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Tert-Butyl nitrite

tert-butyl nitrite · also: t-Butyinitrite, t-butylnitrite, t-butyl-nitrite, t-Butyl nitrite, tert-butylnitrit, tert-butylnitrite

FormulaC4H9NO2
Mol. weight103.121
PubChem CID10906
InChIKeyIOGXOCVLYRDXLW-UHFFFAOYSA-N
SMILESCC(C)(C)ON=O
24,569Patents
22Research papers
3,510Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck Sharp & Dohme LLC832
2F Hoffmann La Roche AG810
3Bristol Myers Squibb Co511
4BASF SE352
5Novartis AG345
6Bayer AG313
7Janssen Pharmaceutica NV223
8Organon Pharma UK Ltd199
9AstraZeneca AB188
10FMC Corp185

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C07DHeterocyclic compounds20,631
2A61PTherapeutic activity (drug indications)17,082
3A61KMedicinal preparations11,685
4C07CAcyclic and carbocyclic compounds3,508
5A01NPreservation of bodies; biocides; pest repellents3,064
6C07FOrganometallic compounds1,883
7C07BGeneral methods of organic chemistry1,254
8C07KPeptides953
9Y02PClimate change mitigation: production704
10H10KOrganic semiconductors / OLEDs666

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
TERT-BUTYL NITRITE PHARMACEUTICAL COMPOSITION FOR INJECTION, AND PREPARATION METHOD THEREOF2023GUANGZHOU MAGPIE PHARMACEUTICALS Co.,Ltd.0
Application of copper catalyst in catalyzing reaction of 1-pyridyl indole compound and tert-butyl nitrite2021SOOCHOW UNIVERSITY0
Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite2020SUZHOU UNIVERSITY0
Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite2020SOOCHOW UNIVERSITY0
TERT-BUTYL NITRIT AS VASODILATOR AND USE THEREOF1993LARS E GUSTAFSSON0

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Matthias BellerUniversity of Rostock2
2Richard A. J. O’HairThe University of Melbourne2
3Ryan Patrick McLaughlinSeattle University2
4Satoshi SakaguchiKansai University2
5Victor RyzhovNorthern Illinois University2
6Yasutaka IshiiKansai University2
7A. RosowskyHarvard University1
8Adam D. MoorhouseUniversity of London1
9Adrian K. Y. LamThe University of Melbourne1
10Alan C. SartorelliYale University1

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of tert-butyl nitrite?

Tert-butyl nitrite has the molecular formula C4H9NO2 and a molecular weight of 103.121 g/mol.

Which pharmaceutical and chemical companies hold the most patents involving tert-butyl nitrite?

The assignees with the highest patent counts are Merck Sharp & Dohme LLC with 832 patents, F Hoffmann La Roche AG with 810 patents, and Bristol Myers Squibb Co with 511 patents.

What are the primary research topics associated with tert-butyl nitrite in academic literature?

Published research on tert-butyl nitrite covers Chemical Synthesis and Analysis, including chemoselective nitration of phenols and efficient conversion of aromatic amines into azides, as well as Catalytic Cross-Coupling Reactions and Catalytic C–H Functionalization Methods.

What is the trend in patent activity for tert-butyl nitrite in recent years?

Patent activity involving tert-butyl nitrite has shown significant growth, rising from 787 patents in 2016 to 1,687 patents in 2024. In the last three years, there were 3,510 patents filed.

Which chemical and pharmaceutical classification codes are most associated with tert-butyl nitrite patents?

The most prevalent CPC subclasses are C07D (heterocyclic compounds) with 20,631 patents, A61P (therapeutic applications) with 17,082 patents, and A61K (pharmaceutical preparations) with 11,685 patents.

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