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Ekomine

[(1R,5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate nitrate · also: Europen, Metanite, Eumydrin, Eumydrine, Eumidrina, Harvatrate

FormulaC18H26N2O6
Mol. weight366.414
PubChem CID657381
InChIKeyNEDVJZNVOSNSHF-ZNHDNBJUSA-N
SMILESC[N+]1([C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C.[N+](=O)([O-])[O-]
1,777Patents
437Research papers
76Patents - last 3 years
3Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Theravance Biopharma R&D IP LLC170
2Innoviva Inc104
3MedImmune LLC84
4Glaxo Group Ltd63
5Cydex Pharmaceuticals Inc44
6Encysive Pharmaceuticals Inc36
7Chase Pharmaceuticals Corp31
8Merck Sharp & Dohme LLC30
9PTC Therapeutics Inc28
10Stemline Therapeutics Inc26

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)1,184
2A61KMedicinal preparations1,017
3C07DHeterocyclic compounds595
4C07KPeptides212
5A61MDevices for introducing media into the body110
6C12NMicroorganisms, enzymes105
7C07CAcyclic and carbocyclic compounds80
8G01NInvestigating / analysing materials80
9Y02AClimate change adaptation80
10C08LPolymer compositions (blends)69

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Nejiyamas Ekomine Neji1983ROCKFORD HEADED PRODUCTS0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Neuroscience of respiration and sleep2
2Epilepsy research and treatment1
3Heart Rate Variability and Autonomic Control1
4MicroRNA in disease regulation1
5Neuroscience and Neuropharmacology Research1
6Receptor Mechanisms and Signaling1
7Veterinary Pharmacology and Anesthesia1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Bo ÅhrénLund University8
2David H. OverstreetUniversity of California, Los Angeles6
3Hugo Celso Dutra de SouzaUniversidade de São Paulo6
4Anton SimeonovNational Center for Advancing Translational Sciences5
5Hélio César SalgadoUniversidade de São Paulo5
6Ajit JadhavNational Center for Advancing Translational Sciences4
7Cândido Celso CoimbraUniversidade Federal de Minas Gerais4
8Daniel TuckerPerformance Communications4
9Jeffrey M. WitkinWalter Reed Army Institute of Research4
10John R. MartinA.T. Still University4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Role of the Parasympathetic System in Airway Obstruction Due to Emphysema1984262Asthma and respiratory diseases
Selective hepatic vagotomy blocks pancreatic glucagon's satiety effect1983134Gastrointestinal motility and disorders

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition and structure of Ekomine?

Ekomine has the canonical name [(1R,5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate nitrate, with molecular formula C18H26N2O6 and molecular weight 366.414. It is also known by multiple synonyms including Atropine metonitrate, N-Methylatropine nitrate, and Atropine methyl nitrate.

Which organizations hold the most patents related to Ekomine?

The leading patent assignees for Ekomine are Theravance Biopharma R&D IP LLC with 170 patents, Innoviva Inc with 104 patents, MedImmune LLC with 84 patents, and Glaxo Group Ltd with 63 patents.

What are the primary research areas and patent classifications associated with Ekomine?

The dominant patent classifications are A61P (pharmaceutical activity) with 1184 patents and A61K (pharmaceutical preparations) with 1017 patents. Research topics include Neuroscience of respiration and sleep, Heart Rate Variability and Autonomic Control, and Receptor Mechanisms and Signaling.

What are the key published research papers on Ekomine?

Notable papers include 'Role of the Parasympathetic System in Airway Obstruction Due to Emphysema' (1984, 262 citations) addressing asthma and respiratory diseases, and 'Selective hepatic vagotomy blocks pancreatic glucagon's satiety effect' (1983, 131 citations) on gastrointestinal motility and disorders.

How has patent and research activity for Ekomine trended in recent years?

Patent activity shows a general decline from 64 patents in 2016 to 23 in 2025. Paper publication has been sporadic, with peaks in 2019 (5 papers) and 2017 (3 papers). Over the last three years, there have been 79 patents and 3 papers filed or published.

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