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Zatosetron maleate

(Z)-but-2-enedioic acid;5-chloro-2,2-dimethyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-3H-1-benzofuran-7-carboxamide · also: Zatosetronmaleat · LY277359 maleate · LY-277359 maleate · LY 277359 maleate · Zatosetron (maleate) · Zatosetron maleate (USAN)

FormulaC23H29ClN2O6
Mol. weight464.943
PubChem CID6918153
InChIKeyHAFQATMFFHYNPN-BSLJCGBVSA-N
SMILESCC1(CC2=C(O1)C(=CC(=C2)Cl)C(=O)NC3C[C@H]4CC[C@@H](C3)N4C)C.C(=C\C(=O)O)\C(=O)O
139Patents
22Research papers
11Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Aquestive Therapeutics Inc24
2The University of Texas System19
3University of Alabama System11
4Celanese Corp9
5Daiichi Sankyo Co Ltd8
6Eli Lilly and Co6
7Ascendis Pharma AS5
8Scripps Research Institute5
9Novartis AG4
10Tolmar Holding Inc4

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations120
2A61PTherapeutic activity (drug indications)76
3A61MDevices for introducing media into the body27
4C07DHeterocyclic compounds17
5Y02AClimate change adaptation16
6Y10TCross-reference (technical subjects)15
7A01NPreservation of bodies; biocides; pest repellents14
8C08LPolymer compositions (blends)14
9B81B11
10B81C11

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
METHODS AND COMPOSITIONS OF BIOLOGICALLY ACTIVE AGENTS2017Wave Life Sciences Pte Ltd149
DHA-pharmaceutical agent conjugates of taxanes1998Daiichi Sankyo Co Ltd360
DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS2011Ascendis Pharma AS179
Modified release composition for highly soluble drugs2012Torrent Pharmaceuticals Ltd164
Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients2012Torrent Pharmaceuticals Ltd160

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Marlene L. CohenEli Lilly (United States)4
2J. S. GiddaEli Lilly (United States)3
3Rex Y. WangStony Brook University2
4Barbara J. RingEli Lilly (United States)2
5Yoshio MinabeStony Brook University2
6C. John ParliEli Lilly (United States)2
7David W. RobertsonEli Lilly (United States)2
8Charles R. AshbyStony Brook University2
9Steven WrightonEli Lilly (United States)2
10William B. LacefieldEli Lilly (United States)2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of zatosetron maleate?

Zatosetron maleate has the molecular formula C23H29ClN2O6 and a molecular weight of 464.943 g/mol.

Which organizations hold the most patents related to zatosetron maleate?

Aquestive Therapeutics Inc holds the most patents with 24, followed by The University of Texas System with 19 patents and University of Alabama System with 11 patents.

What research topics are covered by the published papers on zatosetron maleate?

Published papers cover topics including pharmacogenetics and drug metabolism, pain mechanisms and treatments, gastrointestinal motility and disorders, and schizophrenia research and treatment.

What are the primary patent classification codes for zatosetron maleate inventions?

The dominant patent classifications are A61K (pharmaceutical preparations) with 120 patents, A61P (specific therapeutic activity of chemical compounds) with 76 patents, and A61M (devices for introducing media into the body) with 27 patents.

How has patent activity for zatosetron maleate changed over recent years?

Patent activity peaked in 2022 with 12 patents, following a significant increase from 2021 with 11 patents. More recent years show lower counts, with 9 patents in 2023, 3 in 2024, and 4 in 2025. The total patent portfolio contains 139 patents across all years.

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