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Intermedine

[(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate · also: Intermedin · Intermedina · Melantropin · Intermedinum · Melanotropin · (+)-Intermedine

FormulaC15H25NO5
Mol. weight299.367
PubChem CID114843
InChIKeySFVVQRJOGUKCEG-OPQSFPLASA-N
SMILESC[C@H]([C@@](C(C)C)(C(=O)OCC1=CCN2[C@H]1[C@@H](CC2)O)O)O
5,144Patents
106Research papers
297Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Alnylam Pharmaceuticals Inc571
2Moderna Inc217
3Johnson and Johnson117
4AstraZeneca PLC112
5Arbutus Biopharma Corp77
6Novartis AG71
7Sanofi SA71
8Harvard University63
9Siemens AG63
10Bayer AG59

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations3,442
2A61PTherapeutic activity (drug indications)3,153
3C12NMicroorganisms, enzymes1,829
4C07KPeptides1,582
5C07DHeterocyclic compounds626
6G01NInvestigating / analysing materials609
7C07HSugars and derivatives419
8C12YEnzyme nomenclature (EC numbers)396
9Y02AClimate change adaptation359
10A61QCosmetics, personal care301

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Intermedin analogue prepared by bonding ring core sequence with biotin or cell-penetrating peptides201255
THERAPEUTIC USES OF INTERMEDIN 47 AND 53 PEPTIDES2009Relief Therapeutics Holding SA6
Therapeutic use of intermedin 47 peptide and intermedin 53 peptide20100
THERAPEUTIC USES OF INTERMEDIN 47 AND 53 PEPTIDES2009Relief Therapeutics Holding SA0
USE OF INTERMEDIN 47 PEPTIDE AS A THERAPEUTIC AGENT2009Relief Therapeutics Holding SA0

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20191
20211
20221

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Hiroshi KawauchiKitasato University7
2Akiyoshi TakahashiKitasato University7
3Ludger WitteTechnische Universität Braunschweig4
4Tatjana HaitinaUppsala University4
5Stephen O’RahillyUniversity of Cambridge4
6Liga ZvejnieceUniversity of Latvia4
7Ruta MucenieceUniversity of Latvia4
8Robert M. DoresUniversity of Denver4
9Maija DambrovaLatvijas Organiskās Sintēzes Institūts4
10Victor J. HrubyUniversity of Arizona4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Intermedine?

Intermedine has the molecular formula C15H25NO5 with a molecular weight of 299.367. Its canonical IUPAC name is [(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate, and it is also known by several synonyms including Intermedin, Melanotropin, and alpha-Melanotropin.

Which organizations hold the most patents related to Intermedine?

The leading patent assignees for Intermedine-related technology are Alnylam Pharmaceuticals Inc with 571 patents, Moderna Inc with 217 patents, Johnson and Johnson with 117 patents, and AstraZeneca PLC with 112 patents.

What therapeutic applications have been patented for Intermedine peptides?

Patents describe therapeutic uses of Intermedin 47 and 53 peptides, including a patent titled 'THERAPEUTIC USES OF INTERMEDIN 47 AND 53 PEPTIDES' assigned to Relief Therapeutics Holding SA, and another covering 'USE OF INTERMEDIN 47 PEPTIDE AS A THERAPEUTIC AGENT'. Additionally, patents describe Intermedin analogues prepared by bonding ring core sequences with biotin or cell-penetrating peptides.

What research topics are most represented in scientific publications about Intermedine?

The primary research focus areas identified in publications are the regulation of appetite and obesity, including studies on pro-opiomelanocortin (POMC) variants and their role in energy balance control, as well as melanocortin-4 receptor gene mutations. Additionally, epigenetics and DNA methylation studies related to the POMC gene have been published.

How has patent activity for Intermedine changed in recent years?

Patent filings related to Intermedine have shown variable activity over the past decade. The year 2023 saw the highest recent filing volume with 214 patents, followed by 2024 with 185 patents. The previous three years (2021-2023) averaged approximately 193 patents per year. As of 2025, only 56 patents had been filed through the available data period.

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