXHBTMCLRNMKHZ-LBPRGKRZSA-N
SMILESCC(C)(C)NC[C@@H](COC1=CC=CC2=C1CCCC2=O)O
14,293Patents
292Research papers291 indexed in detail
781Patents - last 3 years
4Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck and Co Inc541
2Johnson and Johnson502
3AbbVie Inc452
4Roche Holding AG309
5Alcon Inc298
6Theravance Biopharma Inc266
7Purdue Pharma LP239
8Euro Celtique SA206
9AstraZeneca PLC202
10Pfizer Inc201

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)10,381
2A61KMedicinal preparations9,467
3C07DHeterocyclic compounds4,571
4C07KPeptides1,459
5A61F1,412
6C07CAcyclic and carbocyclic compounds1,210
7A61MDevices for introducing media into the body803
8C12NMicroorganisms, enzymes768
9G01NInvestigating / analysing materials731
10A61LSterilising / disinfecting materials639

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Application of the Levobunolol Hydrochorid in preparing medicament for resisting Eimeria tenella20182
Indole beta-site alkylation method without participation of transition metal20211
Preparation method of levobunolol hydrochloride2021Hangzhou Normal University0
A kind of preparation method of Levobunolol Hydrochorid2019Hangzhou Normal University0
Instant gel rubber of levobunolol hcl for eyes20090

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20162
20172
20222
20233
20241

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Gary D. NovackUniversity of California, Irvine27
2Elaine P. KelleyAllergan (United States)9
3Franz-Josef LeinweberWake Forest University6
4Hideaki KohriOtsuka (Japan)5
5Kwou‐Yeung WuKaohsiung Medical University5
6M. OberPraxis für Humangenetik4
7Hwei‐Zu WangKaohsiung Medical University Chung-Ho Memorial Hospital4
8Seiji MoritaOtsuka (Japan)4
9Charles F. Schwender4
10KAZUYUKI NAKAGAWA4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of levobunolol?

Levobunolol has the molecular formula C17H25NO3 with a molecular weight of 291.391 Da. Its canonical chemical name is 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one.

Which companies hold the most patents related to levobunolol?

The leading patent assignees are Merck and Co Inc with 541 patents, Johnson and Johnson with 502 patents, and AbbVie Inc with 452 patents. Alcon Inc holds 298 patents and Roche Holding AG holds 309 patents in this space.

What is the patent filing trend for levobunolol-related inventions in recent years?

Patent filings show a declining trend since 2017. After peaking at 767 filings in 2017, the count decreased to 584 in 2018, 545 in 2019, and further to 400–405 annually in 2022–2024. In 2025, only 217 filings were recorded with 34 in 2026 (likely incomplete data).

What are the primary research topics associated with levobunolol in academic literature?

Published papers on levobunolol focus on glaucoma and retinal disorders. Notable papers include studies on test-retest reliability of contrast testing in glaucoma therapy, intraocular pressure changes after cataract surgery, and allergic reactions to related compounds used in glaucoma treatment.

Which patent classifications dominate levobunolol-related filings?

The leading CPC subclasses are A61P (pharmaceutical preparations for diagnosis or disease treatment) with 10,381 patents, A61K (preparations for medical purposes) with 9,467 patents, and C07D (heterocyclic compounds) with 4,571 patents. These reflect the compound's pharmaceutical and chemical synthesis focus.

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