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p-Iodoclonidine

N-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-1H-imidazol-2-amine · also: Lopac-I-114 · 4-iodoclonidine · (2,6-Dichloro-4-iodo-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine · (2,6-Dichloro-4-iodo-phenyl)-imidazolidin-2-ylidene-amine (p-iodoclonidine)

FormulaC9H8Cl2IN3
Mol. weight355.9885
PubChem CID4656
InChIKeyHSRPTPAPMBHRRJ-UHFFFAOYSA-N
SMILESC1CN=C(N1)NC2=C(C=C(C=C2Cl)I)Cl
134Patents
44Research papers
2Patents - last 3 years
1Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Nicox SA21
2Pfizer Inc9
3Acadia Pharmaceuticals Inc7
4Daiichi Sankyo Co Ltd4
5Washington University in St. Louis3
6Kenvue Inc2
7Selvita SA2
8Alcon Inc1
9Avalo Therapeutics Inc1
10Hospital for Sick Children1

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)101
2A61KMedicinal preparations98
3C07DHeterocyclic compounds36
4Y02AClimate change adaptation22
5C07CAcyclic and carbocyclic compounds16
6A61MDevices for introducing media into the body12
7C07KPeptides12
8A61LSterilising / disinfecting materials11
9C08LPolymer compositions (blends)11
10C08B3

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Method for treatment of retinal diseases2000University of California165
Dopamine analog amide2002Daiichi Sankyo Co Ltd121
Preventing neuronal degeneration in Alzheimer's disease1999Washington University in St. Louis115
Dopamine analog amide2001Daiichi Sankyo Co Ltd106
Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH)1997Washington University in St. Louis122

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20163
20194
20202
20211
20221
20231

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1John E. PiletzUniversity of Mississippi Medical Center7
2He ZhuUniversity of Mississippi Medical Center4
3Patricia DranchakNational Center for Advancing Translational Sciences4
4Paul ErnsbergerCase Western Reserve University4
5James IngleseNational Center for Advancing Translational Sciences4
6Jens ScholzUniversity of Lübeck3
7Anton SimeonovNational Center for Advancing Translational Sciences3
8Ajit JadhavNational Center for Advancing Translational Sciences3
9Adam YasgarNational Institutes of Health2
10Danica AgbabaUniversity of Belgrade2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of p-Iodoclonidine?

p-Iodoclonidine has the molecular formula C9H8Cl2IN3 and a molecular weight of 355.9885. Its canonical IUPAC name is N-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-1H-imidazol-2-amine.

Which organizations hold the most patents involving p-Iodoclonidine?

Nicox SA holds the largest patent portfolio with 21 patents, followed by Pfizer Inc with 9 patents and Acadia Pharmaceuticals Inc with 7 patents related to p-Iodoclonidine.

What are the major research areas covered by patents related to p-Iodoclonidine?

The primary patent classification areas are pharmaceutical formulations and therapeutic applications (A61P, with 101 patents) and pharmaceutical active ingredients (A61K, with 98 patents). Organic chemistry synthesis appears frequently (C07D with 36 patents), indicating substantial work on chemical derivatives and synthesis methods.

Who are the most prolific authors publishing on p-Iodoclonidine?

John E. Piletz from University of Mississippi Medical Center is the most prolific author with 7 papers. Other leading contributors include He Zhu (4 papers, University of Mississippi Medical Center), Patricia Dranchak (4 papers, National Center for Advancing Translational Sciences), Paul Ernsberger (4 papers, Case Western Reserve University), and James Inglese (4 papers, National Center for Advancing Translational Sciences).

How has research activity on p-Iodoclonidine changed in recent years?

Patent filings peaked in 2016, 2021, and 2022 (6 patents each), with only 2 patents in the last 3 years. Academic publishing shows a similar pattern with peaks in 2016 (3 papers) and 2019 (4 papers), declining to just 1 paper in the last 3 years, indicating reduced recent research momentum.

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