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Tert-Butyl nitrite

tert-butyl nitrite · also: t-Butyinitrite · t-butylnitrite · t-butyl-nitrite · t-Butyl nitrite · tert-butylnitrit · ter-butyl nitrite

FormulaC4H9NO2
Mol. weight103.121
PubChem CID10906
InChIKeyIOGXOCVLYRDXLW-UHFFFAOYSA-N
SMILESCC(C)(C)ON=O
24,569Patents
22Research papers
3,362Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck and Co Inc1,128
2Roche Holding AG1,001
3Bayer AG786
4Bristol Myers Squibb Co519
5Sinochem Holdings Corp Ltd453
6BASF SE374
7Novartis AG367
8C.H. Boehringer Sohn AG and Co KG298
9AstraZeneca PLC276
10Johnson and Johnson260

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C07DHeterocyclic compounds20,631
2A61PTherapeutic activity (drug indications)17,082
3A61KMedicinal preparations11,712
4C07CAcyclic and carbocyclic compounds3,508
5A01NPreservation of bodies; biocides; pest repellents3,065
6C07FOrganometallic compounds1,884
7C07BGeneral methods of organic chemistry1,263
8C07KPeptides957
9Y02PClimate change mitigation: production704
10H10KOrganic semiconductors / OLEDs666

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssignee
TERT-BUTYL NITRITE PHARMACEUTICAL COMPOSITION FOR INJECTION, AND PREPARATION METHOD THEREOF2023
Application of copper catalyst in catalyzing reaction of 1-pyridyl indole compound and tert-butyl nitrite2021
Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite2020
Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite2020
TERT-BUTYL NITRIT AS VASODILATOR AND USE THEREOF1993

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Matthias BellerUniversity of Rostock2
2Richard A. J. O’HairThe University of Melbourne2
3Victor RyzhovNorthern Illinois University2
4Yasutaka IshiiKansai University2
5Ryan Patrick McLaughlinSeattle University2
6Satoshi SakaguchiKansai University2
7Ginger E. DutschmanYale University1
8Johannes SchranckUniversity of Rostock1
9Karine BarralUniversity of London1
10A. RosowskyHarvard University1

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of tert-butyl nitrite?

Tert-butyl nitrite has the molecular formula C4H9NO2 and a molecular weight of 103.121.

Which companies hold the most patents involving tert-butyl nitrite?

The leading patent assignees are Merck and Co Inc with 1128 patents, Roche Holding AG with 1001 patents, and Bayer AG with 786 patents.

What is the trend in patent filings for tert-butyl nitrite in recent years?

Patent filings involving tert-butyl nitrite have shown steady growth, increasing from 787 patents in 2016 to 1687 patents in 2024. The trend continued with 1001 filings in 2025.

What are the primary research applications of tert-butyl nitrite based on published papers?

Published research on tert-butyl nitrite covers chemical synthesis and analysis, including efficient conversion of aromatic amines into azides, chemoselective nitration of phenols, synthesis of nitroarenes by metal-free nitration, and catalytic C–H functionalization methods.

What patent classification areas dominate tert-butyl nitrite patents?

The largest patent classification is C07D with 20631 patents, followed by A61P with 17082 patents and A61K with 11712 patents, indicating significant activity in organic compounds, pharmaceuticals, and medicinal chemistry.

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