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Hydromethylthionine Mesylate

methanesulfonic acid;3-N,3-N,7-N,7-N-tetramethyl-10H-phenothiazine-3,7-diamine · also: Trx0237 (lmtx), TRX0237 dimesylate, TRX-0237 dimesylate, TRx0237 (LMTX) mesylate, Leucomethylene blue Mesylate, Leucomethylene blue (Mesylate)

FormulaC18H27N3O6S3
Mol. weight477.609
PubChem CID60150609
InChIKeySPCMQFLNOVTUBM-UHFFFAOYSA-N
SMILESCN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O
272Patents
39Research papers
168Patents - last 3 years
4Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1AC Immune SA25
2Genentech Inc22
3Washington University in St. Louis14
4University of Washington9
5Denali Therapeutics Inc5
6Tenaya Therapeutics Inc5
7University of California, San Diego5
8Genting Taurx Diagnostic Centre Sdn Bhd4
9Genzyme Corp4
10University of California Berkeley4

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)186
2A61KMedicinal preparations178
3C07KPeptides73
4G01NInvestigating / analysing materials68
5C07DHeterocyclic compounds51
6A61B29
7C12NMicroorganisms, enzymes26
8A23LFoods and beverages (general)21
9G16HDigital health, healthcare informatics21
10G06N17

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Claude M. WischikUniversity of Aberdeen15
2Charles R. HarringtonUniversity of Aberdeen14
3Gernot RiedelUniversity of Aberdeen10
4John M. D. StoreyUniversity of Aberdeen6
5B. SchelterUniversity of Aberdeen5
6Peter BenthamTauRx (United Kingdom)5
7Diego MontiInstitute of Molecular Science and Technologies2
8Franz TheuringCharité - Universitätsmedizin Berlin4
9Helen ShiellsTauRx (United Kingdom)4
10Karima SchwabCharité - Universitätsmedizin Berlin4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Hydromethylthionine Mesylate?

Hydromethylthionine Mesylate has the molecular formula C18H27N3O6S3 and a molecular weight of 477.609. Its canonical chemical name is methanesulfonic acid;3-N,3-N,7-N,7-N-tetramethyl-10H-phenothiazine-3,7-diamine, with InChI Key SPCMQFLNOVTUBM-UHFFFAOYSA-N.

Which organizations hold the most patents for this compound?

AC Immune SA leads with 25 patents, followed by Genentech Inc with 22 patents, and Washington University in St. Louis with 14 patents. Other significant patent holders include University of Washington with 9 patents, and Denali Therapeutics Inc, Tenaya Therapeutics Inc, and University of California, San Diego each with 5 patents.

What are the primary research areas covered by patents for Hydromethylthionine Mesylate?

The top CPC subclasses indicate focus on pharmaceutical preparations and medical uses (A61P with 186 patents, A61K with 178 patents), peptide chemistry (C07K with 73 patents), diagnostic analysis (G01N with 68 patents), and organic chemistry (C07D with 51 patents).

Who are the leading researchers publishing on this compound?

Claude M. Wischik from University of Aberdeen leads with 15 papers, followed by Charles R. Harrington also from University of Aberdeen with 14 papers, and Gernot Riedel from University of Aberdeen with 10 papers. John M. D. Storey from University of Aberdeen has 6 papers, while Peter Bentham from TauRx (United Kingdom) has 5 papers.

What is the recent patent and publication activity for this compound?

Patent activity has increased significantly in recent years, with 79 patents filed in both 2023 and 2024, compared to 45 in 2022. In the last three years, there were 168 patents and 4 papers on this compound. Publication activity remains more modest, with only 2 papers published in 2024 and 2 in 2023.

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