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PD173955

6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one · also: C21H16cl2N4OS · 6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido(2,3-d)pyrimidin-7-one · 6-(2,6-dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido(2,3-d)pyrimidin-7(8H)-one

FormulaC21H16Cl2N4OS
Mol. weight443.346
PubChem CID447077
InChIKeyVAARYSWULJUGST-UHFFFAOYSA-N
SMILESCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC
198Patents
35Research papers
35Patents - last 3 years
2Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Pfizer Inc28
2Schroedinger Inc14
3Ono Pharmaceutical Co Ltd10
4Roche Holding AG9
5Memorial Sloan Kettering Cancer Center8
6Emory University7
7Eli Lilly and Co6
8Scripps Research Institute5
9Yale University4
10AstraZeneca PLC3

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)169
2A61KMedicinal preparations142
3C07DHeterocyclic compounds89
4C12QMeasuring/testing involving enzymes42
5C07KPeptides37
6C12NMicroorganisms, enzymes35
7G01NInvestigating / analysing materials28
8C12YEnzyme nomenclature (EC numbers)14
9Y02AClimate change adaptation9
10C07BGeneral methods of organic chemistry8

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
PROTEOLYSIS TARGETING CHIMERA COMPOUNDS AND METHODS OF PREPARING AND USING SAME2017Yale University189
Enzyme modulators and treatments2012Ono Pharmaceutical Co Ltd128
CRYSTALLINE FORMS201955
ENZYME MODULATORS AND TREATMENTS2006Ono Pharmaceutical Co Ltd156
SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES2020Pfizer Inc43

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20162
20173
20181
20195
20202
20211
20221
20232

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Anton SimeonovNational Center for Advancing Translational Sciences4
2Kelli M. WilsonNational Center for Advancing Translational Sciences3
3Matthew D. HallNational Institutes of Health3
4Carleen Klumpp‐ThomasNational Center for Advancing Translational Sciences3
5Kyle R. BrimacombeNational Center for Advancing Translational Sciences3
6Ajit JadhavNational Center for Advancing Translational Sciences3
7Alan J. KrakerWarde Medical Laboratory3
8Bayard D. ClarksonMemorial Sloan Kettering Cancer Center3
9Adam YasgarNational Institutes of Health2
10Daniel K. TreiberNational Institutes of Health2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition and structure of PD173955?

PD173955 has the molecular formula C21H16Cl2N4OS with a molecular weight of 443.346. Its IUPAC name is 6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one, and its InChI Key is VAARYSWULJUGST-UHFFFAOYSA-N.

Which organizations hold the most patents involving PD173955?

The leading patent assignees for PD173955 are Pfizer Inc with 28 patents, Schroedinger Inc with 14 patents, and Ono Pharmaceutical Co Ltd with 10 patents. Other significant assignees include Roche Holding AG with 9 patents and Memorial Sloan Kettering Cancer Center with 8 patents.

What are the major research topics associated with PD173955 publications?

Research on PD173955 spans multiple topics including Chronic Lymphocytic Leukemia Research, Protein Kinase Regulation and GTPase Signaling, HER2/EGFR in Cancer Research, and Microtubule and mitosis dynamics. A landmark paper on crystal structures of the kinase domain of c-Abl in complex with PD173955 and imatinib was published in 2002 and has received 942 citations.

How has patent activity around PD173955 evolved in recent years?

Patent activity has increased substantially, with 5 patents in 2016 growing to a peak of 23 in 2022, followed by 18 patents each in 2023 and 2024. In the last three years, there have been 35 patents filed. In contrast, recent paper publications have declined, with only 2 papers published in the last three years.

What patent classification categories are most prominent for PD173955-related patents?

The most frequently used patent classifications are A61P (pharmaceutical preparations for specific therapeutic purposes) with 169 patents, A61K (preparations for medical purposes) with 142 patents, and C07D (heterocyclic compounds) with 89 patents. These are followed by C12Q (measuring or testing bioprocess assays) with 42 patents and C07K (peptides) with 37 patents.

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