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Nifos

diethoxyphosphoryl diethyl phosphate · also: Killex, Bladan, Fosvex, Tetron, Killax, Grisol

FormulaC8H20O7P2
Mol. weight290.1885
PubChem CID7873
InChIKeyIDCBOTIENDVCBQ-UHFFFAOYSA-N
SMILESCCOP(=O)(OCC)OP(=O)(OCC)OCC
15,991Patents
87Research papers
765Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Corteva Agriscience LLC905
2Syngenta Participations AG548
3Resonac Corp337
4Toray Industries Inc326
5Konica Minolta Inc207
6Boehringer Ingelheim Animal Health USA Inc200
7Syngenta Crop Protection AG Switzerland152
8Teijin Ltd145
9Daikin Industries Ltd131
10Tokyo Ohka Kogyo Co Ltd127

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A01NPreservation of bodies; biocides; pest repellents4,128
2C07DHeterocyclic compounds3,074
3A61PTherapeutic activity (drug indications)1,702
4A61KMedicinal preparations1,438
5C07CAcyclic and carbocyclic compounds879
6Y10TCross-reference (technical subjects)768
7Y02EClimate change mitigation: energy571
8C07FOrganometallic compounds548
9C08LPolymer compositions (blends)541
10Y02AClimate change adaptation434

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Quantum computing methods and devices for Majorana Tetron qubits2019Microsoft Technology Licensing LLC14
Process for the preparation of tetronic acid1982Lonza AG5
Oxaspirocyclical spiro-substituted tetram and tetron acid derivatives2009Bayer CropScience AG3
Process for the preparation of tetronic acid esters1991Lonza AG2
CONTINUOUS MOLDING METHOD OF TEA BAG MADE OF NYLON AND TETRON WOVEN CLOTH1985CHIYASEIZANEN:KK2

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1History and advancements in chemistry2
2Computational Drug Discovery Methods1
3Pesticide Exposure and Toxicity1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Georg PetroianuUnited Arab Emirates University4
2Alexander G. KarczmarSterling Research Group (United States)3
3F HobbigerMiddlesex Hospital3
4W. W. Douglas3
5B. P. McNamaraUnited States Army2
6Coon Jm2
7E. H. ColhounSociety for Science & the Public2
8Edmund F. MurthaUnited States Army2
9Griffith E. Quinby2
10J. H. WillsUnited States Army2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
ACETYLCHOLINESTERASE1951210Calpain Protease Function and Regulation
Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo200297Neuroscience and Neuropharmacology Research
THE ROLE OF A-ESTERASE IN THE ACUTE TOXICITY OF PARAOXON, TEPP, AND PARATHION195688Pharmacogenetics and Drug Metabolism
New Potent Reactivators of Acetocholinesterase Inhibited by Tetraethyl Pyrophosphate195887Inorganic and Organometallic Chemistry
THE REVERSIBLE INHIBITION OF ACETYLESTERASE BY DIISOPROPYL FLUOROPHOSPHATE AND TETRAETHYL PYROPHOSPHATE194867Computational Drug Discovery Methods

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Nifos?

Nifos has the molecular formula C8H20O7P2 and a molecular weight of 290.1885. The compound is also known by its canonical name diethoxyphosphoryl diethyl phosphate.

Which organizations hold the most patents related to Nifos?

Corteva Agriscience LLC holds the most patents with 905, followed by Syngenta Participations AG with 548 patents, and Resonac Corp with 337 patents.

What is the significance of Nifos in acetylcholinesterase research?

Nifos, also known as tetraethyl pyrophosphate, is notable as a cholinesterase inhibitor. A 1948 paper examined the reversible inhibition of acetylesterase by tetraethyl pyrophosphate, and a 1958 paper focused on potent reactivators of acetylcholinesterase inhibited by tetraethyl pyrophosphate, demonstrating its importance in enzyme inhibition studies.

How many patents and papers have been published related to Nifos in the last three years?

In the last three years, there were 793 patents published related to Nifos, but no papers were published during this period according to the available data.

What are the primary patent classification areas for compounds related to Nifos?

The most prevalent patent classifications are A01N (pesticides and related compounds) with 4128 patents, C07D (heterocyclic compounds) with 3074 patents, and A61P (pharmaceutical active ingredients) with 1702 patents, indicating Nifos is primarily associated with pesticide and pharmaceutical applications.

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