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Sutent

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid · also: Sutent (TN) · Sunitinib malate · PDGF TK antagonist · Sunitinib (Malate) · sunitinib L-malate · Sutent (TN) (Pfizer)

FormulaC26H33FN4O7
Mol. weight532.5694
PubChem CID6456015
InChIKeyLBWFXVZLPYTWQI-IPOVEDGCSA-N
SMILESCCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O
19,732Patents
4,413Research papers4,415 indexed in detail
1,493Patents - last 3 years
305Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Roche Holding AG1,581
2Merck and Co Inc648
3AbbVie Inc608
4Pfizer Inc375
5Novartis AG287
6Bayer AG284
7AstraZeneca PLC271
8Bristol Myers Squibb Co261
9Vertex Pharmaceuticals Inc233
10Daiichi Sankyo Co Ltd228

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)17,187
2A61KMedicinal preparations15,395
3C07DHeterocyclic compounds8,295
4C07KPeptides6,282
5G01NInvestigating / analysing materials2,458
6C12NMicroorganisms, enzymes2,426
7C12QMeasuring/testing involving enzymes1,185
8Y02AClimate change adaptation1,140
9C07CAcyclic and carbocyclic compounds692
10C07BGeneral methods of organic chemistry611

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
ANTICANCER COMBINATION THERAPY USING SUNITINIB MALATE2006Pfizer Inc39
SUNITINIB HEMI-L-MALATE, POLYMORPHS AND PREPARATION THEREOF, POLYMORPHS OF RACEMIC SUNITINIB MALATE, COMPOSITINS CONTAINING SUNITINIB BASE AND MALIC ACID AND PREPARATION THEREOF2009Teva Pharmaceutical Industries Ltd26
PROCESS FOR PREPARATION OF SUNITINIB MALATE AND SALTS THEREOF201212
NEW CRYSTAL FORM OF SUNITINIB MALATE2010Sandoz Group AG10
Anticancer combination therapy using sunitinib malate2008Pfizer Inc10

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
2016281
2017229
2018225
2019230
2020191
2021156
2022172
2023135
2024125
202545

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Robert J. MotzerMemorial Sloan Kettering Cancer Center136
2Brian I. RiniCleveland Clinic133
3Toni K. ChoueiriDana-Farber Cancer Institute99
4Bernard EscudierInstitut Gustave Roussy69
5Camillo PortaUniversity of Pavia55
6Stéphane OudardHôpital Européen Georges-Pompidou40
7Alain RavaudHôpital Saint-André38
8Thomas PowlesQueen Mary University of London29
9David F. McDermottBeth Israel Deaconess Medical Center28
10Patrick SchöffskiKU Leuven28

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition and molecular formula of Sutent?

Sutent is a compound with the molecular formula C26H33FN4O7 and a molecular weight of 532.5694. Its canonical name is N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid. It is also known as sunitinib malate, and exists as the L-malate salt form of the active sunitinib base.

Which organizations hold the most patents related to Sutent?

The leading patent assignees for Sutent-related compounds include Roche Holding AG with 1,581 patents, Merck and Co Inc with 648 patents, and AbbVie Inc with 608 patents. Other significant assignees include Pfizer Inc, Novartis AG, Bayer AG, AstraZeneca PLC, Bristol Myers Squibb Co, Vertex Pharmaceuticals Inc, and Daiichi Sankyo Co Ltd.

What are the major clinical research areas associated with Sutent?

The most highly cited papers on Sutent focus on renal cell carcinoma treatment and cancer immunotherapy combinations. Key research includes comparisons of sunitinib with other treatments in advanced renal-cell carcinoma, as well as its use in gastrointestinal stromal tumors. Notable papers compare sunitinib to interferon alfa, nivolumab plus ipilimumab, pembrolizumab plus axitinib, and avelumab plus axitinib in advanced renal-cell carcinoma settings.

Who are the leading researchers publishing on Sutent?

The most prolific authors publishing on Sutent include Robert J. Motzer from Memorial Sloan Kettering Cancer Center with 136 papers, Brian I. Rini from Cleveland Clinic with 133 papers, and Toni K. Choueiri from Dana-Farber Cancer Institute with 99 papers. Other significant contributors include Bernard Escudier from Institut Gustave Roussy, Camillo Porta from University of Pavia, and Stéphane Oudard from Hôpital Européen Georges-Pompidou.

What is the patent landscape trend for Sutent-related compounds in recent years?

Patent activity related to Sutent peaked in 2019 with 1,362 patents filed, with sustained high activity from 2016 to 2023. Activity has declined in recent years, with 974 patents in 2024 and only 165 in 2025. Over the last three years (2023-2025), there have been 1,493 total patents filed. Paper publications have similarly shown a declining trend, with 305 papers published in the last three years compared to higher volumes in earlier years.

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