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Glucosepan

(2S)-2-amino-6-[(6R,7S)-2-[(4S)-4-amino-4-carboxybutyl]imino-6,7-dihydroxy-1,5,6,7,8,8a-hexahydroimidazo[4,5-b]azepin-4-yl]hexanoic acid · also: Glucosepane · (2S)-2-Amino-6-((6R,7S)-2-(((S)-4-amino-4-carboxybutyl)amino)-6,7-dihydroxy-6,7,8,8a-tetrahydroimidazo(4,5-b)azepin-4(5H)-yl)hexanoic acid · (alphaS,6R,7S)-alpha-Amino-2-(((4S)-4-amino-4-carboxybutyl)amino)-6,7,8,8a-tetrahydro-6,7-dihydroxyimidazo(4,5-b)azepine-4(5H)-hexanoic acid

FormulaC18H32N6O6
Mol. weight428.49
PubChem CID135565852
InChIKeyJTMICRULXGWYCN-WSOGJNRSSA-N
SMILESC1[C@@H]([C@@H](CN(C2=NC(=NCCC[C@@H](C(=O)O)N)NC21)CCCC[C@@H](C(=O)O)N)O)O
67Patents
24Research papers
18Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Sanofi SA22
2Children's Hospital of Philadelphia2
3Columbia University2
4Affinity (Shanghai) Biopharmaceutical Co Ltd1
5DSM Firmenich AG1
6International Flavors and Fragrances Inc1
7The Pennsylvania State University1
8The University of Tokyo1
9Yale University1

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations40
2C07KPeptides28
3A61PTherapeutic activity (drug indications)14
4A61B10
5A61LSterilising / disinfecting materials8
6G01NInvestigating / analysing materials8
7A61QCosmetics, personal care6
8A23LFoods and beverages (general)5
9C07DHeterocyclic compounds4
10C12NMicroorganisms, enzymes4

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssignee
THE TOTAL SYNTHESIS OF GLUCOSEPANE AND RELATED CHEMICAL REACTIONS, COMPOUNDS AND COMPOSITIONS OBTAINED THEREFROM AND METHODS OF TREATMENT2017

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20162
20172
20183
20191
20202
20211

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Vincent M. MonnierCase Western Reserve University7
2David R. SellCase Western Reserve University6
3Helen L. BirchUniversity College London5
4Anthony NashUniversity College London5
5Nora H. de LeeuwUniversity College London5
6Saul GenuthCase Western Reserve University4
7Wanjie SunGeorge Washington University4
8Naila RabbaniUniversity of Warwick3
9Thomas A. CollierUniversity College London3
10John M. LachinGeorge Washington University3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Glucosepan?

Glucosepan has the molecular formula C18H32N6O6 with a molecular weight of 428.49. Its InChI Key is JTMICRULXGWYCN-WSOGJNRSSA-N. The compound is also known by several synonyms including Glucosepane and is chemically identified as (2S)-2-amino-6-[(6R,7S)-2-[(4S)-4-amino-4-carboxybutyl]imino-6,7-dihydroxy-1,5,6,7,8,8a-hexahydroimidazo[4,5-b]azepin-4-yl]hexanoic acid.

Which organizations hold the most patents related to Glucosepan?

Sanofi SA is the leading patent assignee with 22 patents related to Glucosepan. Other significant patent holders include Children's Hospital of Philadelphia and Columbia University, each with 2 patents. Additional assignees with single patents include Affinity (Shanghai) Biopharmaceutical Co Ltd, DSM Firmenich AG, International Flavors and Fragrances Inc, The Pennsylvania State University, The University of Tokyo, and Yale University.

What is the patent landscape for Glucosepan in recent years?

Patent activity for Glucosepan has grown significantly in recent years. In 2022, there were 15 patents filed, representing the peak year in the dataset. Activity has remained substantial, with 11 patents in 2024 and 7 in 2025. In the last three years (2023-2025), there have been 26 patents total, demonstrating continued commercial and research interest in the compound.

Who are the leading researchers publishing on Glucosepan?

Vincent M. Monnier from Case Western Reserve University is the most prolific author with 7 papers on Glucosepan, followed by David R. Sell, also from Case Western Reserve University, with 6 papers. Helen L. Birch, Anthony Nash, and Nora H. de Leeuw from University College London each have 5 papers. Other significant contributors include Saul Genuth and Wanjie Sun with 4 papers each.

What are the main research and patent focus areas for Glucosepan?

The primary patent classification is A61K (pharmaceuticals with 40 patents), followed by C07K (organic chemistry with 28 patents) and A61P (pharmaceutical preparations for specific therapeutic purposes with 14 patents). Academic research has concentrated on diabetes complications, collagen crosslinking, and connective tissue disorders. Notable papers include studies on skin advanced glycation end products in type 1 diabetes and the association between glucosepane and microvascular complications.

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