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Oligomycin A

(1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione · also: Fermentation product from Streptomyces sp. · Oligomycin A from Streptomyces diastatochromogenes

FormulaC45H74O11
Mol. weight791.076
PubChem CID52947716
InChIKeyMNULEGDCPYONBU-AWJDAWNUSA-N
SMILESCC[C@@H]\1CC[C@H]2[C@H]([C@H]([C@@H]([C@]3(O2)CC[C@@H]([C@@H](O3)C[C@@H](C)O)C)C)OC(=O)/C=C/[C@@H]([C@H]([C@@H](C(=O)[C@@H]([C@H]([C@@H](C(=O)[C@]([C@H]([C@@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
4,073Patents
84Research papers
456Patents - last 3 years
3Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Bristol Myers Squibb Co87
2University of California80
3Centre National de la Recherche Scientifique51
4University of North Carolina System46
5Kikkoman Corp45
6Cornell University36
7Institut National de la Santé et de la Recherche Médicale36
8Rutgers, The State University of New Jersey33
9Meiji Holdings Co Ltd32
10Cartesian Therapeutics Inc29

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)2,670
2A61KMedicinal preparations2,596
3C12NMicroorganisms, enzymes1,216
4G01NInvestigating / analysing materials805
5C07KPeptides781
6C07DHeterocyclic compounds646
7C12QMeasuring/testing involving enzymes432
8C12PFermentation, enzyme processes270
9Y02AClimate change adaptation236
10C12YEnzyme nomenclature (EC numbers)231

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Method for preparing oligomycin A and special for bacterial strain thereof20094
OLIGOMYCIN E1988Mitsubishi Chemical Group Corp4
OLIGOMYCIN SC COMPOUNDS AND ANTICANCER MEDICINE19972
STRAIN STREPTOMYCES AVERMITILIS PBM 0004 PRODUCING OLIGOMYCINS20001
Process for the preparation of oligomycin A1986Bayer AG1

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20165
20177
20181
20193
20207
20215
20232
20241

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1В. Н. ДаниленкоVavilov Institute of General Genetics7
2Andrey E. ShchekotikhinGause Institute of New Antibiotics Russian Academy of Medical Sciences6
3Natalia E. GrammatikovaGause Institute of New Antibiotics Russian Academy of Medical Sciences6
4José Marco‐ContellesInstituto de Química Orgánica General6
5Isabel IriepaUniversidad de Alcalá5
6Olga B. BekkerVavilov Institute of General Genetics5
7Olga A. OmelchukGause Institute of New Antibiotics Russian Academy of Medical Sciences4
8Mourad ChiouaInstituto de Química Orgánica General4
9Manuela G. LópezUniversidad Autónoma de Madrid4
10María Jesús Oset‐GasqueUniversidad Complutense de Madrid4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Oligomycin A?

Oligomycin A has the molecular formula C45H74O11 with a molecular weight of 791.076. Its canonical IUPAC name reflects a complex spirocyclic structure with multiple stereogenic centers, including nine methyl groups and four hydroxyl groups distributed across its bicyclic macrolide core.

Which organizations hold the most patents related to Oligomycin A?

Bristol Myers Squibb Co holds 87 patents related to Oligomycin A, making it the leading assignee. University of California follows with 80 patents, and Centre National de la Recherche Scientifique holds 51 patents. Other significant assignees include University of North Carolina System with 46 patents and Kikkoman Corp with 45 patents.

How has patent activity for Oligomycin A changed in recent years?

Patent activity has shown a general upward trend from 2016 through 2023. Filings grew from 147 patents in 2016 to a peak of 326 in 2023. The past three years (2022–2024) account for 656 of the total 4,073 patents, indicating sustained research interest, with 456 patents filed in the last three years.

What are the primary research topics associated with Oligomycin A in the scientific literature?

The most frequently cited papers address Oligomycin A's role in mitochondrial function and pathology, including its use as an inhibitor of oxidative phosphorylation and mitochondrial ATP synthesis. Additional research topics include drug transport and resistance mechanisms. Key papers in these areas include studies on mitochondrial dysfunction, F0F1-ATPase inhibition, and evaluation of intramitochondrial ATP levels.

Which patent classification codes are most common for Oligomycin A-related patents?

The most prevalent CPC classifications are pharmaceutical and medicinal chemistry codes: A61P (applicability to particular therapeutic needs) appears in 2,670 patents, A61K (pharmaceutical substances) in 2,596 patents, and C12N (microorganisms and enzymes) in 1,216 patents. G01N (measuring and testing) and C07K (organic chemistry of peptides) also represent significant areas of patenting activity.

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