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Largon

1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydrochloride · also: hydrochloride, Propiomazine HCl, Propiomazinhydrochlorid, Propiomazine hydrochloride, propiomazine hydrochloride

FormulaC20H25ClN2OS
Mol. weight376.943
PubChem CID71802
InChIKeyUGVNGSMLNPWNNA-UHFFFAOYSA-N
SMILESCCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C.Cl
87Patents
33Research papers
0Patents - last 3 years
1Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Zalicus Inc30
2Fred Hutchinson Cancer Center19
3Follica Inc8
4Penwest Pharmaceuticals Co7
5Angiotech International AG5
6Puretech Ventures LLC4
7University of Pennsylvania3
8Organon Pharma UK Ltd2
9Agilent Technologies Inc1
10Bayer Oy1

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations61
2A61PTherapeutic activity (drug indications)46
3A01NPreservation of bodies; biocides; pest repellents17
4C12NMicroorganisms, enzymes14
5A61MDevices for introducing media into the body11
6Y02AClimate change adaptation7
7A61B6
8A61QCosmetics, personal care6
9A61F5
10A61LSterilising / disinfecting materials5

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1A PosnerHarlem Hospital Center1
2A S RIVERO1
3ANDRES I. REYESMaimonides Medical Center1
4Abdelwahab AhmedMcGill University1
5Adam J. KrakowskiChamplain Valley Physicians Hospital1
6Albert ElmsjöSwedish National Board of Forensic Medicine1
7Anna AxmonLund University1
8Anna NordströmUmeå University1
9Birgitta JonassonUppsala University1
10Bradley E. SmithSt Albans City Hospital1

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Largon?

Largon has the molecular formula C20H25ClN2OS and a molecular weight of 376.943. It is also known by the canonical name 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydrochloride.

Which organizations hold the most patents involving Largon?

Zalicus Inc holds the highest number of patents at 30, followed by Fred Hutchinson Cancer Center with 19 patents. Other significant patent holders include Follica Inc with 8 patents and Penwest Pharmaceuticals Co with 7 patents.

What are the main patent classification areas for Largon-related inventions?

The primary patent classifications are A61K (61 patents), A61P (46 patents), and A01N (17 patents). Additional classifications include C12N (14 patents) and A61M (11 patents), covering pharmaceutical, therapeutic, and biological applications.

What historical research has been published on Largon's clinical applications?

Early publications examined Propiomazine Hydrochloride's use in obstetrical analgesia and maternal-fetal effects, both published in 1962. More recent work from 2019 evaluated the risk of fracture associated with hypnotic medications. A 2017 register study addressed potentially inappropriate medication prescriptions in older people with intellectual disability.

How has research activity on Largon changed in recent years?

Patent activity has been minimal in recent years, with only 4 patents granted between 2016 and 2021. Paper publication activity is also limited, with only 1 paper published in the last 3 years (as of the data provided). Historical patent and paper counts total 87 patents and 33 papers respectively.

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