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t-Butyinitrite

tert-butyl nitrite · also: t-butylnitrite, t-Butyl nitrite, t-butyl-nitrite, tert-butylnitrit, tertbutyl nitrite, tert-butylnitrite

FormulaC4H9NO2
Mol. weight103.121
PubChem CID10906
InChIKeyIOGXOCVLYRDXLW-UHFFFAOYSA-N
SMILESCC(C)(C)ON=O
24,569Patents
22Research papers
3,629Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck Sharp & Dohme LLC832
2F Hoffmann La Roche AG810
3Bristol Myers Squibb Co511
4BASF SE352
5Novartis AG345
6Bayer AG313
7Janssen Pharmaceutica NV223
8Organon Pharma UK Ltd199
9AstraZeneca AB191
10FMC Corp185

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C07DHeterocyclic compounds20,630
2A61PTherapeutic activity (drug indications)17,081
3A61KMedicinal preparations11,676
4C07CAcyclic and carbocyclic compounds3,507
5A01NPreservation of bodies; biocides; pest repellents3,064
6C07FOrganometallic compounds1,882
7C07BGeneral methods of organic chemistry1,249
8C07KPeptides953
9Y02PClimate change mitigation: production704
10H10KOrganic semiconductors / OLEDs666

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Matthias BellerUniversity of Rostock2
2Richard A. J. O’HairThe University of Melbourne2
3Ryan Patrick McLaughlinSeattle University2
4Satoshi SakaguchiKansai University2
5Victor RyzhovNorthern Illinois University2
6Yasutaka IshiiKansai University2
7A. RosowskyHarvard University1
8Adam D. MoorhouseUniversity of London1
9Adrian K. Y. LamThe University of Melbourne1
10Alan C. SartorelliYale University1

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of tert-butyl nitrite?

tert-butyl nitrite has the molecular formula C4H9NO2 and a molecular weight of 103.121. It is also known by several synonyms including t-butyl nitrite, tert-butyl-nitrite, and Nitrous acid tert-butyl ester.

Which pharmaceutical companies have the most patents involving this compound?

The leading patent holders are Merck Sharp and Dohme LLC with 832 patents, F Hoffmann La Roche AG with 810 patents, and Bristol Myers Squibb Co with 511 patents. Other significant assignees include BASF SE, Novartis AG, and Bayer AG.

What are the primary research areas involving tert-butyl nitrite based on published papers?

Key research topics include Chemical Synthesis and Analysis, Catalytic Cross-Coupling Reactions, and Catalytic C–H Functionalization Methods. Notable applications include efficient conversion of aromatic amines into azides, chemoselective nitration of phenols, and iron-catalyzed synthesis of oximes from styrenes.

What technology classifications dominate the patent landscape for this compound?

The dominant CPC subclasses are C07D (heterocyclic compounds) with 20,626 patents, A61P (pharmaceutical activity classification) with 17,079 patents, and A61K (preparations for medical purposes) with 11,657 patents. This reflects significant use in pharmaceutical and chemical synthesis applications.

How has patent activity for this compound trended in recent years?

Patent filing activity has shown substantial growth, increasing from 787 patents in 2016 to a peak of 1,687 patents in 2024. The last three years (2022-2024) accounted for 4,820 patents out of 3,710 total patents in the last three years, demonstrating sustained and growing interest in this compound.

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