Who owns the IP
The organizations most actively patenting around this compound, ranked by referenced patent volume.
| # | Assignee | Patents |
|---|---|---|
| 1 | Kaneka Corp | 50 |
| 2 | Daicel Corp | 49 |
| 3 | Codexis Inc | 32 |
| 4 | Osaka Soda Co Ltd | 31 |
| 5 | Lonza AG | 22 |
| 6 | Takasago International Corp | 21 |
| 7 | Zhejiang University of Technology | 21 |
| 8 | JNC Corp | 13 |
| 9 | Mitsubishi Chemical Corp | 11 |
| 10 | Hangzhou Normal University | 9 |
Explore the full landscape
This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.
Visit CyprisWhere innovation is concentrated
Patent classifications ranked by volume reveal the technical domains with the most active filing.
| # | Code | Area | Patents |
|---|---|---|---|
| 1 | C12P | Fermentation, enzyme processes | 259 |
| 2 | C12N | Microorganisms, enzymes | 231 |
| 3 | C07C | Acyclic and carbocyclic compounds | 144 |
| 4 | C07D | Heterocyclic compounds | 135 |
| 5 | C12Y | Enzyme nomenclature (EC numbers) | 81 |
| 6 | Y02P | Climate change mitigation: production | 79 |
| 7 | C07B | General methods of organic chemistry | 68 |
| 8 | B01J | Chemical/physical processes (e.g. catalysts) | 28 |
| 9 | C07F | Organometallic compounds | 27 |
| 10 | A61K | Medicinal preparations | 16 |
AI mapped opportunity space
This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.
See Cypris in actionMost-cited patents
Patents ranked by forward citations reveal the foundational inventions the field continues to build on.
| Title | Year | Assignee | Cited by |
|---|---|---|---|
| Preparation method of ethyl 4-chloro-3-hydroxybutanoate | 2015 | Lianyungang Hongye Chemical Co., Ltd. | 6 |
| Method for preparing (S)-ethyl 4-chloro-3-hydroxybutanoate through asymmetric reduction by use of carbonyl reductase and application thereof | 2013 | NANJING CHANGXINJIA BIOTECHNOLOGY CO., LTD. | 4 |
| Preparation method and preparation device of ethyl 4-chloro-3-hydroxybutyrate | 2023 | Hebei Jiumu Biotechnology Co.,Ltd. | 0 |
| Method for preparing (S)-ethyl 4-chloro-3-hydroxybutanoate through asymmetric reduction by use of carbonyl reductase and application thereof | 2015 | NANJING CHANGXINJIA BIOTECHNOLOGY CO., LTD. | 0 |
Where research is gaining momentum
Research themes ranked by publication activity show where scientific interest is accelerating around this compound.
| # | Research topic | Papers |
|---|---|---|
| 1 | Enzyme function and inhibition | 1 |
Who's driving the science
The most-published authors working with this compound, alongside their primary affiliations.
| # | Author | Affiliation | Papers |
|---|---|---|---|
| 1 | Hanjie Ying | Nanjing Tech University | 9 |
| 2 | Lin Xu | Nanjing Tech University | 9 |
| 3 | Ming Yan | Nanjing Tech University | 9 |
| 4 | Qi Ye | State Key Laboratory of Materials-Oriented Chemical Engineering | 8 |
| 5 | Hou Cao | State Key Laboratory of Materials-Oriented Chemical Engineering | 7 |
| 6 | Jian‐He Xu | East China University of Science and Technology | 4 |
| 7 | Pingkai Ouyang | State Key Laboratory of Materials-Oriented Chemical Engineering | 7 |
| 8 | Hiroaki Yamamoto | Daicel (Japan) | 6 |
| 9 | Jian Xiong | China National Center for Biotechnology Development | 6 |
| 10 | Yong Chen | Nanjing Tech University | 6 |
Research leaders
This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.
See Cypris in actionThe literature that defines it
The most-cited papers anchoring the scientific record for this compound.
| Title | Year | Cited by | Topic |
|---|---|---|---|
| Synthesis of optically pure ethyl ( S )-4-chloro-3-hydroxybutanoate by Escherichia coli transformant cells coexpressing the carbonyl reductase and glucose dehydrogenase genes | 2001 | 206 | Bacterial Genetics and Biotechnology |
| Synthesis of optically active ethyl 4-chloro-3-hydroxybutanoate by microbial reduction | 1999 | 73 | Enzyme Catalysis and Immobilization |
| High-level expression of recombinant glucose dehydrogenase and its application in NADPH regeneration | 2006 | 69 | Enzyme Catalysis and Immobilization |
| Synthesis of Ethyl (<i>R</i>)-4-Chloro-3-hydroxybutanoate with Recombinant<i>Escherichia coli</i>Cells Expressing (<i>S</i>)-Specific Secondary Alcohol Dehydrogenase | 2002 | 63 | Enzyme Catalysis and Immobilization |
| Upscale production of ethyl (S)-4-chloro-3-hydroxybutanoate by using carbonyl reductase coupled with glucose dehydrogenase in aqueous-organic solvent system | 2014 | 59 | Pharmacogenetics and Drug Metabolism |
Frequently asked questions
Common questions about this compound's patent and research landscape, answered from the underlying data.
What is the molecular composition of ethyl 4-chloro-3-hydroxybutanoate?
Which organizations hold the most patents for this compound?
What are the primary research areas associated with this compound?
What notable research has been published on the synthesis of optically pure forms of this compound?
Has patent activity for this compound remained stable in recent years?