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Methyl Salicylate

methyl 2-hydroxybenzoate · also: Dubam · Sloans · Betula · Exagien · Ben Gay · Analgit

FormulaC8H8O3
Mol. weight152.149
PubChem CID4133
InChIKeyOSWPMRLSEDHDFF-UHFFFAOYSA-N
SMILESCOC(=O)C1=CC=CC=C1O
52,477Patents
955Research papers952 indexed in detail
2,538Patents - last 3 years
49Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Sanofi SA1,258
2Procter and Gamble Co1,233
3Colgate Palmolive Co1,045
4Takeda Pharmaceutical Co Ltd664
5Bayer AG654
6Qualcomm Inc583
7Mondelez International Inc471
8Pfizer Inc453
9Saudi Arabian Oil Co419
10Merck and Co Inc341

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations22,924
2A61PTherapeutic activity (drug indications)17,164
3A61QCosmetics, personal care8,934
4C07DHeterocyclic compounds6,900
5H04N6,289
6C07KPeptides3,381
7C07CAcyclic and carbocyclic compounds2,868
8G01NInvestigating / analysing materials2,400
9C12NMicroorganisms, enzymes2,244
10A01NPreservation of bodies; biocides; pest repellents1,923

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
External analgesic lotion containing active ingredients of methyl salicylate and camphor and menthol and method of making such lotion199169
Increasing the flavor strength of anethole, cinnamaldehyde and methyl salicylate with maltol1966Pfizer Inc16
Application of methyl salicylate as bursaphelenchus xylophilus attractant201314
Micro-wave synthetic method for preparing methyl salicylate200814
Stabilized formulations of methyl salicylate, bicarbonate ion, and polyalkylene glycol1999Church and Dwight Co Inc14

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
201622
201723
201812
201920
202023
20219
202218
202318
202422
20259

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Eran PicherskyUniversity of Michigan9
2Tim MarczyloPublic Health England6
3Roland MummWageningen University & Research6
4Birgit PiechullaUniversity of Rostock5
5Hak Soo SeoSeoul National University5
6Hilda WittersFlemish Institute for Technological Research5
7Daniel ValeroUniversitat de Miguel Hernández d'Elx5
8Daniel F. KlessigCornell University5
9Dhirendra KumarEast Tennessee State University4
10József VutsRothamsted Research4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Bacterial Volatiles Induce Systemic Resistance in Arabidopsis20041306Plant-Microbe Interactions and Immunity
Abiotic stresses and induced BVOCs20101123Plant and animal studies
Methyl Salicylate Is a Critical Mobile Signal for Plant Systemic Acquired Resistance20071056Plant-Microbe Interactions and Immunity
Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation2007707Neurobiology and Insect Physiology Research
Root and canal morphology of Burmese mandibular molars2001568Dental materials and restorations

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition of methyl salicylate?

Methyl salicylate has the molecular formula C8H8O3 and a molecular weight of 152.149. Its canonical name is methyl 2-hydroxybenzoate, and it is also known by numerous trade and product names including Wintergreen, Ben Gay, Deep heat, and Radian-b.

Which companies hold the most patents related to methyl salicylate?

Sanofi SA leads with 1258 patents, followed closely by Procter and Gamble Co with 1233 patents and Colgate Palmolive Co with 1045 patents. Other significant patent holders include Takeda Pharmaceutical Co Ltd with 664 patents and Bayer AG with 654 patents.

What are the primary patent classification areas for methyl salicylate?

The largest classification area is A61K (pharmaceutical compositions) with 22924 patents, followed by A61P (therapeutic applications) with 17164 patents and A61Q (cosmetic and personal care applications) with 8934 patents. These classifications reflect the compound's use in pharmaceutical, therapeutic, and personal care products.

What major research topics have focused on methyl salicylate in published literature?

Key research areas include plant-microbe interactions and immunity, with papers showing that methyl salicylate is a critical mobile signal for plant systemic acquired resistance and that bacterial volatiles induce systemic resistance in plants. Additional research has examined methyl salicylate in the context of abiotic stresses and induced volatile organic compounds, as well as its role in olfactory physiology.

How has research and patenting activity for methyl salicylate changed in recent years?

Patent activity has remained relatively stable, with 2538 patents filed in the last 3 years. Peak patent activity occurred in 2018 with 1809 patents. Recent paper publications show 49 papers in the last 3 years, with variable annual output ranging from 9 to 22 papers per year between 2016 and 2024.

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