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Pregnane

(8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene · also: Pregnane skeleton

FormulaC21H36
Mol. weight288.519
PubChem CID6857422
InChIKeyJWMFYGXQPXQEEM-WZBAXQLOSA-N
SMILESCC[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4[C@@]3(CCCC4)C)C
6,874Patents
1,645Research papers
458Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Symrise AG345
2Human Genome Sciences Inc252
3Coca-Cola Co236
4Bayer Pharma AG159
5Novartis AG135
6Pharmacia and Upjohn Co88
7Merck and Co Inc76
8Cormatrix Cardiovascular Inc72
9Hoffmann La Roche Inc69
10F Hoffmann La Roche AG67

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations3,054
2A61PTherapeutic activity (drug indications)2,877
3C07J2,460
4C12NMicroorganisms, enzymes741
5C07KPeptides638
6C07DHeterocyclic compounds565
7A61QCosmetics, personal care529
8G01NInvestigating / analysing materials418
9A23LFoods and beverages (general)415
10C07CAcyclic and carbocyclic compounds320

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
3,3 DISUBSTITUTED 19-NOR PREGNANE COMPOUNDS, COMPOSITIONS, AND USES THEREOF2013Sage Therapeutics Inc172
Neuroactive steroids of the androstane and pregnane series1999Purdue Pharma LP170
Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series1999Cocensys Inc162
Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series1993University of Southern California160
Methods for allosteric modulation of the GABA receptor by members of the androstane and pregnane series2001Cocensys Inc108

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Pharmacogenetics and Drug Metabolism29
2Drug Transport and Resistance Mechanisms8
3Computational Drug Discovery Methods2
4Vitamin D Research Studies2
5Vitamin K Research Studies2
6Bladder and Urothelial Cancer Treatments1
7Criminal Justice and Corrections Analysis1
8Ectopic Pregnancy Diagnosis and Management1
9Esophageal Cancer Research and Treatment1
10Estrogen and related hormone effects1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Curtis D. KlaassenUniversity of Kansas Medical Center23
2Jean‐Marc PascussiInserm22
3Masahiko NegishiNational Institute of Environmental Health Sciences22
4Wen XieUniversity of Pittsburgh21
5Frank J. GonzalezNational Institutes of Health15
6Matthew R. RedinboUniversity of North Carolina at Chapel Hill14
7Sean EkinsUniversity of Maryland, Baltimore13
8Patrick MaurelInserm12
9Erin G. SchuetzSt. Jude Children's Research Hospital11
10Steven A. KliewerResearch Triangle Park Foundation11

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Nuclear Receptors and Lipid Physiology: Opening the X-Files20012077Peroxisome Proliferator-Activated Receptors
Induction of phase I, II and III drug metabolism/transport by xenobiotics20051265Pharmacogenetics and Drug Metabolism
Vitamin D Receptor As an Intestinal Bile Acid Sensor20021167Vitamin D Research Studies
Neurosteroids: endogenous regulators of the GABAA receptor20051152Neuroscience and Neuropharmacology Research
Hormone Therapy and Venous Thromboembolism Among Postmenopausal Women2007850Venous Thromboembolism Diagnosis and Management

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition and structure of Pregnane?

Pregnane has the molecular formula C21H36 with a molecular weight of 288.519. Its canonical name is (8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene, and it is also referred to as the Pregnane skeleton.

How extensive is the patent and research literature on Pregnane?

The compound has substantial coverage with 6874 total patents and 1645 papers in the academic literature. In the last 3 years alone, there have been 458 new patents filed, demonstrating continued commercial and research interest.

Which organizations hold the most patents involving Pregnane compounds?

Symrise AG leads with 345 patents, followed by Human Genome Sciences Inc with 252 patents and Coca-Cola Co with 236 patents. Other significant patent holders include Bayer Pharma AG (159 patents), Novartis AG (135 patents), and Pharmacia and Upjohn Co (88 patents).

What are the key research focuses related to Pregnane?

The primary research area is Pharmacogenetics and Drug Metabolism, with 29 papers on this topic. Notable related research areas include Drug Transport and Resistance Mechanisms (8 papers) and Computational Drug Discovery Methods (2 papers). Highly cited foundational work includes studies on nuclear receptors and lipid physiology, phase I/II/III drug metabolism induction, and neurosteroid regulation of the GABAA receptor.

What is the primary patent classification for Pregnane-related inventions?

The largest patent classification is A61K (pharmaceutical preparations) with 3054 patents, followed closely by A61P (therapeutic uses) with 2877 patents and C07J (steroids and related compounds) with 2460 patents. These classifications reflect the compound's importance in pharmaceutical development and steroid chemistry.

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