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Guanidine thiocyanate

(diaminomethylideneamino) thiocyanate · also: guanidine monothiocyanate, Guanidine thiocyanate, Biotechnology grade

FormulaC2H4N4S
Mol. weight116.142
PubChem CID547739
InChIKeyFZPKSSRLAIBRQA-UHFFFAOYSA-N
SMILESC(#N)SN=C(N)N
11,316Patents
237Research papers
877Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1BASF Plant Science GmbH358
2Kyowa Kirin Co Ltd146
3Dana Farber Cancer Institute Inc142
4F Hoffmann La Roche AG116
5BASF SE109
6Chugai Pharmaceutical Co Ltd97
7Exact Sciences Corp96
8Qiagen GmbH96
9Takeda Pharmaceutical Co Ltd93
10Janssen Biotech Inc85

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes4,986
2C07KPeptides3,955
3C12QMeasuring/testing involving enzymes3,855
4A61KMedicinal preparations3,100
5G01NInvestigating / analysing materials2,302
6A61PTherapeutic activity (drug indications)2,286
7B01L695
8Y02AClimate change adaptation570
9C12YEnzyme nomenclature (EC numbers)528
10C12PFermentation, enzyme processes500

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Extraction of DNA by boiling cells in an alkaline phenol/guanidine thiocyanate solution1999Mayo Clinic in Florida41
Hybridization buffer containing guanidine thiocyanate2018Abbott Molecular Inc6
Preparation method of guanidine thiocyanate2021SUZHOU YACOO SCIENCE Co.,Ltd.1
Quick drying device for guanidine thiocyanate2025Ningxia xinlitai Chemical Co.,Ltd.0
Dewatering device is used in guanidine thiocyanate preparation2022Ningxia xinlitai Chemical Co.,Ltd.0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Amino Acid Enzymes and Metabolism1
2Bone and Dental Protein Studies1
3Genetic factors in colorectal cancer1
4Glaucoma and retinal disorders1
5Hepatitis C virus research1
6MicroRNA in disease regulation1
7Molecular Biology Techniques and Applications1
8Neuroscience and Neuropharmacology Research1
9Orthopaedic implants and arthroplasty1
10Pulmonary Hypertension Research and Treatments1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Alasdair J. EdgarKing's College London6
2Brigitte Berger‐BächiUniversity of Zurich5
3Claudia MiccoloFondazione IRCCS Istituto Neurologico Carlo Besta2
4Jui‐Yoa ChangThe University of Texas at Austin3
5Alfredo FuscoUniversity of Naples Federico II2
6Amane MakinoTohoku University2
7André RosenthalSignature Research (United States)2
8Ashfaque A. MemonAarhus University Hospital2
9Benno MannAugusta-Kranken-Anstalt2
10Bernd HinzmannSignature Research (United States)2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of guanidine thiocyanate?

Guanidine thiocyanate has the molecular formula C2H4N4S with a molecular weight of 116.142. It is also known by its canonical name (diaminomethylideneamino) thiocyanate.

Which organizations hold the most patents related to guanidine thiocyanate?

BASF Plant Science GmbH leads with 358 patents, followed by Kyowa Kirin Co Ltd with 146 patents and Dana Farber Cancer Institute Inc with 142 patents. Other significant patent holders include F Hoffmann La Roche AG, BASF SE, Chugai Pharmaceutical Co Ltd, Exact Sciences Corp, and Qiagen GmbH.

What are the primary patent classification areas for guanidine thiocyanate applications?

The dominant patent classifications are biotechnology and life sciences: C12N (4986 patents), C07K (3955 patents), and C12Q (3855 patents) represent molecular biology and protein engineering applications. Medical and pharmaceutical classifications A61K and A61P account for 3100 and 2286 patents respectively.

What is a landmark application of guanidine thiocyanate in molecular biology?

A foundational application is RNA isolation. The paper titled 'The single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction: twenty-something years on' published in 2006 on the topic of Molecular Biology Techniques and Applications has been cited 2104 times, demonstrating the significance of this compound in standard laboratory protocols.

How has patent activity for guanidine thiocyanate evolved in recent years?

Patent filings have shown growth over the past decade. In 2016 there were 356 patents, increasing to a peak of 438 patents in 2023. Activity in 2024 reached 399 patents, with 877 patents filed in the last 3 years. The total patent portfolio covers 11316 patents.

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