Book a demo

Chemical intelligence powered by cypris.ai

Tetraethyl Pyrophosphate

diethoxyphosphoryl diethyl phosphate · also: Nifos, Killax, Bladan, Tetron, Grisol, Nifost

FormulaC8H20O7P2
Mol. weight290.1885
PubChem CID7873
InChIKeyIDCBOTIENDVCBQ-UHFFFAOYSA-N
SMILESCCOP(=O)(OCC)OP(=O)(OCC)OCC
15,991Patents
87Research papers
750Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Corteva Agriscience LLC905
2Syngenta Participations AG548
3Resonac Corp337
4Toray Industries Inc326
5Konica Minolta Inc207
6Boehringer Ingelheim Animal Health USA Inc200
7Syngenta Crop Protection AG Switzerland152
8Teijin Ltd145
9Daikin Industries Ltd131
10Tokyo Ohka Kogyo Co Ltd127

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

Visit Cypris

Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A01NPreservation of bodies; biocides; pest repellents4,128
2C07DHeterocyclic compounds3,074
3A61PTherapeutic activity (drug indications)1,702
4A61KMedicinal preparations1,438
5C07CAcyclic and carbocyclic compounds879
6Y10TCross-reference (technical subjects)768
7Y02EClimate change mitigation: energy571
8C07FOrganometallic compounds548
9C08LPolymer compositions (blends)541
10Y02AClimate change adaptation434

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

See Cypris in action

Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Quantum computing methods and devices for Majorana Tetron qubits2019Microsoft Technology Licensing LLC14
Manufacture of tetraethyl pyrophosphate1955Monsanto Chemical Co8
Preparation of tetraethyl pyrophosphate1952Eastman Kodak Co8
Process for the preparation of tetronic acid1982Lonza AG5
Method of producing tetraethyl pyrophosphate1950VICTOR CHEMICAL WORKS5

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1History and advancements in chemistry2
2Computational Drug Discovery Methods1
3Pesticide Exposure and Toxicity1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Georg PetroianuUnited Arab Emirates University4
2Alexander G. KarczmarSterling Research Group (United States)3
3F HobbigerMiddlesex Hospital3
4W. W. Douglas3
5B. P. McNamaraUnited States Army2
6Coon Jm2
7E. H. ColhounSociety for Science & the Public2
8Edmund F. MurthaUnited States Army2
9Griffith E. Quinby2
10Irwin B. WilsonColumbia University2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

See Cypris in action

The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
ACETYLCHOLINESTERASE1951211Calpain Protease Function and Regulation
Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo200297Neuroscience and Neuropharmacology Research
THE ROLE OF A-ESTERASE IN THE ACUTE TOXICITY OF PARAOXON, TEPP, AND PARATHION195688Pharmacogenetics and Drug Metabolism
New Potent Reactivators of Acetocholinesterase Inhibited by Tetraethyl Pyrophosphate195887Inorganic and Organometallic Chemistry
THE REVERSIBLE INHIBITION OF ACETYLESTERASE BY DIISOPROPYL FLUOROPHOSPHATE AND TETRAETHYL PYROPHOSPHATE194867Computational Drug Discovery Methods

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Tetraethyl Pyrophosphate?

Tetraethyl Pyrophosphate has the molecular formula C8H20O7P2 and a molecular weight of 290.1885. It is also known by its canonical name diethoxyphosphoryl diethyl phosphate.

Which companies hold the most patents related to this compound?

The leading assignees in the patent landscape are Corteva Agriscience LLC with 905 patents, Syngenta Participations AG with 548 patents, and Resonac Corp with 337 patents.

What are the key historical patents for Tetraethyl Pyrophosphate manufacture?

Early manufacturing patents include 'Manufacture of tetraethyl pyrophosphate' filed by Monsanto Chemical Co in 1955, 'Preparation of tetraethyl pyrophosphate' by Eastman Kodak Co in 1952, and 'Method of producing tetraethyl pyrophosphate' by VICTOR CHEMICAL WORKS in 1950.

What research topics are associated with Tetraethyl Pyrophosphate?

Published research on this compound spans multiple areas, including work on acetylcholinesterase inhibition, pesticide toxicity, and pharmacogenetics. Key topics include 'History and advancements in chemistry', 'Computational Drug Discovery Methods', and 'Pesticide Exposure and Toxicity'.

How has patent activity trended in recent years?

Patent filings related to compounds in this space showed activity of 750 patents in the last 3 years. The year-by-year trend shows 501 patents in 2020, 450 in 2021, 413 in 2022, 419 in 2023, and 385 in 2024, with a decline to 176 in 2025 and 28 in 2026.

Turn any compound into a complete chemical intelligence landscape

Go beyond static compound data. Cypris resolves identities, patents, papers, and commercial signals into one AI-powered view - so your team can move from a single chemical question to a complete R&D, IP, and market landscape.

Schedule a free trial