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Lasmiditan HCl

2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridinyl]benzamide;hydrochloride · also: COL-144 hydrochloride · LY-573144 Hydrochloride · Lasmiditan hydrochloride · Lasmiditan (hydrochloride) · 2,4,6-Trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide hydrochloride

FormulaC19H19ClF3N3O2
Mol. weight413.8252
PubChem CID17980336
InChIKeyYBTPRLDGGGYWIP-UHFFFAOYSA-N
SMILESCN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.Cl
67Patents
112Research papers114 indexed in detail
17Patents - last 3 years
23Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Eli Lilly and Co37

Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)65
2A61KMedicinal preparations46
3C07DHeterocyclic compounds41
4C07BGeneral methods of organic chemistry21
5Y02PClimate change mitigation: production15
6C07CAcyclic and carbocyclic compounds14
7C07KPeptides10
8Y02EClimate change mitigation: energy3

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
COMPOSITIONS AND METHODS OF SYNTHESIS OF PYRIDINOYLPIPERIDINE 5-HT1F AGONISTS2011Eli Lilly and Co56
COMBINATION THERAPY OF LASMIDITAN AND A CGRP ANTAGONIST FOR USE IN THE TREATMENT OF MIGRAINE2019Eli Lilly and Co13
Pyridinoylpiperidines as 5-HT1F agonists2008Eli Lilly and Co22
A kind of preparation method of 5-HT1F agonist compound20195
Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists2014Eli Lilly and Co7

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20174
20182
201917
202025
202124
202213
202311
202411
20251

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1John H. KregeEli Lilly (United States)18
2Mika KomoriEli Lilly (Japan)11
3Erin DotyEli Lilly (United States)10
4Simin BayganiEli Lilly (United States)8
5Rashna KhannaEli Lilly (United Kingdom)6
6Ellen B. DennehyPurdue University West Lafayette6
7Helen HochstetlerEli Lilly (United States)5
8Louise LombardEli Lilly (United States)5
9Joel RaskinEli Lilly (United States)5
10Li Shen LooEli Lilly (United States)5

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Lasmiditan HCl?

Lasmiditan HCl has the molecular formula C19H19ClF3N3O2 and a molecular weight of 413.8252.

Who is the primary patent assignee for Lasmiditan, and how many patents do they hold?

Eli Lilly and Co is the primary assignee, holding 37 patents related to Lasmiditan HCl.

What therapeutic indication is Lasmiditan HCl primarily studied for?

Lasmiditan HCl is primarily studied for the acute treatment of migraine. This is reflected in the major publications on the compound, including Phase 3 randomized, placebo-controlled studies, and papers establishing its efficacy as a 5-HT1F receptor agonist for migraine treatment.

Which author has published the most papers on Lasmiditan HCl?

John H. Krege from Eli Lilly (United States) has published the most papers on Lasmiditan HCl, with 18 papers.

What is the dominant patent classification for Lasmiditan-related intellectual property?

The dominant patent classification is A61P (Specific therapeutic activity of chemical compounds or medicinal preparations), which appears in 65 patents. This is followed by A61K (Preparations for medical, dental, or toilet purposes) with 46 patents and C07D (Heterocyclic compounds) with 41 patents.

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