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Phthalate

phthalate · also: z phthalate · phthalate(2-) · 1,2-Phthalate · Phthalic Acid Ester · 1,2-benzenedicarboxylate · benzene-1,2-dicarboxylate

FormulaC8H4O4-2
PubChem CID181977
InChIKeyXNGIFLGASWRNHJ-UHFFFAOYSA-L
SMILESC1=CC=C(C(=C1)C(=O)[O-])C(=O)[O-]
18,070Patents
3,884Research papers3,887 indexed in detail
856Patents - last 3 years
897Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1China Petrochemical Corp229
2BASF SE218
3Corteva Inc141
4Perrigo Co PLC126
5Bayer AG114
6Eastman Kodak Co114
7Exxon Mobil Corp103
8Pfizer Inc93
9Procter and Gamble Co91
10General Electric Co75

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations3,817
2C08LPolymer compositions (blends)3,464
3C08KPolymer compositions (additives)3,075
4A61PTherapeutic activity (drug indications)2,563
5C08GPolymers from non-vinyl bonds (e.g. polyamides, polyesters)1,382
6C08JWorking-up of plastics1,244
7C08FPolymers from C=C unsaturated bonds1,233
8C09DCoatings, paints, varnishes1,191
9Y10TCross-reference (technical subjects)1,027
10C07CAcyclic and carbocyclic compounds838

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Phenolic resin-polyisocyanate binder systems containing dialkyl phthalate solvents1975Ashland Inc55
A REPLACEMENT PLASTICIZER SYSTEM FOR PHTHALATE-PLASTICIZED FORMULATIONS2009Dow Inc51
Adhesive compositions from phthalate polymers and the preparation thereof199849
Phthalate free nail polish enamel composition1999RPM International Inc45
Self-compatibilizing phthalate-based polyester polyols1987Stepan Co39

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
2016155
2017157
2018200
2019223
2020306
2021330
2022483
2023454
2024329
2025114

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Antonia M. CalafatCenters for Disease Control and Prevention116
2Russ HauserHarvard University52
3John D. MeekerUniversity of Michigan49
4Kurunthachalam KannanNew York State Department of Health46
5Jodi A. FlawsUniversity of Illinois Urbana-Champaign34
6Sheela SathyanarayanaUniversity of Washington31
7Leonardo TrasandeNew York University28
8Joseph M. BraunBrown University25
9Kelly K. FergusonNational Institute of Environmental Health Sciences24
10Paige L. WilliamsHarvard University20

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals20152400Toxic Organic Pollutants Impact
Phthalates: Toxicology and exposure20071487Effects and risks of endocrine disrupting chemicals
What Are the Sources of Exposure to Eight Frequently Used Phthalic Acid Esters in Europeans?20061022Effects and risks of endocrine disrupting chemicals
Plastics and Health Risks2010867Effects and risks of endocrine disrupting chemicals
Phthalates and other additives in plastics: human exposure and associated health outcomes2009821Toxic Organic Pollutants Impact

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition of phthalate?

Phthalate has the molecular formula C8H4O4-2 and is also known as 1,2-benzenedicarboxylate or benzene-1,2-dicarboxylate. It is commonly referred to as phthalic acid ester.

Which organizations hold the most patents related to phthalate?

The leading patent assignees for phthalate-related inventions are China Petrochemical Corp with 229 patents, BASF SE with 218 patents, and Corteva Inc with 141 patents. Other significant patent holders include Perrigo Co PLC, Bayer AG, and Eastman Kodak Co.

What research topics dominate the academic literature on phthalates?

The primary research focus is on the effects and risks of endocrine-disrupting chemicals, with significant attention to toxic organic pollutants impact. Key papers include the Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals, which examines phthalates toxicology and exposure, and studies on sources of exposure to phthalic acid esters in populations.

Who are the most prolific authors publishing on phthalate research?

The leading researcher on phthalates is Antonia M. Calafat with 116 papers, affiliated with the Centers for Disease Control and Prevention. Other prominent authors include Russ Hauser from Harvard University with 52 papers, John D. Meeker from University of Michigan with 49 papers, and Kurunthachalam Kannan from New York State Department of Health with 46 papers.

What are the primary patent classification areas for phthalate-related inventions?

Phthalate patents are concentrated in several technical areas: pharmaceutical and medicinal chemistry (A61K with 3,817 patents), macromolecular chemistry and plastics (C08L with 3,464 patents), and plastic additives and modifiers (C08K with 3,075 patents). Significant patent activity also occurs in pharmaceutical preparations (A61P) and other polymer and paint-related classifications.

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