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Acuco

5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine · also: Comox, Bacin, Ipral, Bacta, Cidal, Nopil

FormulaC14H18N4O3
Mol. weight290.323
PubChem CID5578
InChIKeyIEDVJHCEMCRBQM-UHFFFAOYSA-N
SMILESCOC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
59,853Patents
8,376Research papers
6,274Patents - last 3 years
129Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Human Genome Sciences Inc894
2University of California San Diego UCSD498
3Massachusetts Institute of Technology464
4AbbVie Inc421
5Bristol Myers Squibb Co417
6Allergan Inc410
7BASF SE341
8Harvard University335
9Bayer AG322
10Novartis AG259

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations38,119
2A61PTherapeutic activity (drug indications)34,206
3C07KPeptides11,915
4C12NMicroorganisms, enzymes10,559
5C07DHeterocyclic compounds10,213
6Y02AClimate change adaptation8,226
7G01NInvestigating / analysing materials5,101
8A61LSterilising / disinfecting materials4,411
9C12QMeasuring/testing involving enzymes3,966
10A01NPreservation of bodies; biocides; pest repellents3,613

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Bacteriocin Bacin A4 and application thereof2022HUAIBEI NORMAL UNIVERSITY2
SEALED BACIN.2000LOURIDO FERNANDEZ LUIS0
A bacin flat of bed, or shit. (Machine-translation by Google Translate, not legally binding)1968Svenska Cellulosa AB0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Pneumocystis jirovecii pneumonia detection and treatment37
2Urinary Tract Infections Management27
3Antibiotic Resistance in Bacteria15
4Antibiotics Pharmacokinetics and Efficacy9
5Actinomycetales infections and treatment7
6Neutropenia and Cancer Infections7
7Pharmacological Effects and Toxicity Studies7
8Pneumonia and Respiratory Infections7
9Antibiotic Use and Resistance6
10Antimicrobial Resistance in Staphylococcus6

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Sherry F. QueenerIndiana University – Purdue University Indianapolis42
2Aleem GangjeeDuquesne University27
3Allan RonaldUniversity of Manitoba13
4R. N. GrünebergUniversity College London13
5Rudolf ThenRoche (Switzerland)12
6S. G. B. AmyesUniversity of London12
7J. FeeneyNational Institute for Medical Research11
8W. BrumfittUniversity College London11
9Anil VasudevanDuquesne University5
10J. M. T. Hamilton‐MillerUniversity College London10

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical structure of Acuco?

Acuco has the canonical name 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine with the molecular formula C14H18N4O3 and a molecular weight of 290.323. Its InChI Key is IEDVJHCEMCRBQM-UHFFFAOYSA-N.

What are the primary research topics associated with Acuco?

The compound is most prominently associated with Pneumocystis jirovecii pneumonia detection and treatment, followed by Urinary Tract Infections Management and Antibiotic Resistance in Bacteria. Additional research topics include Antibiotics Pharmacokinetics and Efficacy, Neutropenia and Cancer Infections, and Antimicrobial Resistance in Staphylococcus.

Which institutions and companies have published the most research on this compound?

Leading researchers include Sherry F. Queener from Indiana University – Purdue University Indianapolis with 42 papers, and Aleem Gangjee from Duquesne University with 27 papers. Among patent assignees, Human Genome Sciences Inc leads with 894 patents, followed by University of California San Diego UCSD with 498 patents.

What patent classifications dominate the intellectual property landscape for this compound?

The compound is most heavily covered under patent classification A61K (medicinal preparations) with 38,113 patents, followed by A61P (therapeutic applications) with 34,204 patents. Other significant classifications include C07K (peptide and protein chemistry) with 11,915 patents and C12N (microbiology and enzymology) with 10,558 patents.

How has research activity on this compound trended in recent years?

Patent activity peaked in 2021 with 3,224 patents, declining slightly to 2,874 in 2024. Academic papers showed peaks in 2022 with 88 papers and 2023 with 68 papers. In the last three years (2022–2024), there were 6,405 patents and 129 papers published.

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