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Bromfenac sodium hydrate

sodium;2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate;hydrate · also: XiDay · Duract · Xibrom · Remura · Bronuck · Xibrom QD

FormulaC15H13BrNNaO4
Mol. weight374.1658
PubChem CID23663409
InChIKeyBIYQNLJPABKADF-UHFFFAOYSA-M
SMILESC1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)[O-].O.[Na+]
1,272Patents
186Research papers187 indexed in detail
173Patents - last 3 years
10Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Gilead Sciences Inc109
2Clearside Biomedical Inc67
3Senju Pharmaceutical Co Ltd58
4Institució Catalana de Recerca i Estudis Avançats43
5University of Virginia37
6Roche Holding AG26
7Rohto Pharmaceutical Co Ltd23
8Alcon Inc21
9Ascendis Pharma AS21
10Kala Bio Inc20

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations969
2A61PTherapeutic activity (drug indications)890
3C07KPeptides244
4C07DHeterocyclic compounds218
5G01NInvestigating / analysing materials162
6C12QMeasuring/testing involving enzymes125
7A61MDevices for introducing media into the body94
8A61F85
9C07CAcyclic and carbocyclic compounds85
10C12NMicroorganisms, enzymes62

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Gel for eye containing bromfenac sodium hydrate and preparation thereof20086
Bromfenac sodium hydrate eye drops and preparation method thereof20134
A kind of pharmaceutical aqueous eye drops and preparation method thereof containing bromfenac sodium hydrate20183
A kind of bromfenac sodium hydrate thermosensitive type situ-gel eye drop and preparation method thereof20163
Gel for eye containing bromfenac sodium hydrate and preparation thereof20130

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20168
20176
20189
20198
20207
20215
20229
20233
20247

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1James A. GowSpectrum Pharmaceuticals (United States)7
2Sheryl DeCleeneWomen's Health Research Institute6
3L. David WaterburyEmergent BioSolutions (Canada)6
4Frank A. BucciBucci Laser Vision Institute5
5Joan Korth‐BradleyWomen's Health Research Institute5
6William H. CevallosWomen's Health Research Institute4
7Timothy R. McNamaraSpectrum Pharmaceuticals (United States)4
8Joseph BoniWomen's Health Research Institute3
9Najam A. SharifAlcon (United States)3
10Hiroshi FujishimaTsurumi University3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Bromfenac sodium hydrate?

Bromfenac sodium hydrate has the molecular formula C15H13BrNNaO4 and a molecular weight of 374.1658 g/mol. Its canonical name is sodium;2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate;hydrate.

Which organizations hold the most patents for Bromfenac sodium hydrate?

Gilead Sciences Inc leads with 109 patents, followed by Clearside Biomedical Inc with 67 patents and Senju Pharmaceutical Co Ltd with 58 patents. Other significant patent holders include Institució Catalana de Recerca i Estudis Avançats with 43 patents and University of Virginia with 37 patents.

What is the trend in patent activity for Bromfenac sodium hydrate over recent years?

Patent activity has shown fluctuation, with peaks in 2022 (98 patents) and 2024 (87 patents). The year 2017 saw 81 patents, 2021 saw 85 patents, and 2023 saw 77 patents. In the last three years (2023-2025), 173 patents have been filed in total.

What formulation types of Bromfenac sodium hydrate have been patented?

Multiple formulation types have been patented, including gel eye formulations, eye drops, thermosensitive in-situ gel eye drops, and pharmaceutical aqueous eye drops. Specific patents describe a gel for eye containing bromfenac sodium hydrate, bromfenac sodium hydrate eye drops, and thermosensitive type in-situ-gel eye drop preparations.

What research topics are associated with published papers on Bromfenac sodium hydrate?

Published research covers multiple areas including comparisons of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects, retinal diseases and treatments (such as cystoid macular edema prevention after cataract surgery), drug metabolism and pharmacogenetics, and computational drug discovery methods. A total of 186-187 papers on this compound have been identified.

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