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Bacitracin methylenedisalicylic acid

(4R)-5-[[(2S,3S)-1-[[(2S)-6-amino-1-[[(2R)-5-amino-1-[[(2S,3S)-1-[[(2R)-1-[[(2S)-1-[[(2R)-1-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoic acid;(2-hydroxybenzoyl)oxymethyl 2-hydroxybenzoate · also: bacitracin MD · MD bacitracin · Caswell No. 066D · Fortracin (bacitracin-MD) · Methylenebis(2-hydroxybenzoate)bacitracin

FormulaC81H117N17O23S
Mol. weight1728.983
PubChem CID11980094
InChIKeyPOMORUSPLDFVEK-PHXAWWDYSA-N
SMILESCC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)C3CSC(=N3)C(C(C)CC)N.C1=CC=C(C(=C1)C(=O)OCOC(=O)C2=CC=CC=C2O)O
819Patents
46Research papers
104Patents - last 3 years
5Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Medtronic PLC75
2Corteva Inc31
3Massachusetts Institute of Technology22
4Pfizer Inc22
5University of Nebraska System17
6The University of Texas System15
7Mitsui & Co Ltd14
8Mass General Brigham Inc13
9Government of the United States of America12
10Boston Children's Hospital11

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations560
2A61PTherapeutic activity (drug indications)433
3A23KAnimal feeds189
4C12NMicroorganisms, enzymes177
5Y02AClimate change adaptation122
6C07KPeptides112
7A61B50
8C12R46
9A61F44
10A61LSterilising / disinfecting materials41

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssignee
Preparation method of suspension containing bacitracin methylenedisalicylic acid and robenidine2015

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20161
20174
20184
20194
20203
20244
20251

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1M.D. SimsGraf Research (United States)5
2P.W. WaldroupUniversity of Arkansas at Fayetteville3
3Hyun S. LillehojBeltsville Agricultural Research Center3
4RALPH V. FELL3
5Greg F. MathisU.S. National Poultry Research Center3
6Yewande O. FasinaNorth Carolina Agricultural and Technical State University2
7R.A. PRIMORocky Mountain Research (United States)2
8Michael C. BrummConcordia University2
9Wilmer J. PachecoAuburn University2
10W.A. DozierAuburn University2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Bacitracin methylenedisalicylic acid?

Bacitracin methylenedisalicylic acid has the molecular formula C81H117N17O23S with a molecular weight of 1728.983. Its InChI Key is POMORUSPLDFVEK-PHXAWWDYSA-N.

Which organizations hold the most patents related to this compound?

The leading patent assignees are Medtronic PLC with 75 patents, Corteva Inc with 31 patents, Massachusetts Institute of Technology with 22 patents, and Pfizer Inc with 22 patents.

What are the primary research topics in published papers on this compound?

Published papers on this compound focus on Animal Nutrition and Physiology. Notable papers examine effects on live performance and intestinal microbiology of poultry, intestinal immune status in broiler chickens, and interactions with feed additives and pathogenic infections.

How has patent activity for this compound changed in recent years?

Patent filings show an increasing trend, with 53 patents filed in 2024 and 39 in 2025, compared to 20-24 annually from 2016 to 2020. The last 3 years account for 104 of the total 819 patents.

What patent classification areas dominate the intellectual property landscape for this compound?

Patent classifications show concentration in A61K (560 patents), A61P (433 patents), and A23K (189 patents), indicating focus on pharmaceuticals, medical applications, and animal feed sectors. Biotechnology-related classifications C12N and C07K account for 177 and 112 patents respectively.

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