Book a demo

Chemical intelligence powered by cypris.ai

Guanidine thiocyanate

(diaminomethylideneamino) thiocyanate · also: Guanidino thiocyanate, Guanidinium rhodanide, Guanidinium thiocyanate, guanidine monothiocyanate, Guanidine Hydrothiocyanate

FormulaC2H4N4S
Mol. weight116.142
PubChem CID547739
InChIKeyFZPKSSRLAIBRQA-UHFFFAOYSA-N
SMILESC(#N)SN=C(N)N
11,316Patents
237Research papers
926Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1BASF Plant Science GmbH358
2Kyowa Kirin Co Ltd146
3Dana Farber Cancer Institute Inc142
4F Hoffmann La Roche AG115
5BASF SE109
6Chugai Pharmaceutical Co Ltd97
7Qiagen GmbH96
8Takeda Pharmaceutical Co Ltd93
9Exact Sciences Corp92
10Janssen Biotech Inc82

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

Visit Cypris

Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes4,983
2C07KPeptides3,953
3C12QMeasuring/testing involving enzymes3,855
4A61KMedicinal preparations3,100
5G01NInvestigating / analysing materials2,302
6A61PTherapeutic activity (drug indications)2,286
7B01L695
8Y02AClimate change adaptation570
9C12YEnzyme nomenclature (EC numbers)528
10C12PFermentation, enzyme processes500

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

See Cypris in action

Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Extraction of DNA by boiling cells in an alkaline phenol/guanidine thiocyanate solution1999Mayo Clinic in Florida41
Hybridization buffer containing guanidine thiocyanate2018Abbott Molecular Inc6
HYBRIDIZATION BUFFERS COMPRISING GUANIDINIUM THIOCYANATE2017Abbott Molecular Inc2
Preparation method of guanidine thiocyanate2021SUZHOU YACOO SCIENCE Co.,Ltd.1
Production method of guanidinium thiocyanate2013WU JIAWANG1

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Amino Acid Enzymes and Metabolism1
2Bone and Dental Protein Studies1
3Glaucoma and retinal disorders1
4MicroRNA in disease regulation1
5Molecular Biology Techniques and Applications1
6Neuroscience and Neuropharmacology Research1
7Pulmonary Hypertension Research and Treatments1
8Renal and related cancers1
9Wildlife Ecology and Conservation1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

See Cypris in action

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Alasdair J. EdgarKing's College London6
2Brigitte Berger‐BächiUniversity of Zurich5
3Claudia MiccoloFondazione IRCCS Istituto Neurologico Carlo Besta2
4Jui‐Yoa ChangThe University of Texas at Austin3
5Alfredo FuscoUniversity of Naples Federico II2
6Amane MakinoTohoku University2
7André RosenthalSignature Research (United States)2
8Ashfaque A. MemonAarhus University Hospital2
9Benno MannAugusta-Kranken-Anstalt2
10Bernd HinzmannSignature Research (United States)2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

See Cypris in action

The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of guanidine thiocyanate?

Guanidine thiocyanate has the molecular formula C2H4N4S with a molecular weight of 116.142. It is also known by the canonical name (diaminomethylideneamino) thiocyanate and has several synonyms including guanidinium thiocyanate and guanidine hydrothiocyanate.

Which organizations hold the most patents involving guanidine thiocyanate?

The leading patent assignees are BASF Plant Science GmbH with 358 patents, Kyowa Kirin Co Ltd with 146 patents, Dana Farber Cancer Institute Inc with 142 patents, F Hoffmann La Roche AG with 115 patents, and BASF SE with 109 patents.

What are the main patent classification areas for guanidine thiocyanate applications?

Patent applications involving guanidine thiocyanate are predominantly classified under C12N (4983 patents), C07K (3953 patents), C12Q (3855 patents), A61K (3100 patents), and G01N (2302 patents), indicating concentration in biotechnology, molecular biology, and diagnostic testing.

What is a notable application of guanidine thiocyanate documented in patent literature?

One significant application is extraction of DNA by boiling cells in an alkaline phenol/guanidine thiocyanate solution, as documented in a 1999 patent, which has received 41 citations. Additionally, guanidine thiocyanate has been used in hybridization buffers, as shown in patents filed in 2017 and 2018.

What highly-cited research paper demonstrates the use of guanidine thiocyanate in molecular biology?

A landmark 2006 paper titled "The single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction: twenty-something years on" documents the compound's application in molecular biology techniques. This paper has received 2075 citations and is classified under the topic of Molecular Biology Techniques and Applications.

Turn any compound into a complete chemical intelligence landscape

Go beyond static compound data. Cypris resolves identities, patents, papers, and commercial signals into one AI-powered view - so your team can move from a single chemical question to a complete R&D, IP, and market landscape.

Schedule a free trial