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Glucosepan

(2S)-2-amino-6-[(6R,7S)-2-[(4S)-4-amino-4-carboxybutyl]imino-6,7-dihydroxy-1,5,6,7,8,8a-hexahydroimidazo[4,5-b]azepin-4-yl]hexanoic acid · also: Glucosepane

FormulaC18H32N6O6
Mol. weight428.49
PubChem CID135565852
InChIKeyJTMICRULXGWYCN-WSOGJNRSSA-N
SMILESC1[C@@H]([C@@H](CN(C2=NC(=NCCC[C@@H](C(=O)O)N)NC21)CCCC[C@@H](C(=O)O)N)O)O
67Patents
24Research papers
20Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Genzyme Corp22
2Childrens Hospital of Philadelphia CHOP2
3Columbia University2
4Affinity (Shanghai) Biopharmaceutical Co Ltd1
5DSM IP Assets BV1
6Danisco US Inc1
7Penn State Research Foundation1
8Sanofi Aventis Recherche et Developpement1
9University of Tokyo NUC1
10Yale University1

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations40
2C07KPeptides28
3A61PTherapeutic activity (drug indications)14
4A61B10
5A61LSterilising / disinfecting materials8
6G01NInvestigating / analysing materials8
7A61QCosmetics, personal care6
8A23LFoods and beverages (general)5
9C07DHeterocyclic compounds4
10C12NMicroorganisms, enzymes4

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
THE TOTAL SYNTHESIS OF GLUCOSEPANE AND RELATED CHEMICAL REACTIONS, COMPOUNDS AND COMPOSITIONS OBTAINED THEREFROM AND METHODS OF TREATMENT2017YALE UNIVERSITY0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Collagen: Extraction and Characterization1
2Pharmaceutical studies and practices1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Vincent M. MonnierCase Western Reserve University7
2David R. SellCase Western Reserve University6
3Anthony NashUniversity College London5
4Helen L. BirchUniversity College London5
5Nora H. de LeeuwUniversity College London5
6Saul GenuthCase Western Reserve University4
7Wanjie SunGeorge Washington University4
8Attia AnwarUniversity of Warwick3
9Christopher StrauchCase Western Reserve University3
10John M. LachinGeorge Washington University3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition and molecular structure of Glucosepan?

Glucosepan has the molecular formula C18H32N6O6 with a molecular weight of 428.49. Its canonical name is (2S)-2-amino-6-[(6R,7S)-2-[(4S)-4-amino-4-carboxybutyl]imino-6,7-dihydroxy-1,5,6,7,8,8a-hexahydroimidazo[4,5-b]azepin-4-yl]hexanoic acid, and it is also known by the synonym Glucosepane.

Which organizations hold the most patents related to Glucosepan?

Genzyme Corp holds the majority of Glucosepan patents with 22 patents. Other significant patent holders include Childrens Hospital of Philadelphia CHOP and Columbia University in the City of New York, each with 2 patents. Several other organizations including DSM IP Assets BV, Danisco US Inc, Penn State Research Foundation, Sanofi Aventis Recherche et Developpement, University of Tokyo NUC, and Yale University each hold 1 patent.

What are the leading research areas related to Glucosepan?

The primary research focus areas involve diabetes complications and connective tissue disorders. Notable papers address effects of collagen crosslinking on bone material properties, the association between skin collagen glucosepan and microvascular complications in type 1 diabetes, and glycation-mediated changes in human cortical bone. Patents are predominantly classified under pharmaceutical and biotechnological categories, with the largest patent classification being A61K (pharmaceutical compositions) with 40 patents, followed by C07K (organic compounds) with 27 patents.

Who are the most prolific researchers in Glucosepan studies?

Vincent M. Monnier from Case Western Reserve University is the leading researcher with 7 papers on Glucosepan. David R. Sell from the same institution has published 6 papers. Additional prominent researchers include Anthony Nash, Helen L. Birch, and Nora H. de Leeuw, all from University College London, each with 5 papers. Other active researchers include Saul Genuth from Case Western Reserve University with 4 papers and Wanjie Sun from George Washington University with 4 papers.

How has patent activity for Glucosepan changed in recent years?

Patent activity for Glucosepan has shown significant growth, particularly from 2021 onwards. Annual patent filings increased from 3 patents in 2016 to a peak of 15 patents in 2022. In the last three years, there have been 21 patents filed (2022-2024). The total patent portfolio includes 67 patents, with 24 research papers also published in the literature covering related topics.

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