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Pregnane

(8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene · also: Pregnane skeleton

FormulaC21H36
Mol. weight288.519
PubChem CID6857422
InChIKeyJWMFYGXQPXQEEM-WZBAXQLOSA-N
SMILESCC[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4[C@@]3(CCCC4)C)C
6,874Patents
1,645Research papers1,643 indexed in detail
431Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Symrise AG360
2Samsung Biologics Co Ltd252
3Coca-Cola Co236
4Roche Holding AG205
5Bayer AG159
6Merck and Co Inc156
7Novartis AG138
8Sanofi SA135
9Ingredion Inc100
10Pfizer Inc99

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations3,054
2A61PTherapeutic activity (drug indications)2,879
3C07J2,460
4C12NMicroorganisms, enzymes741
5C07KPeptides638
6C07DHeterocyclic compounds565
7A61QCosmetics, personal care529
8G01NInvestigating / analysing materials418
9A23LFoods and beverages (general)415
10C07CAcyclic and carbocyclic compounds320

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
3,3 DISUBSTITUTED 19-NOR PREGNANE COMPOUNDS, COMPOSITIONS, AND USES THEREOF2013Supernus Pharmaceuticals Inc172
Neuroactive steroids of the androstane and pregnane series1999Purdue Pharma LP170
Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series1999Purdue Pharma LP162
Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series1993University of Southern California160
Methods for allosteric modulation of the GABA receptor by members of the androstane and pregnane series2001Purdue Pharma LP108

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Curtis D. KlaassenUniversity of Kansas Medical Center23
2Jean‐Marc PascussiInserm22
3Masahiko NegishiNational Institute of Environmental Health Sciences22
4Wen XieUniversity of Pittsburgh21
5Jeff L. StaudingerUniversity of Kansas20
6Erin G. SchuetzSt. Jude Children's Research Hospital16
7Matthew R. RedinboUniversity of North Carolina at Chapel Hill16
8Frank J. GonzalezNational Institutes of Health15
9Sean EkinsUniversity of Maryland, Baltimore13
10Nick PlantUniversity of Surrey12

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Nuclear Receptors and Lipid Physiology: Opening the X-Files20012082Peroxisome Proliferator-Activated Receptors
Induction of phase I, II and III drug metabolism/transport by xenobiotics20051270Pharmacogenetics and Drug Metabolism
Vitamin D Receptor As an Intestinal Bile Acid Sensor20021172Vitamin D Research Studies
Neurosteroids: endogenous regulators of the GABAA receptor20051157Neuroscience and Neuropharmacology Research
Hormone Therapy and Venous Thromboembolism Among Postmenopausal Women2007852Venous Thromboembolism Diagnosis and Management

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Pregnane?

Pregnane has the molecular formula C21H36 with a molecular weight of 288.519. Its canonical name is (8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene, and it is also referred to by the synonym Pregnane skeleton.

Which companies have the most patents related to Pregnane?

The leading patent assignees for Pregnane are Symrise AG with 360 patents, Samsung Biologics Co Ltd with 252 patents, and Coca-Cola Co with 236 patents. Other major assignees include Roche Holding AG (205 patents), Bayer AG (159 patents), Merck and Co Inc (156 patents), Novartis AG (138 patents), Sanofi SA (135 patents), Ingredion Inc (100 patents), and Pfizer Inc (99 patents).

What are the most-cited patents in the Pregnane literature?

The most-cited Pregnane patents are US-5232917-A titled Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series (160 citations), US-5939545-A on Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series (162 citations), and US-5925630-A on Neuroactive steroids of the androstane and pregnane series (170 citations).

What research topics are most associated with Pregnane in the published literature?

Key research topics in Pregnane literature include Neurosteroids and GABAA receptor regulation, as reflected in highly-cited work Neurosteroids: endogenous regulators of the GABAA receptor (1157 citations). Other important topics include drug metabolism and xenobiotic induction covered in Induction of phase I, II and III drug metabolism/transport by xenobiotics (1270 citations), nuclear receptor function in lipid physiology, and vitamin D receptor biology as an intestinal bile acid sensor.

What patent classifications are most prevalent for Pregnane inventions?

The predominant CPC classifications for Pregnane patents are A61K (pharmaceutical preparations) with 3054 patents, A61P (therapeutic applications) with 2879 patents, and C07J (steroid compounds) with 2460 patents. Other significant classifications include C12N (biotechnology, 741 patents), C07K (peptide compounds, 638 patents), C07D (heterocyclic compounds, 565 patents), and A61Q (specific use of cosmetics/medical preparations, 529 patents).

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