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Zymostanol

(8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol · also: beta-Cholestanol, Dihydrocholesterol, Dihydrocholestenol, Dihydrocholesterin

FormulaC27H48O
Mol. weight388.68
PubChem CID10992748
InChIKeyQYIXCDOBOSTCEI-BPAAZKTESA-N
SMILESC[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4[C@@]3(CCC(C4)O)C)C
6,481Patents
622Research papers
1,414Patents - last 3 years
19Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Biontech SE158
2Merck Sharp & Dohme LLC111
3Kao Corp101
4Lipocine Inc91
5NOF Corp90
6Kimberly Clark Worldwide Inc86
7Lion Corp85
8Harvard University76
9Fujifilm Corp72
10Elan Pharmaceuticals LLC65

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations4,651
2A61PTherapeutic activity (drug indications)3,113
3C12NMicroorganisms, enzymes1,815
4A61QCosmetics, personal care1,039
5C07KPeptides771
6C07DHeterocyclic compounds574
7C07CAcyclic and carbocyclic compounds508
8C07J377
9G01NInvestigating / analysing materials329
10C12YEnzyme nomenclature (EC numbers)282

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Preparation method of dihydrocholesterol and cholestanone2009ANHUI CHEN-BRIGHT BIOENGINEERING CO., LTD.3
Method for preparing dihydrocholesterol and cholestanone2011ANHUI CHEN-BRIGHT BIOENGINEERING CO., LTD.1
USE OF DIHYDROCHOLESTEROL2017Nestec SA0
USE OF DIHYDROCHOLESTEROL2016Nestec SA0
Method for preparing dihydrocholesterol and cholestanone2013ANHUI CHEN-BRIGHT BIOENGINEERING CO., LTD.0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Cholesterol and Lipid Metabolism9
2Lipoproteins and Cardiovascular Health2
3Analytical Chemistry and Chromatography1
4Diet, Metabolism, and Disease1
5Drug Transport and Resistance Mechanisms1
6Groundwater and Isotope Geochemistry1
7Helicobacter pylori-related gastroenterology studies1
8Microbial infections and disease research1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Helena GyllingUniversity of Eastern Finland18
2Antonio FedericoUniversity of Siena12
3Ingemar BjörkhemKarolinska Institutet12
4Tatu A. MiettinenUniversity of Helsinki9
5Gerald SalenUnited States Department of Veterans Affairs9
6Aad VerripsCanisius-Wilhelmina Ziekenhuis8
7Dieter LütjohannUniversity Hospital Bonn8
8Andrea E. DeBarberOregon Health & Science University7
9Andrea MignarriUniversity of Siena6
10Elisabeth NorinKarolinska Institutet6

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Zymostanol?

Zymostanol has the molecular formula C27H48O with a molecular weight of 388.68 g/mol. It is also known by several synonyms including beta-Cholestanol, Dihydrocholesterol, Dihydrocholestenol, and Dihydrocholesterin.

Which companies hold the most patents related to Zymostanol?

The leading patent holders in the Zymostanol space are Biontech SE with 158 patents, followed by Merck Sharp and Dohme LLC with 111 patents, and Kao Corp with 101 patents. Other significant assignees include Lipocine Inc and NOF Corp, each with 91 patents.

What research has been published on Zymostanol and cholesterol metabolism?

Research on Zymostanol spans multiple areas, with significant work in Cholesterol and Lipid Metabolism. A notable 1998 paper titled 'Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study' has been highly cited with 257 citations and addresses Lipoproteins and Cardiovascular Health. More recent work includes a 2020 paper on 'Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level' with 308 citations.

Who are the most prolific researchers publishing on Zymostanol?

Helena Gylling from the University of Eastern Finland is the most prolific author with 16 papers on the topic. Other leading researchers include Antonio Federico and Ingemar Björkhem, each with 12 papers, affiliated with the University of Siena and Karolinska Institutet respectively. Tatu A. Miettinen and Gerald Salen have each published 9 papers on related topics.

What is the patent trend for Zymostanol-related inventions in recent years?

Patent activity related to Zymostanol has grown significantly in recent years. From 2016 to 2024, annual patent filings increased from 155 to 626, with particularly strong growth in 2022–2024 (440, 568, and 626 patents respectively). The most common patent classification is A61K (pharmaceutical preparations) with 4,651 patents, followed by A61P (therapeutic applications) with 3,112 patents.

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