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Histrelin

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-3-(1-benzylimidazol-4-yl)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide · also: Vantaas · Histreline · Histrelina · Vantas (TN) · Histrelinum · ((ImBl)-D-His(sub 6),Pro(sub 9)-NEt)LHRH

FormulaC66H86N18O12
Mol. weight1323.528
PubChem CID25077993
InChIKeyHHXHVIJIIXKSOE-QILQGKCVSA-N
SMILESCCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
15,527Patents
93Research papers92 indexed in detail
1,894Patents - last 3 years
3Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Bayer AG1,868
2Merck and Co Inc808
3AbbVie Inc681
4Merck KGaA620
5Vertex Pharmaceuticals Inc370
6Incyte Corp289
7Roche Holding AG276
8Samsung Biologics Co Ltd248
9Organon and Co226
10Arvinas Inc219

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)12,816
2A61KMedicinal preparations12,357
3C07DHeterocyclic compounds7,954
4C07KPeptides2,926
5C12NMicroorganisms, enzymes1,142
6G01NInvestigating / analysing materials992
7Y02AClimate change adaptation774
8C07CAcyclic and carbocyclic compounds701
9C07BGeneral methods of organic chemistry623
10C12QMeasuring/testing involving enzymes544

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
IMPLANTABLE DEVICE FOR THE DELIVERY OF HISTRELIN AND METHODS OF USE THEREOF2010Endo International PLC9
Histrelin synthesizing method20133
Method for synthesizing histrelin in full liquid phase20211
Method for specifically synthesizing histrelin20171
IMPLANTABLE DEVICE FOR THE DELIVERY OF HISTRELIN AND METHODS OF USE THEREOF2010Endo International PLC0

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20161
20183
20194
20201
20212
20233

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Amicur FarkasShaare Zedek Medical Center8
2Boris ChertinShaare Zedek Medical Center8
3K. SundaramPopulation Council7
4Erica A. EugsterIndiana University – Purdue University Indianapolis7
5Irving M. SpitzBen-Gurion University of the Negev7
6David R. MeldrumUniversity of California, Los Angeles6
7Marcelle I. CedarsUniversity of California, Los Angeles6
8John K.H. LuUniversity of California, Los Angeles6
9Howard L. JuddUniversity of California, Los Angeles5
10J.L. McGuireOrtho Clinical Diagnostics (United States)4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of histrelin?

Histrelin has the molecular formula C66H86N18O12 and a molecular weight of 1323.528 g/mol.

Which companies hold the most patents related to histrelin?

The leading patent assignees for histrelin-related inventions are Bayer AG with 1868 patents, Merck and Co Inc with 808 patents, and AbbVie Inc with 681 patents.

What is the patent coverage for histrelin technology?

The histrelin technology landscape includes 15,527 total patents, with 1,894 patents filed in the last 3 years. Additionally, 93 papers were identified through database joins and 92 through text matching.

Which researchers have published the most papers on histrelin?

The most prolific authors include Amicur Farkas and Boris Chertin, both affiliated with Shaare Zedek Medical Center, each with 8 papers. K. Sundaram from Population Council, Erica A. Eugster from Indiana University – Purdue University Indianapolis, and Irving M. Spitz from Ben-Gurion University of the Negev each have 7 papers.

What are the main research topics associated with histrelin in the literature?

Key research topics include treatment of severe premenstrual syndrome, endometriosis research and treatment, reproductive biology and fertility, and clinical applications in polycystic ovarian disease. Notable papers address the role of gonadotropin-releasing hormone agonist treatments in various reproductive and hormonal conditions.

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