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Hydromethylthionine Mesylate

methanesulfonic acid;3-N,3-N,7-N,7-N-tetramethyl-10H-phenothiazine-3,7-diamine · also: TRX-0237 dim · Trx0237 (lmtx) · TRX0237 dimesylate · TRX-0237 dimesylate · TRx0237 (LMTX) mesylate · Leucomethylene blue Mesylate

FormulaC18H27N3O6S3
Mol. weight477.609
PubChem CID60150609
InChIKeySPCMQFLNOVTUBM-UHFFFAOYSA-N
SMILESCN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O
272Patents
39Research papers
159Patents - last 3 years
4Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1AC Immune SA25
2Roche Holding AG22
3Washington University in St. Louis14
4University of Washington9
5Sanofi SA7
6Denali Therapeutics Inc5
7Tenaya Therapeutics Inc5
8University of California5
9Genting Bhd4
10Alnylam Pharmaceuticals Inc3

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)186
2A61KMedicinal preparations178
3C07KPeptides73
4G01NInvestigating / analysing materials68
5C07DHeterocyclic compounds51
6A61B29
7C12NMicroorganisms, enzymes26
8A23LFoods and beverages (general)21
9G16HDigital health, healthcare informatics21
10G06N17

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE201249
Phenothiazine diaminium salts and their use201627
Antibody-drug conjugates comprising anti-B7-H3 antibodies20235
ANTI-TAU MTBR ANTIBODIES AND METHODS TO DETECT CLEAVED FRAGMENTS OF TAU AND USES THEREOF2024Washington University in St. Louis3
Administration and dosage of diaminophenothiazines20232

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20161
20172
20181
20194
20203
20213
20223
20232
20242

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Charles R. HarringtonUniversity of Aberdeen14
2Claude M. WischikUniversity of Aberdeen13
3Gernot RiedelUniversity of Aberdeen10
4John M. D. StoreyUniversity of Aberdeen6
5Peter BenthamTauRx (United Kingdom)5
6B. SchelterUniversity of Aberdeen5
7Serge GauthierDouglas Mental Health University Institute4
8Karin A. Kook4
9Franz TheuringCharité - Universitätsmedizin Berlin4
10Karima SchwabCharité - Universitätsmedizin Berlin4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Hydromethylthionine Mesylate?

Hydromethylthionine Mesylate has the molecular formula C18H27N3O6S3 and a molecular weight of 477.609 g/mol. Its canonical chemical name is methanesulfonic acid;3-N,3-N,7-N,7-N-tetramethyl-10H-phenothiazine-3,7-diamine.

Which organizations hold the most patents related to Hydromethylthionine Mesylate?

The leading patent assignees are AC Immune SA with 25 patents, followed by Roche Holding AG with 22 patents, and Washington University in St. Louis with 14 patents. Other significant assignees include University of Washington with 9 patents and Sanofi SA with 7 patents.

What is the current research activity trend for this compound?

Patent activity has increased substantially, with 159 patents filed in the last 3 years. The peak years were 2023 and 2024, each with 79 patents. Paper publication has been more modest, with 4 papers in the last 3 years out of 39 total papers in the database.

Who are the most prolific authors publishing research on Hydromethylthionine Mesylate?

The leading authors are Charles R. Harrington and Claude M. Wischik, both from University of Aberdeen, with 14 and 13 papers respectively. Gernot Riedel from University of Aberdeen has contributed 10 papers. Other significant contributors include John M. D. Storey from University of Aberdeen with 6 papers and Peter Bentham from TauRx (United Kingdom) with 5 papers.

What are the primary patent classification areas for inventions related to Hydromethylthionine Mesylate?

The dominant patent classifications are A61P (pharmaceutical preparations) with 186 patents and A61K (medicinal preparations) with 178 patents. Other significant areas include C07K (peptide chemistry) with 73 patents, G01N (diagnostic instruments) with 68 patents, and C07D (heterocyclic compounds) with 51 patents.

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