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Sutent

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid · also: Sutent (TN), Sunitinib malate, PDGF TK antagonist, Sunitinib (Malate), sunitinib L-malate, Sutent (TN) (Pfizer)

FormulaC26H33FN4O7
Mol. weight532.5694
PubChem CID6456015
InChIKeyLBWFXVZLPYTWQI-IPOVEDGCSA-N
SMILESCCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O
19,732Patents
4,413Research papers
1,591Patents - last 3 years
305Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Genentech Inc1,160
2AbbVie Inc533
3F Hoffmann La Roche AG527
4Merck Sharp & Dohme LLC431
5Novartis AG255
6Vertex Pharmaceuticals Inc202
7Bayer Pharma AG182
8Array Biopharma Inc178
9MedImmune Ltd152
10Pfizer Inc142

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)17,186
2A61KMedicinal preparations15,394
3C07DHeterocyclic compounds8,295
4C07KPeptides6,282
5G01NInvestigating / analysing materials2,458
6C12NMicroorganisms, enzymes2,426
7C12QMeasuring/testing involving enzymes1,185
8Y02AClimate change adaptation1,139
9C07CAcyclic and carbocyclic compounds692
10C07BGeneral methods of organic chemistry610

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
ANTICANCER COMBINATION THERAPY USING SUNITINIB MALATE2006Pfizer Corp Belgium39
SUNITINIB HEMI-L-MALATE, POLYMORPHS AND PREPARATION THEREOF, POLYMORPHS OF RACEMIC SUNITINIB MALATE, COMPOSITINS CONTAINING SUNITINIB BASE AND MALIC ACID AND PREPARATION THEREOF2009Teva Pharmaceutical Industries Ltd26
PROCESS FOR PREPARATION OF SUNITINIB MALATE AND SALTS THEREOF2012BHIRUD, SHEKHAR BHASKAR12
NEW CRYSTAL FORM OF SUNITINIB MALATE2010Lek Pharmaceuticals dd10
Anticancer combination therapy using sunitinib malate2008Pfizer Inc10

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Renal cell carcinoma treatment65
2Gastrointestinal Tumor Research and Treatment12
3Colorectal Cancer Treatments and Studies5
4Angiogenesis and VEGF in Cancer4
5Neuroendocrine Tumor Research Advances4
6Sarcoma Diagnosis and Treatment4
7HER2/EGFR in Cancer Research2
8Hepatocellular Carcinoma Treatment and Prognosis2
9Lung Cancer Treatments and Mutations2
10Pancreatic and Hepatic Oncology Research2

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Robert J. MotzerMemorial Sloan Kettering Cancer Center136
2Brian I. RiniCleveland Clinic133
3Toni K. ChoueiriDana-Farber Cancer Institute87
4Bernard EscudierInstitut Gustave Roussy71
5Camillo PortaUniversity of Pavia55
6Alain RavaudHôpital Saint-André38
7Thomas PowlesQueen Mary University of London38
8Stéphane OudardHôpital Européen Georges-Pompidou34
9David F. McDermottBeth Israel Deaconess Medical Center28
10Laurence AlbigèsInstitut Gustave Roussy26

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Sutent?

Sutent is a compound with the molecular formula C26H33FN4O7 and a molecular weight of 532.5694. Its canonical name is N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid. It is also known as sunitinib malate, combining the sunitinib base with L-malate salt.

Which organizations hold the most patents related to Sutent?

The leading patent holders in the Sutent field are Genentech Inc with 1160 patents, AbbVie Inc with 533 patents, and F Hoffmann La Roche AG with 527 patents. Other significant patent holders include Merck Sharp & Dohme LLC with 431 patents and Novartis AG with 255 patents.

What are the primary clinical applications documented for Sutent in the research literature?

The primary documented application is renal cell carcinoma treatment, which accounts for 65 papers in the literature. Additional research focuses on gastrointestinal tumor research and treatment, with 12 papers, as well as studies on colorectal cancer treatments, angiogenesis and VEGF in cancer, neuroendocrine tumor research, and sarcoma diagnosis and treatment.

Who are the leading clinical researchers publishing on Sutent?

The most prolific authors in Sutent research are Robert J. Motzer from Memorial Sloan Kettering Cancer Center with 136 papers, Brian I. Rini from Cleveland Clinic with 133 papers, and Toni K. Choueiri from Dana-Farber Cancer Institute with 87 papers. Bernard Escudier from Institut Gustave Roussy and Camillo Porta from University of Pavia are also major contributors with 71 and 55 papers respectively.

What is the scale of intellectual property and scientific publication activity around Sutent?

Sutent has extensive IP and research coverage with 19,732 total patents and 4,413 papers in the combined database. In the last three years, there were 1,591 new patents and 305 papers published. The most cited papers exceed 5,700 citations, including a 2007 study on sunitinib versus interferon alfa in metastatic renal-cell carcinoma.

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