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Ouabain

3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one;octahydrate · also: Ouabain CRS, G-Strophanthin, Quabain octahydrate, Ouabain octahydrate, G-Strophanthin (JAN), Ouabain (Octahydrate)

FormulaC29H60O20
Mol. weight728.779
PubChem CID6364534
InChIKeyTYBARJRCFHUHSN-DMJRSANLSA-N
SMILESC[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O.O.O.O.O.O.O.O.O
683Patents
16,433Research papers
20Patents - last 3 years
63Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Bristol Myers Squibb Co174
2Sigma Tau Industrie Farmaceutiche Riunite SpA30
3University of Tennessee Research Foundation30
4Bioveris Corp25
5Oncternal Therapeutics Inc20
6Aeterna Zentaris GmbH16
7Centre National de la Recherche Scientifique16
8Pfizer Corp SRL16
9Pfizer Inc16
10Merck Sharp & Dohme LLC15

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)533
2C07DHeterocyclic compounds434
3A61KMedicinal preparations320
4C07CAcyclic and carbocyclic compounds108
5G01NInvestigating / analysing materials67
6C07FOrganometallic compounds50
7C12QMeasuring/testing involving enzymes46
8C07J45
9C07HSugars and derivatives41
10C07KPeptides38

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Heterogeneous immunoassay for digoxin using ouabain as a separation means1985Dade Behring Inc41
ASSAY METHODS INVOLVING OUABAIN1992University of Maryland, Baltimore39
Antibody having binding specificity for human ouabain1998University of Maryland, Baltimore36
Immunoassay for detecting human ouabain1995UNIVERSITY OF MARYLAND AT BALTIMORE12
Ouabain triacetate derivative compounds1991Abbott Laboratories4

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Ion Transport and Channel Regulation80
2Cardiac electrophysiology and arrhythmias24
3Ion channel regulation and function24
4Neuroscience and Neuropharmacology Research20
5Erythrocyte Function and Pathophysiology11
6Pancreatic function and diabetes11
7Nitric Oxide and Endothelin Effects10
8Amino Acid Enzymes and Metabolism9
9Neuropeptides and Animal Physiology9
10Physiological and biochemical adaptations9

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Tai AkeraMichigan State University67
2Arnold SchwartzBaylor College of Medicine63
3John M. HamlynUniversity of Maryland, Baltimore48
4Erland ErdmannLMU Klinikum45
5Torben ClausenAarhus University40
6Amir AskariUniversity of Toledo Medical Center35
7David LichtsteinHebrew University of Jerusalem35
8Frans H. H. LeenenUniversity of Ottawa34
9Jerry B. LingrelUniversity of Cincinnati Medical Center31
10E. Edward BittarUniversity of Wisconsin–Madison30

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Ouabain?

Ouabain has the molecular formula C29H60O20 and a molecular weight of 728.779 g/mol. It is commonly encountered as an octahydrate form, also known by synonyms including G-Strophanthin and Ouabain octahydrate.

Which organizations hold the most patents related to Ouabain?

Bristol Myers Squibb Co leads with 174 patents, followed by Sigma Tau Industrie Farmaceutiche Riunite SpA and University of Tennessee Research Foundation, each with 30 patents. Other significant patent holders include Bioverial Corp with 25 patents and Oncternal Therapeutics Inc with 20 patents.

What are the primary research areas for Ouabain based on patent classifications?

The largest patent classification area is A61P (Medicinal preparation), with 533 patents, followed by C07D (Heterocyclic compounds) with 434 patents and A61K (Preparations for medicinal purposes) with 320 patents. These classifications indicate focus on pharmaceutical applications and organic chemical synthesis.

Who are the leading researchers publishing on Ouabain?

Tai Akera from Michigan State University leads with 67 papers, followed by Arnold Schwartz from Baylor College of Medicine with 63 papers and John M. Hamlyn from University of Maryland, Baltimore with 48 papers. Other prolific authors include Erland Erdmann and Torben Clausen with 45 and 40 papers respectively.

What scientific topics dominate the published research on Ouabain?

Ion Transport and Channel Regulation is the leading research topic with 80 papers, followed by Cardiac electrophysiology and arrhythmias and Ion channel regulation and function, each with 24 papers. Neuroscience and Neuropharmacology Research accounts for 20 papers, indicating Ouabain's significance in cardiovascular and ion transport physiology.

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