Who owns the IP
The organizations most actively patenting around this compound, ranked by referenced patent volume.
| # | Assignee | Patents |
|---|---|---|
| 1 | Kaneka Corp | 50 |
| 2 | Daicel Corp | 49 |
| 3 | Codexis Inc | 33 |
| 4 | Osaka Soda Co Ltd | 31 |
| 5 | Lonza Group AG | 22 |
| 6 | Takasago International Corp | 21 |
| 7 | Zhejiang University of Technology | 21 |
| 8 | JNC Corp | 13 |
| 9 | Mitsubishi Chemical Group Corp | 11 |
| 10 | Hangzhou Normal University | 9 |
Explore the full landscape
This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.
Visit CyprisWhere innovation is concentrated
Patent classifications ranked by volume reveal the technical domains with the most active filing.
| # | Code | Area | Patents |
|---|---|---|---|
| 1 | C12P | Fermentation, enzyme processes | 259 |
| 2 | C12N | Microorganisms, enzymes | 231 |
| 3 | C07C | Acyclic and carbocyclic compounds | 144 |
| 4 | C07D | Heterocyclic compounds | 135 |
| 5 | C12Y | Enzyme nomenclature (EC numbers) | 81 |
| 6 | Y02P | Climate change mitigation: production | 79 |
| 7 | C07B | General methods of organic chemistry | 68 |
| 8 | B01J | Chemical/physical processes (e.g. catalysts) | 28 |
| 9 | C07F | Organometallic compounds | 27 |
| 10 | A61K | Medicinal preparations | 16 |
AI mapped opportunity space
This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.
See Cypris in actionRepresentative patents
The filings that best characterise the patent activity around this compound, most-referenced first.
| Title | Year | Assignee | Cited by |
|---|---|---|---|
| Preparation method of ethyl 4-chloro-3-hydroxybutanoate | 2015 | 6 | |
| Method for preparing (S)-ethyl 4-chloro-3-hydroxybutanoate through asymmetric reduction by use of carbonyl reductase and application thereof | 2013 | 4 | |
| Preparation method and preparation device of ethyl 4-chloro-3-hydroxybutyrate | 2023 | 0 | |
| Method for preparing (S)-ethyl 4-chloro-3-hydroxybutanoate through asymmetric reduction by use of carbonyl reductase and application thereof | 2015 | 0 |
How research activity has moved
Papers published per year for this compound, over the last decade of indexed records.
| Year | Papers |
|---|---|
| 2016 | 4 |
| 2017 | 1 |
| 2023 | 1 |
Who's driving the science
The most-published authors working with this compound, alongside their primary affiliations.
| # | Author | Affiliation | Papers |
|---|---|---|---|
| 1 | Ming Yan | Nanjing Tech University | 9 |
| 2 | Hanjie Ying | Nanjing Tech University | 9 |
| 3 | Lin Xu | Nanjing Tech University | 8 |
| 4 | Hou Cao | State Key Laboratory of Materials-Oriented Chemical Engineering | 7 |
| 5 | Hiroaki Yamamoto | Daicel (Japan) | 6 |
| 6 | Jian Xiong | China National Center for Biotechnology Development | 6 |
| 7 | Yoshinori Kobayashi | Daicel (Japan) | 5 |
| 8 | Yueyuan Zhang | China National Center for Biotechnology Development | 5 |
| 9 | Zhi-Cheng Tao | Changzhou University | 5 |
| 10 | Pingkai Ouyang | State Key Laboratory of Materials-Oriented Chemical Engineering | 5 |
Research leaders
This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.
See Cypris in actionThe literature that defines it
The most-cited papers anchoring the scientific record for this compound.
| Title | Year | Cited by | Topic |
|---|---|---|---|
| Synthesis of optically pure ethyl ( S )-4-chloro-3-hydroxybutanoate by Escherichia coli transformant cells coexpressing the carbonyl reductase and glucose dehydrogenase genes | 2001 | 206 | Bacterial Genetics and Biotechnology |
| Synthesis of optically active ethyl 4-chloro-3-hydroxybutanoate by microbial reduction | 1999 | 73 | Enzyme Catalysis and Immobilization |
| High-level expression of recombinant glucose dehydrogenase and its application in NADPH regeneration | 2006 | 69 | Enzyme Catalysis and Immobilization |
| Synthesis of Ethyl (R)-4-Chloro-3-hydroxybutanoate with RecombinantEscherichia coliCells Expressing (S)-Specific Secondary Alcohol Dehydrogenase | 2002 | 63 | Enzyme Catalysis and Immobilization |
| Upscale production of ethyl (S)-4-chloro-3-hydroxybutanoate by using carbonyl reductase coupled with glucose dehydrogenase in aqueous-organic solvent system | 2014 | 59 | Pharmacogenetics and Drug Metabolism |
Frequently asked questions
Common questions about this compound's patent and research landscape, answered from the underlying data.
What is the molecular formula and weight of ethyl 4-chloro-3-hydroxybutanoate?
Which organizations hold the most patents for this compound?
What biotechnological approach is commonly used to synthesize optically pure forms of this compound?
Which CPC subclasses are most frequently associated with patents for this compound?
What is the publication trend for patents on this compound in recent years?