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Ouabain

3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one;octahydrate · also: Ouabain CRS · G-Strophanthin · Quabain octahydrate · Ouabain octahydrate · G-Strophanthin (JAN) · Ouabain (Octahydrate)

FormulaC29H60O20
Mol. weight728.779
PubChem CID6364534
InChIKeyTYBARJRCFHUHSN-DMJRSANLSA-N
SMILESC[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O.O.O.O.O.O.O.O.O
683Patents
16,433Research papers16,425 indexed in detail
20Patents - last 3 years
63Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Bristol Myers Squibb Co174
2Roche Holding AG36
3Pfizer Inc35
4Alfasigma SpA30
5University of Tennessee System30
6Merck and Co Inc23
7Oncternal Therapeutics Inc20
8Centre National de la Recherche Scientifique16
9Cosciens Biopharma Inc16
10Icagen Inc11

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)533
2C07DHeterocyclic compounds434
3A61KMedicinal preparations320
4C07CAcyclic and carbocyclic compounds108
5G01NInvestigating / analysing materials67
6C07FOrganometallic compounds50
7C12QMeasuring/testing involving enzymes46
8C07J45
9C07HSugars and derivatives41
10C07KPeptides38

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Heterogeneous immunoassay for digoxin using ouabain as a separation means1985Siemens AG41
ASSAY METHODS INVOLVING OUABAIN1992University System of Maryland39
Antibody having binding specificity for human ouabain1998University System of Maryland36
Immunoassay for detecting human ouabain199512
Ouabain triacetate derivative compounds1991Abbott Laboratories4

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
201661
201756
201856
201954
202043
202152
202235
202332
202428
20253

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Tai AkeraMichigan State University67
2John M. HamlynUniversity of Maryland, Baltimore56
3Torben ClausenAarhus University54
4Erland ErdmannLMU Klinikum44
5Arnold SchwartzBaylor College of Medicine39
6Frans H. H. LeenenUniversity of Ottawa36
7Amir AskariUniversity of Toledo Medical Center31
8Mordecai P. BlausteinUniversity of Maryland, Baltimore29
9Paolo ManuntaVita-Salute San Raffaele University29
10Earl T. WallickUniversity of Cincinnati Medical Center24

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Ouabain?

Ouabain has the molecular formula C29H60O20 and a molecular weight of 728.779 g/mol. It is commonly encountered as an octahydrate form.

Which organizations hold the most patents related to Ouabain?

Bristol Myers Squibb Co holds the largest patent portfolio with 174 patents, followed by Roche Holding AG with 36 patents and Pfizer Inc with 35 patents related to Ouabain.

What are the major research areas associated with Ouabain patents?

The primary patent classification areas are pharmaceutical preparations (A61P) with 533 patents, organic chemistry compounds (C07D) with 434 patents, and medicinal chemistry (A61K) with 320 patents, indicating Ouabain's significance in drug development and chemical synthesis.

Who are the most prolific authors publishing research on Ouabain?

The leading researchers include Tai Akera from Michigan State University with 67 papers, John M. Hamlyn from University of Maryland, Baltimore with 56 papers, and Torben Clausen from Aarhus University with 54 papers.

What is the publication trend for Ouabain research over the past decade?

Paper publication peaked in 2016 with 61 publications and has generally declined, with 28 papers in 2024 and 3 in 2025. Patent filings also show a downward trend from a peak of 22 patents in 2017 to 5 in 2025, with only 20 patents filed in the last three years.

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