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Stattic

6-nitro-1-benzothiophene 1,1-dioxide · also: 6-nitro-1, 6-nitrobenzothiophene 1,1-dioxide, 6-nitro-1H-1-benzothiophene-1,1-dione, 6-nitro-1lambda6-benzothiophene-1,1-dione

FormulaC8H5NO4S
Mol. weight211.191
PubChem CID2779853
InChIKeyZRRGOUHITGRLBA-UHFFFAOYSA-N
SMILESC1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
951Patents
181Research papers
138Patents - last 3 years
30Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Henkel AG and Co KGaA169
2Fujifilm Holdings Corp49
3BASF Schweiz AG29
4Memorial Sloan Kettering Cancer Center16
5Yale University13
6Takeda Pharmaceutical Co Ltd11
7BASF SE10
8Sumitomo Pharma Co Ltd10
9The University of Texas System10
10Institut National de la Santé et de la Recherche Médicale9

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations561
2A61PTherapeutic activity (drug indications)420
3C07DHeterocyclic compounds297
4A61QCosmetics, personal care218
5C07KPeptides103
6G01NInvestigating / analysing materials85
7C09B80
8C12NMicroorganisms, enzymes77
9C07CAcyclic and carbocyclic compounds54
10G03C32

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Improved 6-nitro-1-diazo-2-naphthol-4-sulphonic acid production process2016ZHEJIANG QICAI ENVIRONMENT TECHNOLOGY CO., LTD.9
Method for performing Fenton treatment on 6-nitro-1-diazo-2-naphthol-4-sulfonic acid wastewater and coproducing sodium sulfate2016Zhejiang Run Tu research institute company limited5
Method and equipment for continuously producing 6-nitro-1, 2, 4-acid oxygen2022ZHEJIANG DAJING CHEMICAL CO.,LTD.1
Method for preparing 6-nitro-1, 2-diazoxynaphthalene-4-sulfonic acid2015LI FENGYAN1
Preparation method of 6-nitro-1, 2, 3, 3-tetramethyl benzpyrole2016JIANGSU DINGLONG TECHNOLOGY CO., LTD.0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Bioactive Compounds and Antitumor Agents1
2Cytokine Signaling Pathways and Interactions1
3Immune Response and Inflammation1
4Immune cells in cancer1
5MicroRNA in disease regulation1
6Nanoparticle-Based Drug Delivery1
7Neuroinflammation and Neurodegeneration Mechanisms1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Anton SimeonovNational Center for Advancing Translational Sciences4
2James IngleseNational Center for Advancing Translational Sciences4
3Ajit JadhavNational Center for Advancing Translational Sciences3
4Chenglong LiThe Ohio State University3
5Dingyin TaoNational Institutes of Health2
6Fei ChenWayne State University3
7Gerd HeuschEssen University Hospital3
8Jamal MohammadianTabriz University of Medical Sciences3
9Jiayuh LinThe Ohio State University3
10Mehdi SabzichiUniversity of Alberta3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical structure and molecular formula of Stattic?

Stattic, with canonical name 6-nitro-1-benzothiophene 1,1-dioxide, has the molecular formula C8H5NO4S and a molecular weight of 211.191. It is also known by several alternative names including 6-nitro-1H-1-benzothiophene-1,1-dione and 6-nitro-1lambda6-benzothiophene-1,1-dione.

What is the primary biological activity of Stattic?

Stattic functions as a small-molecule inhibitor of STAT3 activation and dimerization, as described in a landmark 2006 publication that has been cited over 1100 times. The compound has been studied extensively in contexts including cancer signaling pathways, inflammatory responses, and STAT3-dependent cellular processes.

Which organizations hold the most patents related to Stattic?

The leading patent assignees for Stattic-related compounds are Henkel AG and Co KGaA with 169 patents, followed by Fujifilm Holdings Corp with 49 patents, and BASF Schweiz AG with 29 patents. Academic institutions and research centers including Memorial Sloan Kettering Cancer Center, Yale University, and The University of Texas System also hold significant patent portfolios in this area.

What research topics are most prominent in Stattic literature?

Published research on Stattic covers multiple disease and biological areas, including Immune Response and Inflammation, Cytokine Signaling Pathways and Interactions, Neuroinflammation and Neurodegeneration Mechanisms, and Nanoparticle-Based Drug Delivery. Notable studies have examined STAT3's role in osteoarthritis treatment, colon cancer cells, cardiac ischemia protection, and lipopolysaccharide-induced immune responses.

How has research and patent activity around Stattic evolved recently?

Patent activity related to Stattic showed significant growth in 2022 with 105 patents filed, compared to 33 in 2016. Over the past three years, 138 patents and 30 peer-reviewed papers have been published. Scientific publications peaked at 21 papers in 2020 and have maintained steady output at 14-15 papers annually through 2024.

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