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TBE buffer

2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;boric acid · also: tris-borate EDTA, tris-borate-edta, Tris-Borate-EDTA buffer, Tris-Borate-EDTA Buffer for Electrophoresis

FormulaC14H30BN3O14
Mol. weight475.211
PubChem CID21257725
InChIKeyOSBLTNPMIGYQGY-UHFFFAOYSA-N
SMILESB(O)(O)O.C(CN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O.C(C(CO)(CO)N)O
16,921Patents
22Research papers
2,269Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Monsanto Technology LLC2,132
2Zymogenetics Inc273
3Novozymes Inc239
4Novozymes AS232
5Sirna Therapeutics Inc121
6Centre National de la Recherche Scientifique117
7Genentech Inc113
8The University of Texas System108
9Novartis AG103
10EIDP Inc91

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes7,133
2C12QMeasuring/testing involving enzymes4,614
3A61KMedicinal preparations4,504
4C07KPeptides4,444
5A61PTherapeutic activity (drug indications)4,167
6A01H2,284
7G01NInvestigating / analysing materials2,270
8C12PFermentation, enzyme processes1,247
9C12YEnzyme nomenclature (EC numbers)1,154
10Y02AClimate change adaptation1,087

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Microfluidic and Capillary Electrophoresis Applications1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Nancy C. StellwagenUniversity of Iowa3
2Attila ZsolnaiVeszprémi Érseki Hittudományi Fõiskola2
3Jun WangNational Institutes of Natural Sciences2
4László OrbánAgricultural Biotechnology Institute2
5Abraham WolcottLawrence Livermore National Laboratory1
6Adam SchwartzbergLawrence Livermore National Laboratory1
7Adrian R. Krainer1
8Akila MayedaCold Spring Harbor Laboratory1
9Alan D. FrankelUniversity of California, San Francisco1
10Alicia R. TiptonUniversity of California, San Francisco1

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition of TBE buffer?

TBE buffer is composed of three main components: 2-amino-2-(hydroxymethyl)propane-1,3-diol, 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid, and boric acid, with a combined molecular formula of C14H30BN3O14 and a molecular weight of 475.211.

What are the alternative names for TBE buffer?

TBE buffer is known by several synonyms including tris-borate EDTA, tris-borate-edta, Tris-Borate-EDTA buffer, and Tris-Borate-EDTA Buffer for Electrophoresis.

Which organizations hold the most patents related to TBE buffer?

Monsanto Technology LLC leads with 2,132 patents, followed by Zymogenetics Inc with 273 patents and Novozymes Inc with 239 patents in the TBE buffer patent landscape.

What research areas are most associated with TBE buffer patents?

The largest patent classification areas for TBE buffer-related inventions are biotechnology and microbiology (C12N with 7,131 patents), molecular biology assays (C12Q with 4,614 patents), and pharmaceutical/medicinal chemistry (A61K with 4,504 patents).

How has patent activity for TBE buffer evolved in recent years?

Patent activity has grown significantly, with 2,313 patents filed in the last three years. Annual filings increased from 451 in 2016 to peaks of 1,111 in 2024 and 978 in 2023, demonstrating sustained research interest in TBE buffer applications.

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