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Salsoline

(1R)-7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol · also: D-salosine · D-Salsoline · (+)-salsoline · (R)-salsoline · (+-)-Salsoline · methylsalsolinol

FormulaC11H15NO2
Mol. weight193.246
PubChem CID40010
InChIKeyYTPRLBGPGZHUPD-SSDOTTSWSA-N
SMILESC[C@@H]1C2=CC(=C(C=C2CCN1)O)OC
58Patents
56Research papers
7Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Wanhua Chemical Group Co Ltd2
2Sony Group Corp1
3State University System of Florida1
4University of California1
5Wacker Chemie AG1

Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations16
2A61PTherapeutic activity (drug indications)12
3C07DHeterocyclic compounds10
4G01NInvestigating / analysing materials7
5Y02PClimate change mitigation: production7
6Y02AClimate change adaptation6
7C07CAcyclic and carbocyclic compounds5
8B01JChemical/physical processes (e.g. catalysts)4
9C07BGeneral methods of organic chemistry4
10C07FOrganometallic compounds4

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssignee
Process for extracting salsoline from Common Russianthistle Herb2012
Method extracting salsoline A from salsola collina2012
Preparation method of salsoline2011

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20191

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Makoto NaoiInstitute of Applied Biochemistry28
2Wakako MaruyamaNational Center for Geriatrics and Gerontology20
3W. MaruyamaNational Center for Geriatrics and Gerontology11
4P. DostertStructure Fédérative de Recherche en Biologie et Santé de Rennes9
5Tsutomu TakahashiAichi Konan College8
6Yukihiro AkaoNational Institute of Biotechnology7
7Hong YiNational Institute of Biotechnology7
8Yulin DengNagoya Institute of Technology7
9Yoshihito NakagawaOsaka Medical and Pharmaceutical University3
10Moussa B. H. YoudimTechnion – Israel Institute of Technology3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition and structure of salsoline?

Salsoline has the molecular formula C11H15NO2 with a molecular weight of 193.246. Its canonical IUPAC name is (1R)-7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol, and it is also known by several synonyms including D-salsoline, (+)-salsoline, and methylsalsolinol. The compound is identified by the InChI Key YTPRLBGPGZHUPD-SSDOTTSWSA-N.

Which organizations hold patents on salsoline?

Patent assignees for salsoline include Wanhua Chemical Group Co Ltd (2 patents), Sony Group Corp, State University System of Florida, University of California, and Wacker Chemie AG (each with 1 patent). Additionally, several patents exist without listed assignees, including processes for extracting salsoline from plant sources such as Common Russianthistle Herb and Salsola collina.

What research areas are most relevant to salsoline patents and publications?

Patents are predominantly classified under pharmaceutical (A61K, A61P) and organic chemistry categories (C07D, C07C), with 16 patents in A61K, 12 in A61P, and 10 in C07D. Analytical chemistry and chromatography methods (G01N) account for 7 patents. Published research focuses on neuroscience and neuropharmacology, including studies on dopamine neurotoxicity and Parkinson's disease, with papers such as 'Cell death of dopamine neurons in aging and Parkinson's disease' and 'A dopaminergic neurotoxin, (R)‐N‐methylsalsolinol, increases in parkinsonian cerebrospinal fluid'.

Who are the most prolific researchers publishing on salsoline?

Leading authors in salsoline research include Makoto Naoi from the Institute of Applied Biochemistry with 28 papers, Wakako Maruyama from the National Center for Geriatrics and Gerontology with 20 papers, and W. Maruyama also from the National Center for Geriatrics and Gerontology with 11 papers. Other significant contributors include P. Dostert, Tsutomu Takahashi, Yukihiro Akao, Hong Yi, and Yulin Deng, each with between 7 and 9 publications.

What is the patent and publication activity trend for salsoline?

Patent activity on salsoline has been relatively consistent, with 3 to 4 patents filed annually between 2017 and 2024, and 3 patents in 2025. Total patent coverage includes 58 patents, with 7 patents filed in the last 3 years. Academic publishing shows minimal recent activity, with 56 total papers identified but no papers published in the last 3 years, with the most recent significant publication appearing in 2019.

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