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Tetraethyl Pyrophosphate

diethoxyphosphoryl diethyl phosphate · also: Nifos · Killax · Bladan · Tetron · Grisol · Nifost

FormulaC8H20O7P2
Mol. weight290.1885
PubChem CID7873
InChIKeyIDCBOTIENDVCBQ-UHFFFAOYSA-N
SMILESCCOP(=O)(OCC)OP(=O)(OCC)OCC
15,991Patents
87Research papers86 indexed in detail
718Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Corteva Inc975
2Sinochem Holdings Corp Ltd803
3Resonac Holdings Corp358
4Toray Industries Inc351
5Konica Minolta Inc234
6C.H. Boehringer Sohn AG and Co KG200
7Teijin Ltd194
8Tokyo Ohka Kogyo Co Ltd171
9Novartis AG161
10Daikin Industries Ltd137

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A01NPreservation of bodies; biocides; pest repellents4,128
2C07DHeterocyclic compounds3,074
3A61PTherapeutic activity (drug indications)1,702
4A61KMedicinal preparations1,438
5C07CAcyclic and carbocyclic compounds879
6Y10TCross-reference (technical subjects)768
7Y02EClimate change mitigation: energy571
8C07FOrganometallic compounds548
9C08LPolymer compositions (blends)541
10Y02AClimate change adaptation434

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Quantum computing methods and devices for Majorana Tetron qubits2019Microsoft Corp14
Manufacture of tetraethyl pyrophosphate1955Bayer AG8
Preparation of tetraethyl pyrophosphate1952Eastman Kodak Co8
Process for the preparation of tetronic acid1982Lonza Group AG5
Method of producing tetraethyl pyrophosphate19505

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20171
20212
20221

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Georg PetroianuUnited Arab Emirates University4
2F HobbigerMiddlesex Hospital3
3Alexander G. KarczmarSterling Research Group (United States)3
4W. W. Douglas3
5Claudia Sassi2
6Griffith E. Quinby2
7Coon Jm2
8W. D. M. Paton2
9E. H. ColhounSociety for Science & the Public2
10Edmund F. MurthaUnited States Army2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
ACETYLCHOLINESTERASE1951211Calpain Protease Function and Regulation
Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo200297Neuroscience and Neuropharmacology Research
THE ROLE OF A-ESTERASE IN THE ACUTE TOXICITY OF PARAOXON, TEPP, AND PARATHION195688Pharmacogenetics and Drug Metabolism
New Potent Reactivators of Acetocholinesterase Inhibited by Tetraethyl Pyrophosphate195887Inorganic and Organometallic Chemistry
THE REVERSIBLE INHIBITION OF ACETYLESTERASE BY DIISOPROPYL FLUOROPHOSPHATE AND TETRAETHYL PYROPHOSPHATE194867Computational Drug Discovery Methods

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of tetraethyl pyrophosphate?

Tetraethyl pyrophosphate has the molecular formula C8H20O7P2 with a molecular weight of 290.1885. It is also known by its canonical name diethoxyphosphoryl diethyl phosphate.

Which companies hold the most patents related to tetraethyl pyrophosphate?

Corteva Inc leads with 975 patents, followed by Sinochem Holdings Corp Ltd with 803 patents. Other significant patent holders include Resonac Holdings Corp with 358 patents and Toray Industries Inc with 351 patents.

What are some of the commercial trade names for this compound?

Tetraethyl pyrophosphate is marketed under multiple trade names including Nifos, Killax, Bladan, Tetron, Grisol, Fosvex, Vapotone, and Hexamite, among others.

What does the patent literature reveal about the biological activity of tetraethyl pyrophosphate?

Published research indicates that tetraethyl pyrophosphate acts as an inhibitor of acetylcholinesterase. A 1948 paper titled "THE REVERSIBLE INHIBITION OF ACETYLESTERASE BY DIISOPROPYL FLUOROPHOSPHATE AND TETRAETHYL PYROPHOSPHATE" examined this inhibition, and a 1958 paper addressed "New Potent Reactivators of Acetocholinesterase Inhibited by Tetraethyl Pyrophosphate".

How has patent activity for tetraethyl pyrophosphate changed in recent years?

Patent filings related to tetraethyl pyrophosphate have declined in recent years. Annual patent counts decreased from 536 in 2018 to 385 in 2024, with only 176 patents recorded in 2025. Over the last three years, there have been 718 patents total with no papers published in the last three years.

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