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Sutent

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid · also: Sunitinib, Sunitinib malate, sunitinib L-malate, PDGF TK antagonist, Sunitinib malate - Bio-X trade mark

FormulaC26H33FN4O7
Mol. weight532.5694
PubChem CID6456015
InChIKeyLBWFXVZLPYTWQI-IPOVEDGCSA-N
SMILESCCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O
19,732Patents
4,413Research papers
1,665Patents - last 3 years
305Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Genentech Inc1,160
2AbbVie Inc533
3F Hoffmann La Roche AG527
4Merck Sharp & Dohme LLC431
5Novartis AG255
6Vertex Pharmaceuticals Inc202
7Bayer Pharma AG182
8Array Biopharma Inc178
9MedImmune Ltd152
10Pfizer Inc142

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)17,186
2A61KMedicinal preparations15,394
3C07DHeterocyclic compounds8,295
4C07KPeptides6,282
5G01NInvestigating / analysing materials2,458
6C12NMicroorganisms, enzymes2,426
7C12QMeasuring/testing involving enzymes1,185
8Y02AClimate change adaptation1,139
9C07CAcyclic and carbocyclic compounds692
10C07BGeneral methods of organic chemistry610

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
ANTICANCER COMBINATION THERAPY USING SUNITINIB MALATE2006Pfizer Corp Belgium39
SUNITINIB HEMI-L-MALATE, POLYMORPHS AND PREPARATION THEREOF, POLYMORPHS OF RACEMIC SUNITINIB MALATE, COMPOSITINS CONTAINING SUNITINIB BASE AND MALIC ACID AND PREPARATION THEREOF2009Teva Pharmaceutical Industries Ltd26
POLYMORPHS OF SUNITINIB BASE AND PROCESSES FOR PREPARATION THEREOF2009Teva Pharmaceutical Industries Ltd17
PROCESS FOR THE PREPARATION OF HIGH PURITY SUNITINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALT2009Natco Pharma Ltd14
PROCESS FOR PREPARATION OF SUNITINIB MALATE AND SALTS THEREOF2012BHIRUD, SHEKHAR BHASKAR12

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Renal cell carcinoma treatment48
2Gastrointestinal Tumor Research and Treatment9
3Colorectal Cancer Treatments and Studies5
4Neuroendocrine Tumor Research Advances3
5Angiogenesis and VEGF in Cancer2
6HER2/EGFR in Cancer Research2
7Lung Cancer Treatments and Mutations2
8Sarcoma Diagnosis and Treatment2
9Acute Myeloid Leukemia Research1
10Adrenal and Paraganglionic Tumors1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Robert J. MotzerMemorial Sloan Kettering Cancer Center136
2Brian I. RiniCleveland Clinic133
3Toni K. ChoueiriDana-Farber Cancer Institute87
4Bernard EscudierInstitut Gustave Roussy71
5Camillo PortaUniversity of Pavia55
6Alain RavaudHôpital Saint-André38
7Thomas PowlesQueen Mary University of London38
8Stéphane OudardHôpital Européen Georges-Pompidou34
9David F. McDermottBeth Israel Deaconess Medical Center28
10Laurence AlbigèsInstitut Gustave Roussy26

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Sutent?

Sutent has the molecular formula C26H33FN4O7 and a molecular weight of 532.5694 Da. The compound is also known by its chemical name N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid, and is commonly referred to as sunitinib malate or sunitinib L-malate.

Which organizations hold the most patents related to Sutent?

Genentech Inc leads with 1,160 patents, followed by AbbVie Inc with 533 patents and F Hoffmann La Roche AG with 527 patents. Other significant patent holders include Merck Sharp and Dohme LLC with 431 patents and Novartis AG with 255 patents.

What are the primary clinical research topics associated with Sutent?

Renal cell carcinoma treatment is the dominant research topic with 41 papers, reflecting Sutent's primary clinical application. Additional research areas include gastrointestinal tumor research and treatment, colorectal cancer treatments, neuroendocrine tumor research, and angiogenesis and VEGF in cancer. The compound is also studied in contexts of lung cancer, sarcoma, acute myeloid leukemia, and adrenal/paraganglionic tumors.

Who are the most prolific authors publishing on Sutent?

Robert J. Motzer from Memorial Sloan Kettering Cancer Center leads with 136 papers, followed by Brian I. Rini from Cleveland Clinic with 131 papers and Toni K. Choueiri from Dana-Farber Cancer Institute with 87 papers. Bernard Escudier from Institut Gustave Roussy has 71 papers, and Camillo Porta from University of Pavia has 55 papers on the compound.

What types of patent coverage exist for Sutent formulations and preparations?

Patents cover diverse aspects including anticancer combination therapy using sunitinib malate, polymorphs of sunitinib base and hemi-L-malate formulations, preparation methods, processes for producing high-purity sunitinib and its pharmaceutically acceptable salts, and preparation of sunitinib malate and related salts. The patent landscape encompasses 19,732 total patents with 1,715 filed in the last three years.

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