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Fraxidin

7-hydroxy-6,8-dimethoxychromen-2-one · also: Phytodolor, Isofraxidin, iso-Fraxidin, Calycanthogenol, Phosphorustrioxide

FormulaC11H10O5
Mol. weight222.196
PubChem CID5318565
InChIKeyHOEVRHHMDJKUMZ-UHFFFAOYSA-N
SMILESCOC1=C(C(=C2C(=C1)C=CC(=O)O2)OC)O
399Patents
64Research papers
33Patents - last 3 years
7Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Institute of Chinese Materia Medica of China Academy of Chinese Medical Sciences2
2Anhui Medical University1
3CapitalBio Corp1
4Excrx Singapore Pte Ltd1
5Kunming Institute of Botany of CAS1
6Lion Corp1
7South China Botanical Garden of CAS1
8University of Pennsylvania1
9Zhenping Power Supply Co of State Grid Henan Electric Power Co Ltd1

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations112
2A61PTherapeutic activity (drug indications)53
3G01NInvestigating / analysing materials51
4Y02AClimate change adaptation41
5A23LFoods and beverages (general)25
6A61QCosmetics, personal care20
7A23VFoods, foodstuffs - indexing scheme14
8A01G10
9A01NPreservation of bodies; biocides; pest repellents10
10C07DHeterocyclic compounds10

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Endophytic fungi capable of improving content of isofraxidin in Radix Acanthopanacis Semticosi through fermenting Radix Acanthopanacis Semticosi2012HEILONGJIANG UNIVERSITY6
Technology for synchronously extracting isofraxidin and flavonoids compounds from sarcandra glabra and applications thereof2010Sanming Huajian Bioengineering Co.Ltd5
One kind prepares isofraxidin method from Chinese medicinal material of sarcandra glaber2017GUANGDONG PROV. CHINESE MEDICINE HOSPITAL2
Method for extracting isofraxidin2011NANJING ZELANG AGRICULTURAL DEVELOPMENT CO., LTD.2
Isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing isofraxidin crystalline compound2012ZHEJIANG WECOME MEDICINE LNDUSTRY CO., LTD.1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Kaishun BiShenyang Pharmaceutical University6
2Haitao LvHeilongjiang University of Chinese Medicine5
3Hui SunShenyang Pharmaceutical University5
4Xijun WangHeilongjiang University of Chinese Medicine5
5Yanmei ZhangHeilongjiang University of Chinese Medicine5
6Hongxin CaoChina Academy of Chinese Medical Sciences4
7Taisuke YamazakiKohno Clinical Medicine Research Institute4
8Weifeng LiXi'an Jiaotong University4
9Takayoshi TokiwaKohno Clinical Medicine Research Institute3
10Ting FanXi'an Jiaotong University3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular structure and formula of Fraxidin?

Fraxidin has the molecular formula C11H10O5 and a molecular weight of 222.196. Its canonical IUPAC name is 7-hydroxy-6,8-dimethoxychromen-2-one, with an InChI Key of HOEVRHHMDJKUMZ-UHFFFAOYSA-N. The compound is also known by several synonyms including Phytodolor, Isofraxidin, and Calycanthogenol.

Which organizations hold patents for Fraxidin or its analogs?

Patent assignees for Fraxidin-related inventions include the Institute of Materia Medica of CACMS (2 patents), along with single-patent holders including Anhui Medical University, CapitalBio Corp, Excrx Singapore Pte Ltd, Kunming Institute of Botany of CAS, Lion Corp, South China Botanical Garden of CAS, University of Pennsylvania Penn, and Zhenping Power Supply Co of State Grid Henan Electric Power Co Ltd. Notable patents address extraction methods and crystalline forms of isofraxidin from medicinal plants.

What are the primary research areas covered by patents in this field?

Patent classification data shows that Fraxidin-related inventions concentrate in pharmaceutical and medicinal applications, with A61K (Medicinal Preparations) appearing in 112 patents, followed by A61P (Medicinal Preparations for Specific Purposes) in 53 patents and G01N (Measuring and Testing) in 51 patents. Other significant areas include Y02A (Green Technologies), A23L (Food Technology), and A61Q (Cosmetics), reflecting applications across pharmaceuticals, diagnostics, food, and cosmetic sectors.

Who are the leading researchers publishing on Fraxidin's biological effects?

Leading authors in Fraxidin research include Kaishun Bi from Shenyang Pharmaceutical University with 6 papers, and Haitao Lv, Hui Sun, Xijun Wang, and Yanmei Zhang, all with 5 papers each. Lv, Wang, and Zhang are affiliated with Heilongjiang University of Chinese Medicine. Their research has documented Fraxidin's anti-inflammatory effects, ROS-scavenging properties, and interactions with human serum albumin, as well as inhibition of matrix metalloproteinase expression in hepatoma cells.

What patent activity trends are evident for Fraxidin technology?

Patent filing activity peaked in 2017 with 34 patents and has remained active, with 399 total patents in the database. Recent activity shows 35 patents filed in the last 3 years. Academic publishing has been more modest, with 64–66 papers identified and 7 published in the last 3 years. Patent activity in 2024 recorded 17 filings, while papers published in 2024 numbered 4, suggesting sustained industrial and research interest in this compound.

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