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Stattic

6-nitro-1-benzothiophene 1,1-dioxide · also: Stat three inhibitory compound

FormulaC8H5NO4S
Mol. weight211.191
PubChem CID2779853
InChIKeyZRRGOUHITGRLBA-UHFFFAOYSA-N
SMILESC1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
951Patents
181Research papers
143Patents - last 3 years
30Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Henkel AG and Co KGaA169
2Fujifilm Holdings Corp49
3BASF Schweiz AG29
4Memorial Sloan Kettering Cancer Center16
5Yale University13
6Takeda Pharmaceutical Co Ltd11
7BASF SE10
8Sumitomo Pharma Co Ltd10
9The University of Texas System10
10Institut National de la Santé et de la Recherche Médicale9

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations561
2A61PTherapeutic activity (drug indications)420
3C07DHeterocyclic compounds297
4A61QCosmetics, personal care218
5C07KPeptides103
6G01NInvestigating / analysing materials85
7C09B80
8C12NMicroorganisms, enzymes77
9C07CAcyclic and carbocyclic compounds54
10G03C32

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Cytokine Signaling Pathways and Interactions1
2Immune Response and Inflammation1
3MicroRNA in disease regulation1
4Nanoparticle-Based Drug Delivery1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Anton SimeonovNational Center for Advancing Translational Sciences4
2James IngleseNational Center for Advancing Translational Sciences4
3Ajit JadhavNational Center for Advancing Translational Sciences3
4Chenglong LiThe Ohio State University3
5Dingyin TaoNational Institutes of Health2
6Fei ChenWayne State University3
7Gerd HeuschEssen University Hospital3
8Jamal MohammadianTabriz University of Medical Sciences3
9Jiayuh LinThe Ohio State University3
10Mehdi SabzichiUniversity of Alberta3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical structure and molecular composition of Stattic?

Stattic, also known as 6-nitro-1-benzothiophene 1,1-dioxide, has the molecular formula C8H5NO4S with a molecular weight of 211.191. Its InChI Key is ZRRGOUHITGRLBA-UHFFFAOYSA-N.

What is the primary biological mechanism of action for Stattic?

Stattic is a small-molecule inhibitor of STAT3 activation and dimerization. It has been studied for its role in inhibiting STAT3-related signaling pathways, including those involved in cytokine signaling and immune responses.

Which organizations hold the most patent rights related to Stattic?

Henkel AG and Co KGaA holds the largest patent portfolio with 169 patents, followed by Fujifilm Holdings Corp with 49 patents and BASF Schweiz AG with 29 patents. Academic institutions including Memorial Sloan Kettering Cancer Center, Yale University, and University of Texas System also hold significant patent positions with 16, 13, and 10 patents respectively.

What therapeutic applications have been explored for Stattic in peer-reviewed literature?

Published research demonstrates Stattic's potential in multiple therapeutic areas. Studies have investigated its use in cancer cell proliferation and colon cancer–initiating cells, osteoarthritis treatment through IL-6/STAT3 signaling inhibition, cardioprotection in myocardial ischemia/reperfusion injury, and modulation of inflammatory responses through STAT3 tyrosine phosphorylation. The highest-cited study on Stattic's mechanism of STAT3 inhibition has received 1110 citations since 2006.

How has patent and publication activity around Stattic changed in recent years?

Patent filings peaked in 2022 with 105 patents, with 144 patents filed in the last three years overall. Publication activity has remained relatively steady, with 30 papers in the last three years out of a total of 181 papers. The compound has sustained research interest across both commercial and academic sectors, with 951 total patents and 181 peer-reviewed papers in the aggregate.

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