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Zatosetronmaleat

(Z)-but-2-enedioic acid;5-chloro-2,2-dimethyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-3H-1-benzofuran-7-carboxamide

FormulaC23H29ClN2O6
Mol. weight464.943
PubChem CID6918153
InChIKeyHAFQATMFFHYNPN-BSLJCGBVSA-N
SMILESCC1(CC2=C(O1)C(=CC(=C2)Cl)C(=O)NC3C[C@H]4CC[C@@H](C3)N4C)C.C(=C\C(=O)O)\C(=O)O
139Patents
22Research papers
12Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Aquestive Therapeutics Inc24
2The University of Texas System19
3University of Alabama at Birmingham UAB10
4University of Texas at Austin9
5American Regent Inc8
6Eli Lilly and Co6
7Ascendis Pharma AS5
8Scripps Research Institute5
9University of Alabama5
10Celanese EVA Performance Polymers Inc4

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations120
2A61PTherapeutic activity (drug indications)76
3A61MDevices for introducing media into the body27
4C07DHeterocyclic compounds17
5Y02AClimate change adaptation16
6Y10TCross-reference (technical subjects)15
7A01NPreservation of bodies; biocides; pest repellents14
8C08LPolymer compositions (blends)14
9B81B11
10B81C11

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Cancer Treatment and Pharmacology1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Charles R. AshbyStony Brook University2
2Marlene L. CohenEli Lilly (United States)4
3J. S. GiddaEli Lilly (United States)3
4Rex Y. WangStony Brook University2
5A.M. BendeleEli Lilly (United States)2
6Barbara J. RingEli Lilly (United States)2
7C. John ParliEli Lilly (United States)2
8David W. RobertsonEli Lilly (United States)2
9Steven WrightonEli Lilly (United States)2
10William B. LacefieldEli Lilly (United States)2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Zatosetronmaleat?

Zatosetronmaleat has the molecular formula C23H29ClN2O6 and a molecular weight of 464.943. Its canonical name is (Z)-but-2-enedioic acid;5-chloro-2,2-dimethyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-3H-1-benzofuran-7-carboxamide, with an InChI Key of HAFQATMFFHYNPN-BSLJCGBVSA-N.

Which organizations hold the most patents related to Zatosetronmaleat?

Aquestive Therapeutics Inc holds the largest patent portfolio with 24 patents, followed by University of Texas System with 19 patents and University of Alabama at Birmingham UAB with 10 patents. Other significant patent holders include University of Texas at Austin, American Regent Inc, and Eli Lilly and Co.

What intellectual property activity has been observed for Zatosetronmaleat in recent years?

The compound has a total patent count of 139 across all years. In the last 3 years, there have been 13 patents filed. Patent activity peaked in 2021 and 2022 with 11 and 12 patents respectively, declining to 3 patents in 2024 and 4 in 2025.

What are the main patent classification areas for Zatosetronmaleat?

The primary patent classifications are A61K (120 patents) covering pharmaceutical preparations, followed by A61P (76 patents) for specific therapeutic uses, and A61M (27 patents) for medical devices. Chemical composition patents are classified under C07D (17 patents).

What research themes appear in the scientific literature on Zatosetronmaleat?

Published research includes studies on drug metabolism and cytochromes P450, serotonergic modulation, 5-HT3 receptor antagonism, and emesis prevention. Notably, one 1994 paper examined the in vitro metabolism of zatosetron and the role of CYP 3A in interspecies comparison. Authors from Eli Lilly and Stony Brook University have contributed significantly to this literature.

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