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N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide

N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide · also: N-(4-hydroxyphenyl)eicosa-5,8,11,14-tetraenamide · N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide

FormulaC26H37NO2
Mol. weight395.587
PubChem CID2127
InChIKeyIJBZOOZRAXHERC-UHFFFAOYSA-N
SMILESCCCCCC=CCC=CCC=CCC=CCCCC(=O)NC1=CC=C(C=C1)O
47Patents
194Research papers195 indexed in detail
1Patents - last 3 years
1Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1University of California13
2Sumitomo Chemical Co Ltd6
3AstraZeneca PLC1
4Capital Medical University1
5Johnson and Johnson1
6University of Illinois System1
7Vanderbilt University1

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)38
2A61KMedicinal preparations29
3C07CAcyclic and carbocyclic compounds20
4C07DHeterocyclic compounds19
5G01NInvestigating / analysing materials9
6C40B6
7C12NMicroorganisms, enzymes4
8Y02AClimate change adaptation1

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
MODULATION OF ANXIETY THROUGH BLOCKADE OF ANANDAMIDE HYDROLYSIS2004University of California57
Modulation of anxiety through blockade of anandamide hydrolysis2007University of California21
COMPOUNDS AND METHODS FOR TREATING NON-INFLAMMATORY PAIN USING PPARALPHA AGONISTS2005University of California23
CANNABINERGIC LIPID LIGANDS200616
COMPOSITIONS AND METHODS OF TREATMENT USING MODULATORS OF MOTONUERON DISEASES200713

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20162
20176
20184
20192
20202
20213
20222
20241

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Daniele PiomelliUniversity of California, Irvine20
2Alexandros MakriyannisUniversity of Connecticut15
3Vincenzo Di MarzoIstituto di Chimica Biomolecolare13
4Antonio CalignanoUniversity of Naples Federico II8
5Fernando Rodrı́guez de FonsecaUniversidad Complutense de Madrid7
6Cecilia J. HillardMedical College of Wisconsin7
7Massimiliano BeltramoNeurosciences Institute7
8Javier Fernández‐RuízUniversidad Complutense de Madrid6
9Leonardo B.M. ResstelUniversidade de São Paulo6
10Francisco Silveira GuimarãesUniversidade de São Paulo6

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide?

N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide has the molecular formula C26H37NO2 and a molecular weight of 395.587. It is also known by the alternative names N-(4-hydroxyphenyl)eicosa-5,8,11,14-tetraenamide and N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide.

Which organizations hold the most patents covering this compound?

University of California holds the largest patent portfolio with 13 patents, followed by Sumitomo Chemical Co Ltd with 6 patents. Other assignees with smaller patent counts include AstraZeneca PLC, Capital Medical University, Johnson and Johnson, University of Illinois System, and Vanderbilt University.

What are the primary research applications indicated by patent classification?

Patents covering this compound are primarily classified under A61P (38 patents) and A61K (29 patents), which relate to pharmaceutical preparations and therapeutic applications. Additional significant classifications include C07C (20 patents) and C07D (19 patents), indicating chemical synthesis and organic compound preparation.

Which researchers are most prominent in the literature on this compound?

Daniele Piomelli has authored the most papers on this compound with 20 publications, followed by Alexandros Makriyannis with 15 papers and Vincenzo Di Marzo with 13 papers. Other prolific authors include Antonio Calignano, Fernando Rodríguez de Fonseca, Cecilia J. Hillard, and Massimiliano Beltramo, each with 7 publications.

What are the most highly cited scientific works on this compound?

The most cited paper is 'Modulation of anxiety through blockade of anandamide hydrolysis' from 2002 with 1294 citations. Other highly cited works include 'Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity' (352 citations), 'Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors' (350 citations), and 'Endogenous cannabinoid signaling is essential for stress adaptation' (349 citations).

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