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TBE buffer

2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;boric acid · also: tris-borate EDTA · 2-Amino-2-(hydroxymethyl)propane-1,3-diol 2,2',2'',2'''-(ethane-1,2-diylbis(azanetriyl))tetraacetate borate

FormulaC14H30BN3O14
Mol. weight475.211
PubChem CID21257725
InChIKeyOSBLTNPMIGYQGY-UHFFFAOYSA-N
SMILESB(O)(O)O.C(CN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O.C(C(CO)(CO)N)O
16,921Patents
22Research papers
2,131Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Bayer AG2,187
2Novo Nordisk Fonden552
3Bristol Myers Squibb Co367
4Roche Holding AG236
5Alnylam Pharmaceuticals Inc197
6Corteva Inc171
7The University of Texas System157
8Novartis AG150
9Thermo Fisher Scientific Inc140
10Centre National de la Recherche Scientifique120

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes7,133
2C12QMeasuring/testing involving enzymes4,616
3A61KMedicinal preparations4,508
4C07KPeptides4,445
5A61PTherapeutic activity (drug indications)4,169
6A01H2,284
7G01NInvestigating / analysing materials2,272
8C12PFermentation, enzyme processes1,247
9C12YEnzyme nomenclature (EC numbers)1,159
10Y02AClimate change adaptation1,087

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION2013University of California1,674
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme1990Roche Holding AG3,800
Peptide nucleic acids19961,983
Strand displacement amplification1995Becton Dickinson and Co1,427
Modifying plants by genetic engineering to combat or control insects1991Bayer AG1,490

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20191

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Nancy C. StellwagenUniversity of Iowa3
2László OrbánAgricultural Biotechnology Institute2
3Attila ZsolnaiVeszprémi Érseki Hittudományi Fõiskola2
4Jacek SzeligaNicolaus Copernicus University1
5Benjamin ChuStony Brook University1
6JO NORTHROPUniversity of Tennessee at Knoxville1
7N.M. PettitUniversity of Tennessee at Knoxville1
8Mary K. CowmanNew York University1
9Dehai LiangStony Brook University1
10Daniele GerionLawrence Livermore National Laboratory1

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of TBE buffer?

TBE buffer has the molecular formula C14H30BN3O14 and a molecular weight of 475.211. It is a combination of three components: 2-amino-2-(hydroxymethyl)propane-1,3-diol, 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid, and boric acid.

How many patents mention TBE buffer and what is the recent patent activity trend?

There are 16,921 total patents mentioning TBE buffer, with 2,131 patents filed in the last three years. Patent activity has grown significantly, with 1,111 patents in 2024 and 904 in 2023, compared to 451 in 2016.

Which companies hold the most patents related to TBE buffer applications?

The leading patent assignees for TBE buffer-related inventions are Bayer AG with 2,187 patents, Novo Nordisk Fonden with 552 patents, and Bristol Myers Squibb Co with 367 patents.

What are the primary technical fields where TBE buffer patents are classified?

TBE buffer patents are predominantly classified in biotechnology and diagnostic fields: C12N (7,133 patents in nucleotide/protein chemistry), C12Q (4,616 patents in biochemical analysis/testing), A61K (4,508 patents in pharmaceutical preparations), and C07K (4,445 patents in organic compounds). These reflect its use in molecular biology and diagnostic applications.

Who are the leading research authors publishing on TBE buffer?

Nancy C. Stellwagen from University of Iowa is the most prolific author, with 3 papers on TBE buffer. László Orbán from Agricultural Biotechnology Institute and Attila Zsolnai from Veszprémi Érseki Hittudományi Fõiskola each have 2 papers.

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