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Isofraxidin

7-hydroxy-6,8-dimethoxychromen-2-one · also: Phytodolor · iso-Fraxidin · Isofraxidin (Standard) · 6,8-Dimethoxyumbelliferone · 6,8-dimethoxy-7-hydroxycoumarin · 7-Hydroxy-6,8-dimethoxycoumarin

FormulaC11H10O5
Mol. weight222.196
PubChem CID5318565
InChIKeyHOEVRHHMDJKUMZ-UHFFFAOYSA-N
SMILESCOC1=C(C(=C2C(=C1)C=CC(=O)O2)OC)O
399Patents
64Research papers66 indexed in detail
30Patents - last 3 years
7Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Chinese Academy of Sciences2
2Institute of Chinese Materia Medica of China Academy of Chinese Medical Sciences2
3Anhui Medical University1
4CapitalBio Corp1
5Excrx Singapore Pte Ltd1
6Lion Corp1
7State Grid Corp of China1
8University of Pennsylvania1

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations112
2A61PTherapeutic activity (drug indications)53
3G01NInvestigating / analysing materials51
4Y02AClimate change adaptation41
5A23LFoods and beverages (general)25
6A61QCosmetics, personal care20
7A23VFoods, foodstuffs - indexing scheme14
8A01G10
9A01NPreservation of bodies; biocides; pest repellents10
10C07DHeterocyclic compounds10

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Endophytic fungi capable of improving content of isofraxidin in Radix Acanthopanacis Semticosi through fermenting Radix Acanthopanacis Semticosi20126
Technology for synchronously extracting isofraxidin and flavonoids compounds from sarcandra glabra and applications thereof20105
One kind prepares isofraxidin method from Chinese medicinal material of sarcandra glaber20172
Method for extracting isofraxidin20112
Isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing isofraxidin crystalline compound20121

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20165
20173
20184
20192
20204
20211
20221
20233
20244

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Kaishun BiShenyang Pharmaceutical University6
2Xijun WangHeilongjiang University of Chinese Medicine5
3Haitao LvHeilongjiang University of Chinese Medicine5
4Taisuke YamazakiKohno Clinical Medicine Research Institute4
5Weifeng LiXi'an Jiaotong University4
6Yanmei ZhangHeilongjiang University of Chinese Medicine4
7Hongxin CaoChina Academy of Chinese Medical Sciences4
8Zhide HuLanzhou University3
9Hui SunShenyang Pharmaceutical University3
10Xiaofeng NiuXi'an Jiaotong University3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular structure and chemical formula of Isofraxidin?

Isofraxidin has the canonical chemical name 7-hydroxy-6,8-dimethoxychromen-2-one with the molecular formula C11H10O5 and a molecular weight of 222.196. It is also known by several synonyms including 6,8-dimethoxyumbelliferone and 6,8-dimethoxy-7-hydroxycoumarin, reflecting its coumarin structure.

Which organizations hold patents for Isofraxidin applications?

Patent assignees for Isofraxidin include Chinese Academy of Sciences, Institute of Chinese Materia Medica of China Academy of Chinese Medical Sciences, Anhui Medical University, CapitalBio Corp, Excrx Singapore Pte Ltd, Lion Corp, State Grid Corp of China, and University of Pennsylvania. The Chinese Academy of Sciences and the Institute of Chinese Materia Medica of China Academy of Chinese Medical Sciences each hold 2 patents, while the others hold 1 patent each.

What are the main research topics associated with Isofraxidin in published literature?

Published research on Isofraxidin covers several key topics including natural product bioactivities and synthesis, drug transport and resistance mechanisms, and genomics with emphasis on phytochemicals and oxidative stress. Studies document its anti-inflammatory effects, inhibition of matrix metalloproteinase expression, and reactive oxygen species scavenging properties.

Who are the most prolific authors publishing research on Isofraxidin?

The leading researchers in Isofraxidin publications are Kaishun Bi from Shenyang Pharmaceutical University with 6 papers, followed by Xijun Wang, Haitao Lv, and Yanmei Zhang from Heilongjiang University of Chinese Medicine, each with 5 papers. Other active authors include Taisuke Yamazaki, Weifeng Li, and Hongxin Cao, each with 4 papers.

What is the current patent activity trend for Isofraxidin?

Patent activity for Isofraxidin shows variable trends over recent years. Peak filing occurred in 2017 with 34 patents. Recent three-year activity (2023-2025) includes 19 patents in 2023, 17 in 2024, and 11 in 2025. The dominant patent classification is A61K (pharmaceuticals) with 112 patents, followed by A61P (specific therapeutic activity) with 53 patents, and G01N (measuring/testing) with 51 patents.

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