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Tetrahydromethanopterin

(2S)-2-[[(2R,3S,4R,5S)-5-[(2R,3S,4S)-5-[4-[[(1R)-1-[(6S,7S)-2-amino-7-methyl-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl]ethyl]amino]phenyl]-2,3,4-trihydroxypentoxy]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxypentanedioic acid · also: 5,6,7,8-Tetrahydromethanopterin · 1-(4-((1R)-1-((6S,7S)-2-amino-7-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)ethylamino)phenyl)-1-deoxy-5-O-(5-O-((1S)-1,3-dicarboxypropylphosphono)-alpha-D-ribofuranosyl)-D-ribitol

FormulaC30H45N6O16P
Mol. weight776.6898
PubChem CID135398665
InChIKeySCBIBGUJSMHIAI-LHIIQLEZSA-N
SMILESC[C@H]1[C@@H](NC2=C(N1)N=C(NC2=O)N)[C@@H](C)NC3=CC=C(C=C3)C[C@@H]([C@@H]([C@@H](CO[C@@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(O)O[C@@H](CCC(=O)O)C(=O)O)O)O)O)O)O
143Patents
35Research papers
16Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Ascendis Pharma AS16
2Henkel AG and Co KGaA5
3Colorado State University System4
4Harvard University4
5Corteva Inc3
6Ginkgo Bioworks Holdings Inc3
7MerLion Pharmaceuticals GmbH3
8University of Minnesota System3
9BASF SE2
10Eli Lilly and Co2

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes77
2A61KMedicinal preparations50
3C12PFermentation, enzyme processes47
4C07KPeptides42
5Y02EClimate change mitigation: energy42
6C12YEnzyme nomenclature (EC numbers)33
7Y02PClimate change mitigation: production18
8A61PTherapeutic activity (drug indications)17
9G01NInvestigating / analysing materials17
10C07CAcyclic and carbocyclic compounds14

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS2011Ascendis Pharma AS176
HYDROGEL PRODRUGS2014Ascendis Pharma AS64
Probiotic and prebiotic compositions, and methods of use thereof for treatment and prevention of graft versus host disease201742
Selected polynucleotide and polypeptide sequences of the methanogenic archaeon, methanococcus jannashii2003J Craig Venter Institute Inc52
Compositions, apparatus, systems, and methods for resolving electronic excited states201518

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20161
20191

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Mary E. LidstromUniversity of Washington8
2Julia A. VorholtMax Planck Institute for Terrestrial Microbiology7
3Rudolf K. ThauerMax Planck Institute for Terrestrial Microbiology6
4Ludmila ChistoserdovaUniversity of Washington6
5Christopher J. MarxUniversity of Washington5
6R. S. WolfeUniversity of Illinois Urbana-Champaign4
7Ulrich ErmlerMax Planck Institute of Biophysics3
8Marina KalyuzhnayaUniversity of Washington3
9Seigo ShimaMax Planck Institute for Terrestrial Microbiology2
10Olivier NercessianUniversity of Washington2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and molecular weight of tetrahydromethanopterin?

Tetrahydromethanopterin has the molecular formula C30H45N6O16P and a molecular weight of 776.6898 g/mol.

Which organizations hold the most patents related to tetrahydromethanopterin?

Ascendis Pharma AS holds the most patents with 16 patent filings, followed by Henkel AG and Co KGaA with 5 patents, and Colorado State University System and Harvard University each with 4 patents.

What are the primary research areas covered by patents related to this compound?

The primary patent classification areas are C12N (Microorganisms or enzymes) with 77 patents, A61K (Preparations for medical purposes) with 50 patents, and C12P (Fermentation processes) with 47 patents, indicating focus on biotechnology, pharmaceutical, and bioprocessing applications.

Who are the leading academic researchers publishing on tetrahydromethanopterin?

Mary E. Lidstrom from University of Washington has published 8 papers on this topic, followed by Julia A. Vorholt from Max Planck Institute for Terrestrial Microbiology with 7 papers, and Rudolf K. Thauer also from Max Planck Institute for Terrestrial Microbiology with 6 papers.

How has patent activity around tetrahydromethanopterin changed over recent years?

Patent activity shows fluctuation over the past decade, with notable years being 2024 with 10 patents and 2016 with 9 patents. In the last three years (2022-2024), there were 21 total patents filed. Academic publications on this compound were minimal in recent years, with the last recorded papers from 2019 and earlier.

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