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PD173955

6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one · also: C21H16cl2N4OS, 6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido(2,3-d)pyrimidin-7-one, 6-(2,6-dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido(2,3-d)pyrimidin-7(8H)-one

FormulaC21H16Cl2N4OS
Mol. weight443.346
PubChem CID447077
InChIKeyVAARYSWULJUGST-UHFFFAOYSA-N
SMILESCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC
198Patents
35Research papers
36Patents - last 3 years
2Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Array Biopharma Inc28
2Schroedinger Inc14
3Deciphera Pharmaceuticals LLC10
4Foundation Medicine Inc9
5Memorial Sloan Kettering Cancer Center8
6Emory University7
7Loxo Oncology Inc6
8Scripps Research Institute5
9Yale University4
10Acerta Pharma BV3

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)169
2A61KMedicinal preparations142
3C07DHeterocyclic compounds89
4C12QMeasuring/testing involving enzymes42
5C07KPeptides35
6C12NMicroorganisms, enzymes35
7G01NInvestigating / analysing materials28
8C12YEnzyme nomenclature (EC numbers)14
9Y02AClimate change adaptation9
10C07BGeneral methods of organic chemistry8

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Ajit JadhavNational Center for Advancing Translational Sciences4
2Anton SimeonovNational Center for Advancing Translational Sciences4
3Alan J. KrakerWarde Medical Laboratory3
4Bayard D. ClarksonMemorial Sloan Kettering Cancer Center3
5Carleen Klumpp‐ThomasNational Center for Advancing Translational Sciences3
6Kelli M. WilsonNational Center for Advancing Translational Sciences3
7Kyle R. BrimacombeNational Center for Advancing Translational Sciences3
8Matthew D. HallNational Institutes of Health3
9Min ShenNational Institutes of Health3
10A StrifeKettering University2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and structure classification of PD173955?

PD173955 has the molecular formula C21H16Cl2N4OS with a molecular weight of 443.346. The compound is a pyrido[2,3-d]pyrimidine derivative, specifically 6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one.

Which organizations hold the most patents involving PD173955?

Array Biopharma Inc leads with 28 patents, followed by Schroedinger Inc with 14 patents and Deciphera Pharmaceuticals LLC with 10 patents. Other significant patent holders include Foundation Medicine Inc, Memorial Sloan Kettering Cancer Center, and Emory University.

What is the primary research focus of published papers on PD173955?

The most highly cited paper on PD173955 describes crystal structures of the kinase domain of c-Abl in complex with PD173955 and imatinib, with 942 citations. Other papers focus on related topics including Src kinase inhibition, tyrosine kinase regulation, and effects on cancer cell lines, reflecting its role as a kinase inhibitor.

How has patent activity for PD173955 evolved in recent years?

Patent activity has shown growth, with 23 patents filed in 2022 representing the peak year. The last three years (2022-2024) collectively account for 59 patents out of the total 198, indicating sustained commercial and research interest. In 2024 and 2025, activity has moderated to 18 and 13 patents respectively.

What are the main patent classification areas associated with PD173955?

The compound is primarily classified under A61P (169 patents), covering pharmaceutical applications, and A61K (142 patents), covering pharmaceutical preparations. Chemical synthesis classifications C07D (89 patents) and biotechnology-related classifications C12Q, C07K, and C12N (42, 35, and 35 patents respectively) also represent significant portions of the patent landscape.

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