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Stattic

6-nitro-1-benzothiophene 1,1-dioxide · also: 6-nitro-1 · 6-nitrobenzothiophene 1,1-dioxide · 6-nitro-1H-1-benzothiophene-1,1-dione · 6-nitro-1lambda6-benzothiophene-1,1-dione

FormulaC8H5NO4S
Mol. weight211.191
PubChem CID2779853
InChIKeyZRRGOUHITGRLBA-UHFFFAOYSA-N
SMILESC1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
951Patents
181Research papers
133Patents - last 3 years
30Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Henkel AG and Co KGaA169
2Fujifilm Holdings Corp49
3BASF SE39
4Memorial Sloan Kettering Cancer Center16
5Yale University13
6Takeda Pharmaceutical Co Ltd11
7Bayer AG10
8Sumitomo Chemical Co Ltd10
9The University of Texas System10
10Institut National de la Santé et de la Recherche Médicale9

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations561
2A61PTherapeutic activity (drug indications)420
3C07DHeterocyclic compounds297
4A61QCosmetics, personal care218
5C07KPeptides103
6G01NInvestigating / analysing materials85
7C09B80
8C12NMicroorganisms, enzymes77
9C07CAcyclic and carbocyclic compounds54
10G03C32

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Improved 6-nitro-1-diazo-2-naphthol-4-sulphonic acid production process20169
Method for performing Fenton treatment on 6-nitro-1-diazo-2-naphthol-4-sulfonic acid wastewater and coproducing sodium sulfate20165
Method and equipment for continuously producing 6-nitro-1, 2, 4-acid oxygen20221
Method for preparing 6-nitro-1, 2-diazoxynaphthalene-4-sulfonic acid20151
Preparation method of 6-nitro-1, 2, 3, 3-tetramethyl benzpyrole20160

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20169
201712
201811
201917
202021
20219
202214
202315
202414
20251

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Patricia DranchakNational Center for Advancing Translational Sciences4
2Jamal MohammadianTabriz University of Medical Sciences3
3Jiayuh LinThe Ohio State University3
4Pui‐Kai LiThe Ohio State University3
5Mehdi SabzichiUniversity of Alberta3
6Rainer SchulzJustus-Liebig-Universität Gießen2
7Adam YasgarNational Institutes of Health2
8Serge GoupilUniversité Laval2
9Sander BuskerKarolinska Institutet2
10Afsaneh LavasanifarUniversity of Alberta2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and structure of Stattic?

Stattic has the molecular formula C8H5NO4S with a molecular weight of 211.191. Its canonical chemical name is 6-nitro-1-benzothiophene 1,1-dioxide, also known as 6-nitro-1H-1-benzothiophene-1,1-dione. The compound's InChI Key is ZRRGOUHITGRLBA-UHFFFAOYSA-N.

What is the primary research application of Stattic based on published literature?

The most highly cited paper on Stattic describes it as a small-molecule inhibitor of STAT3 activation and dimerization, with over 1,100 citations. Subsequent research has applied Stattic to study STAT3 signaling in contexts including cancer cell proliferation, osteoarthritis treatment, immune response to inflammation, and cardioprotection during ischemia/reperfusion injury.

Which organizations hold the most patents involving Stattic?

Henkel AG and Co KGaA leads with 169 patents, followed by Fujifilm Holdings Corp with 49 patents and BASF SE with 39 patents. Among research institutions, Memorial Sloan Kettering Cancer Center holds 16 patents, Yale University holds 13 patents, and The University of Texas System holds 10 patents.

How has patent activity around Stattic evolved in recent years?

Patent filings involving Stattic showed significant growth, with 33 patents in 2016 rising to a peak of 105 patents in 2022, followed by 75 patents in 2023 and 68 patents in 2024. Over the last three years (2022-2024), 248 patents have been filed. In 2025 and 2026, activity has decreased to 37 and 12 patents respectively.

What are the primary CPC technology classifications associated with Stattic patents?

Stattic patents are predominantly classified under A61K (medicinal preparations) with 561 patents, followed by A61P (therapeutic applications) with 420 patents and C07D (heterocyclic compounds) with 297 patents. Other significant classifications include A61Q (cosmetics, personal hygiene, 218 patents), C07K (peptides, 103 patents), and G01N (analytical biology and testing, 85 patents).

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