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Met-enkephalin

(2S)-2-[[(2R)-2-[[2-[[2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid · also: L-Methionine, L-tyrosylglycylglycyl-L-phenylalanyl-

FormulaC27H35N5O7S
Mol. weight573.665
PubChem CID6427062
InChIKeyYFGBQHOOROIVKG-BHIFYINESA-N
SMILESCSCC[C@@H](C(=O)O)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@@H](CC2=CC=C(C=C2)O)N
2,554Patents
402Research papers
90Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Purdue Pharma LP174
2Allergan Inc118
3Aventis Pharmaceuticals Inc56
4Bausch Health Ireland Ltd56
5Vertex Pharmaceuticals Inc50
6Janssen R&D Ireland ULC47
7Pharmacia LLC47
8Durect Corp46
9Japan Tobacco Inc45
10Leland Stanford Junior University43

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations1,744
2A61PTherapeutic activity (drug indications)1,731
3C07KPeptides950
4C07DHeterocyclic compounds611
5C12NMicroorganisms, enzymes393
6G01NInvestigating / analysing materials390
7C07CAcyclic and carbocyclic compounds139
8C12QMeasuring/testing involving enzymes118
9C12YEnzyme nomenclature (EC numbers)118
10Y02AClimate change adaptation98

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
USE OF MELANIN CONCENTRATING HORMONE AND MET-ENKEPHALIN AS THERAPEUTIC AGENTS2009Mondobiotech Laboratories AG4
USE OF MET-ENKEPHALIN AS A THERAPEUTIC AGENT2009Mondobiotech Laboratories AG3
Aerosol contg. met-enkephalin2006DAN FENGPING2
USE OF MET-ENKEPHALIN AS A THERAPEUTIC AGENT2009Mondobiotech Laboratories AG0
USE OF MELANIN CONCENTRATING HORMONE AND MET-ENKEPHALIN AS THERAPEUTIC AGENTS2009Mondobiotech Laboratories AG0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Neuropeptides and Animal Physiology3
2Pain Mechanisms and Treatments2
3Anesthesia and Sedative Agents1
4Circadian rhythm and melatonin1
5Drug Transport and Resistance Mechanisms1
6Hormonal Regulation and Hypertension1
7Lipid Membrane Structure and Behavior1
8Neurological disorders and treatments1
9Parasite Biology and Host Interactions1
10Prostate Cancer Treatment and Research1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Bahram Sayyaf DezfuliUniversity of Ferrara9
2Christoph SteinCharité - Universitätsmedizin Berlin7
3Luisa GiariUniversity of Ferrara6
4Alexander BrackUniversity of Würzburg4
5Bernd A. BergFlorida State University4
6Christopher W. VaughanThe University of Sydney4
7David C. YeomansStanford University4
8Dominika ŁabuzFranklin University4
9Edi SimoniUniversity of Ferrara4
10George B. StefanoSUNY Old Westbury4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Met-enkephalin?

Met-enkephalin has the molecular formula C27H35N5O7S and a molecular weight of 573.665. Its canonical name is (2S)-2-[[(2R)-2-[[2-[[2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid, and it is also known by the synonym L-Methionine, L-tyrosylglycylglycyl-L-phenylalanyl-.

How extensive is the patent portfolio for Met-enkephalin?

Met-enkephalin has a total of 2554 patents on record. In the last 3 years, 90 new patents have been filed. The leading patent assignee is Purdue Pharma LP with 174 patents, followed by Allergan Inc with 118 patents and Aventis Pharmaceuticals Inc with 56 patents.

What are the primary patent classification areas for Met-enkephalin?

Met-enkephalin patents are concentrated in pharmaceutical and chemical synthesis areas. The most common CPC subclass is A61K (medicinal preparations) with 1744 patents, followed closely by A61P (therapeutic and prophylactic compounds) with 1731 patents. Peptide synthesis and modification patents under C07K account for 950 patents.

Which researchers have published the most on Met-enkephalin?

The most prolific author on Met-enkephalin research is Bahram Sayyaf Dezfuli from the University of Ferrara with 9 papers. Christoph Stein from Charité - Universitätsmedizin Berlin follows with 7 papers, and Luisa Giari, also from the University of Ferrara, has published 6 papers on the subject.

What research topics are associated with Met-enkephalin in the academic literature?

The primary research topic associated with Met-enkephalin is Neuropeptides and Animal Physiology, appearing in 3 papers. Pain Mechanisms and Treatments is the second most common topic with 2 papers. Notable highly-cited papers include Structure of Met-enkephalin in explicit aqueous solution using replica exchange molecular dynamics (283 citations), and research on Nucleus Accumbens μ-Opioid Receptors Mediate Social Reward (270 citations).

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