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Glucosepan

(2S)-2-amino-6-[(6R,7S)-2-[(4S)-4-amino-4-carboxybutyl]imino-6,7-dihydroxy-1,5,6,7,8,8a-hexahydroimidazo[4,5-b]azepin-4-yl]hexanoic acid · also: Glucosepane, L-Norleucine, 6-((6R,7S)-2-(((4S)-4-amino-4-carboxybutyl)amino)-6,7,8,8a-tetrahydro-6,7-dihydroxyimidazo(4,5-b)azepin-4(5H)-yl)-, (2S)-2-Amino-6-((6R,7S)-2-(((S)-4-amino-4-carboxybutyl)amino)-6,7-dihydroxy-6,7,8,8a-tetrahydroimidazo(4,5-b)azepin-4(5H)-yl)hexanoic acid, (alphaS,6R,7S)-alpha-Amino-2-(((4S)-4-amino-4-carboxybutyl)amino)-6,7,8,8a-tetrahydro-6,7-dihydroxyimidazo(4,5-b)azepine-4(5H)-hexanoic acid

FormulaC18H32N6O6
Mol. weight428.49
PubChem CID135565852
InChIKeyJTMICRULXGWYCN-WSOGJNRSSA-N
SMILESC1[C@@H]([C@@H](CN(C2=NC(=NCCC[C@@H](C(=O)O)N)NC21)CCCC[C@@H](C(=O)O)N)O)O
67Patents
24Research papers
20Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Genzyme Corp22
2Children's Hospital of Philadelphia2
3Columbia University2
4Affinity (Shanghai) Biopharmaceutical Co Ltd1
5DSM IP Assets BV1
6Danisco US Inc1
7Penn State Research Foundation1
8Sanofi Aventis Recherche et Developpement1
9The University of Tokyo1
10Yale University1

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations40
2C07KPeptides28
3A61PTherapeutic activity (drug indications)14
4A61B10
5A61LSterilising / disinfecting materials8
6G01NInvestigating / analysing materials8
7A61QCosmetics, personal care6
8A23LFoods and beverages (general)5
9C07DHeterocyclic compounds4
10C12NMicroorganisms, enzymes4

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
THE TOTAL SYNTHESIS OF GLUCOSEPANE AND RELATED CHEMICAL REACTIONS, COMPOUNDS AND COMPOSITIONS OBTAINED THEREFROM AND METHODS OF TREATMENT2017YALE UNIVERSITY0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Collagen: Extraction and Characterization1
2Pharmaceutical studies and practices1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Vincent M. MonnierCase Western Reserve University7
2David R. SellCase Western Reserve University6
3Anthony NashUniversity College London5
4Helen L. BirchUniversity College London5
5Nora H. de LeeuwUniversity College London5
6Saul GenuthCase Western Reserve University4
7Wanjie SunGeorge Washington University4
8Attia AnwarUniversity of Warwick3
9Christopher StrauchCase Western Reserve University3
10John M. LachinGeorge Washington University3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Glucosepan?

Glucosepan has the molecular formula C18H32N6O6 with a molecular weight of 428.49. Its canonical IUPAC name is (2S)-2-amino-6-[(6R,7S)-2-[(4S)-4-amino-4-carboxybutyl]imino-6,7-dihydroxy-1,5,6,7,8,8a-hexahydroimidazo[4,5-b]azepin-4-yl]hexanoic acid, and it is also known by the alternate names Glucosepane and Glucosepane.

Which organization holds the most patents related to Glucosepan?

Genzyme Corp holds the largest patent portfolio for Glucosepan with 22 patents, significantly more than other assignees in the space.

What are the primary research areas covered by publications on Glucosepan?

Published research on Glucosepan spans several key areas. A highly-cited 2015 paper examines effects of collagen crosslinking on bone material properties in health and disease. Diabetes complications are a major focus, with 2014 and 2012 publications investigating associations between skin collagen glucosepan and microvascular complications of type 1 diabetes. A 2013 review characterizes glucosepane as a poorly understood advanced glycation end product of growing importance for diabetes and its complications. Bone health research includes a 2018 study assessing glycation-mediated changes in human cortical bone.

What is the patent classification profile for Glucosepan inventions?

Patent filings related to Glucosepan are most heavily concentrated in pharmaceutical preparation classification A61K with 40 patents, followed by peptide/protein chemistry classification C07K with 28 patents. The next most common classifications are pharmaceutical therapeutic applications (A61P) with 14 patents, biomedical analysis and measurement (A61B) with 10 patents, and biomedical materials/devices (A61L) with 8 patents. These classifications reflect a focus on pharmaceutical development and medical applications.

Who are the leading research authors investigating Glucosepan?

Vincent M. Monnier from Case Western Reserve University is the most prolific author with 7 papers on glucosepan research, followed by David R. Sell also from Case Western Reserve University with 6 papers. Researchers from University College London are also prominent contributors: Anthony Nash, Helen L. Birch, and Nora H. de Leeuw each have 5 publications. Additional active researchers include Saul Genuth from Case Western Reserve University with 4 papers and Wanjie Sun from George Washington University with 4 papers.

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