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tacalciol

(1S)-3-[(E)-2-[(1R,3aR,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-4-methylcyclohex-3-en-1-ol · also: Cholecalciferol Impurity E, Cholecalciferol EP Impurity E

FormulaC27H44O
Mol. weight384.648
PubChem CID5283713
InChIKeyYUGCAAVRZWBXEQ-FMCTZRJNSA-N
SMILESCC1=C(C[C@H](CC1)O)/C=C/C2=CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CCCC(C)C)C
113Patents
55Research papers
3Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Ono Pharmaceutical Co Ltd17
2Duphar International Research BV14
3Abbott Products Operations AG3
4Boston University3
5University of California San Diego UCSD3
6Vyne Therapeutics Inc3
7Bayer Pharma AG2
8F Hoffmann La Roche AG2
9Journey Medical Corp2
10Koninklijke Philips NV2

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations67
2A61PTherapeutic activity (drug indications)53
3C07DHeterocyclic compounds33
4C07CAcyclic and carbocyclic compounds28
5C07BGeneral methods of organic chemistry21
6A61QCosmetics, personal care15
7C07J10
8C07KPeptides8
9A23LFoods and beverages (general)6
10C08FPolymers from C=C unsaturated bonds6

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Vitamin D Research Studies3

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Michael F. HolickBoston University19
2Atsushi KittakaTeikyo University5
3Daisuke SawadaTeikyo University5
4Tai C. ChenBoston University5
5Xiao Quan TianBoston Medical Center5
6Hiroshi SaitoTeijin (Japan)4
7Kazuya TakenouchiTeijin (Japan)4
8Yuya TsukudaTeikyo University4
9Eiji OchiaiTeijin (Japan)3
10Eva M. CodesidoUniversidade de Santiago de Compostela3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is tacalciol and what is its chemical composition?

Tacalciol is a compound with the molecular formula C27H44O and a molecular weight of 384.648. It is also known as Cholecalciferol Impurity E or Cholecalciferol EP Impurity E. Its canonical chemical name is (1S)-3-[(E)-2-[(1R,3aR,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-4-methylcyclohex-3-en-1-ol.

Which organizations hold the most patents related to tacalciol?

Ono Pharmaceutical Co Ltd holds the most patents related to tacalciol with 17 patents, followed by Duphar International Research BV with 14 patents. Abbott Products Operations AG, Boston University, and University of California San Diego UCSD each hold 3 patents related to the compound.

What research topics are associated with tacalciol literature?

Tacalciol is associated with research on Vitamin D Research Studies, which accounts for 3 papers in the covered literature. The broader patent classification shows that work on this compound spans pharmaceutical preparations (A61K with 67 patents), pharmaceutical therapeutic uses (A61P with 53 patents), and organic chemistry synthesis methods (C07D with 33 patents and C07C with 28 patents).

Who are the leading researchers publishing on tacalciol?

Michael F. Holick from Boston University is the most prolific author in the tacalciol literature with 19 papers. Other significant contributors include Atsushi Kittaka, Daisuke Sawada, and Yuya Tsukuda from Teikyo University, each with multiple publications on the compound.

What is the current research activity level for tacalciol?

The compound has moderate ongoing research activity. Over the last 3 years, there have been 3 patents filed related to tacalciol, with 2024 and 2025 each showing at least 1 patent filing. However, there have been no papers published in the last 3 years, with the most recent literature dating to 2022. In total, the compound is covered by 113 patents and 55 papers in the available databases.

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