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Prograf

(18E)-1,14-dihydroxy-12-[(E)-1-(4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone · also: Protopy, Protopic, Advagraf, Fujimycin, LCP-Tacro, tacrolimus

FormulaC44H69NO12
Mol. weight804.031
PubChem CID6536850
InChIKeyQJJXYPPXXYFBGM-FWWCNTFXSA-N
SMILESCC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(/C=C(/C1)\C)CC=C)O)C)/C(=C/C4CCC(C(C4)OC)O)/C)O)C)OC)OC
31Patents
18,646Research papers
0Patents - last 3 years
993Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Astellas Pharma Inc18
2Sucampo GmbH5
3Daiichi Sankyo Co Ltd3
4Emory University2
5Sankyo Co Ltd1

Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations25
2A61PTherapeutic activity (drug indications)22
3C07DHeterocyclic compounds8
4Y02PClimate change mitigation: production5
5C07FOrganometallic compounds4
6C07HSugars and derivatives3
7A61LSterilising / disinfecting materials2
8B01D2
9B01JChemical/physical processes (e.g. catalysts)2
10C07CAcyclic and carbocyclic compounds2

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Renal Transplantation Outcomes and Treatments111
2Signaling Pathways in Disease75
3Dermatology and Skin Diseases24
4Organ Transplantation Techniques and Outcomes24
5Transplantation: Methods and Outcomes15
6Pancreatic function and diabetes11
7Neurological Complications and Syndromes10
8Renal Diseases and Glomerulopathies8
9Drug Transport and Resistance Mechanisms7
10melanin and skin pigmentation7

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1John J. FungUniversity of Pittsburgh283
2Thomas E. StarzlUniversity of Pittsburgh271
3Satoru TodoUniversity of Pittsburgh88
4Ron ShapiroUniversity of Pittsburgh86
5P. NeuhausHumboldt-Universität zu Berlin79
6Andreas G. TzakisUniversity of Miami74
7Dirk KuypersKU Leuven59
8Raman VenkataramananUniversity of Pittsburgh55
9Anthony J. DemetrisUniversity of Pittsburgh50
10Lionel RostaingHôpital Rangueil48

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Prograf?

Prograf has the molecular formula C44H69NO12 and a molecular weight of 804.031 Da.

Which organizations hold the most patents for Prograf?

Astellas Pharma Inc holds 18 patents related to Prograf, followed by Sucampo GmbH with 5 patents and Daiichi Sankyo Co Ltd with 3 patents.

What are the primary research topics associated with Prograf studies?

The primary research topics include Renal Transplantation Outcomes and Treatments with 100 papers, Signaling Pathways in Disease with 69 papers, and Dermatology and Skin Diseases with 22 papers.

Who are the most prolific authors publishing research on Prograf?

John J. Fung from University of Pittsburgh has published 282 papers, followed by Thomas E. Starzl from University of Pittsburgh with 271 papers, and Satoru Todo from University of Pittsburgh with 88 papers.

What is the current patent and publication activity for Prograf?

There have been no patents filed in the last 3 years, while publication activity remains substantial with 992 papers published in the last 3 years. The aggregate includes 31 total patents and 18,537 papers matched to the compound.

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