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Bacitracin methylenedisalicylic acid

(4R)-5-[[(2S,3S)-1-[[(2S)-6-amino-1-[[(2R)-5-amino-1-[[(2S,3S)-1-[[(2R)-1-[[(2S)-1-[[(2R)-1-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoic acid;(2-hydroxybenzoyl)oxymethyl 2-hydroxybenzoate · also: bacitracin MD, MD bacitracin, Caswell No. 066D, Fortracin (bacitracin-MD), Methylenebis(2-hydroxybenzoate)bacitracin, Bacitracin, methylenebis(2-hydroxybenzoate)

FormulaC81H117N17O23S
Mol. weight1728.983
PubChem CID11980094
InChIKeyPOMORUSPLDFVEK-PHXAWWDYSA-N
SMILESCC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)C3CSC(=N3)C(C(C)CC)N.C1=CC=C(C(=C1)C(=O)OCOC(=O)C2=CC=CC=C2O)O
819Patents
46Research papers
108Patents - last 3 years
5Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Warsaw Orthopedic Inc75
2EIDP Inc22
3Massachusetts Institute of Technology22
4University of Nebraska System17
5The University of Texas System15
6Novus International Inc12
7Boston Children's Hospital11
8Alnylam Pharmaceuticals Inc9
9Pioneer Hi-Bred International Inc9
10Coley Pharmaceutical GmbH8

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations560
2A61PTherapeutic activity (drug indications)431
3A23KAnimal feeds189
4C12NMicroorganisms, enzymes177
5Y02AClimate change adaptation122
6C07KPeptides112
7A61B50
8C12R46
9A61F44
10A61LSterilising / disinfecting materials41

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Preparation method of suspension containing bacitracin methylenedisalicylic acid and robenidine2015QINGDAO CONLINENT ANIMAL PHARMACEUTICAL CO., LTD.0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Animal Nutrition and Physiology2

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1M.D. SimsGraf Research (United States)5
2P.W. WaldroupUniversity of Arkansas at Fayetteville4
3Greg F. MathisU.S. National Poultry Research Center3
4Hyun S. LillehojBeltsville Agricultural Research Center3
5RALPH V. FELL3
6B.L. DamronUniversity of Florida2
7Brett Lumpkins2
8H. HellwigUniversity of Arkansas at Fayetteville2
9J. R. HernándezAuburn University2
10J.I. VargasAuburn University2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Effects of Dietary Mannan Oligosaccharide, Bacitracin Methylene Disalicylate, or Both on the Live Performance and Intestinal Microbiology of Turkeys2004204Animal Nutrition and Physiology
Effects of a Buffered Propionic Acid in Diets on the Performance of Broiler Chickens and on Microflora of the Intestine and Carcass1990144Animal Nutrition and Physiology
The Effects of Direct-fed Microbial Supplementation, as an Alternative to Antibiotics, on Growth Performance, Intestinal Immune Status, and Epithelial Barrier Gene Expression in Broiler Chickens2017115Animal Nutrition and Physiology
Beneficial Effect of β-Mannanase Feed Enzyme on Performance of Chicks Challenged with Eimeria sp. and Clostridium perfringens200396Animal Nutrition and Physiology
Effects of Feed Additives and Mixed Eimeria Species Infection on Intestinal Microbial Ecology of Broilers200693Animal Nutrition and Physiology

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Bacitracin methylenedisalicylic acid?

Bacitracin methylenedisalicylic acid has a molecular formula of C81H117N17O23S and a molecular weight of 1728.983 g/mol.

Which assignees hold the most patents related to Bacitracin methylenedisalicylic acid?

Warsaw Orthopedic Inc leads with 75 patents, followed by EIDP Inc and Massachusetts Institute of Technology, each with 22 patents, and University of Nebraska System with 17 patents.

What are the primary patent classification codes associated with this compound?

The compound is most heavily classified under A61K (560 patents), A61P (431 patents), and A23K (189 patents), indicating applications in pharmaceuticals, medical treatments, and animal feed additives.

What research topics are covered in the scientific literature on this compound?

The published papers on Bacitracin methylenedisalicylic acid focus on Animal Nutrition and Physiology, with studies examining its effects on poultry performance, intestinal microbiology, and use as an alternative to antibiotics in animal feed.

What was the recent patenting trend for this compound?

Patent activity for Bacitracin methylenedisalicylic acid increased significantly in recent years, with 53 patents filed in 2024 and 39 in 2025, compared to 20 in 2016. In the last 3 years, 108 patents have been filed out of 819 total.

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