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Methyl Salicylate

methyl 2-hydroxybenzoate · also: Dubam, Sloans, Betula, Exagien, Ben Gay, Analgit

FormulaC8H8O3
Mol. weight152.149
PubChem CID4133
InChIKeyOSWPMRLSEDHDFF-UHFFFAOYSA-N
SMILESCOC(=O)C1=CC=CC=C1O
52,477Patents
955Research papers
2,666Patents - last 3 years
49Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Aventis Pharmaceuticals Inc1,258
2Procter and Gamble Co1,233
3Colgate Palmolive Co1,045
4Qualcomm Inc563
5Bayer AG551
6Millennium Pharmaceuticals Inc473
7Intercontinental Great Brands LLC451
8SABIC Global Technologies BV387
9General Electric Co302
10Henkel AG and Co KGaA233

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations22,912
2A61PTherapeutic activity (drug indications)17,164
3A61QCosmetics, personal care8,934
4C07DHeterocyclic compounds6,900
5H04N6,288
6C07KPeptides3,381
7C07CAcyclic and carbocyclic compounds2,868
8G01NInvestigating / analysing materials2,400
9C12NMicroorganisms, enzymes2,244
10A01NPreservation of bodies; biocides; pest repellents1,923

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
External analgesic lotion containing active ingredients of methyl salicylate and camphor and menthol and method of making such lotion1991IVY; JEFFERY W.69
Increasing the flavor strength of anethole, cinnamaldehyde and methyl salicylate with maltol1966Pfizer Inc16
Application of methyl salicylate as bursaphelenchus xylophilus attractant2013NANJING FORESTRY UNIVERSITY14
Micro-wave synthetic method for preparing methyl salicylate2008ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY14
Stabilized formulations of methyl salicylate, bicarbonate ion, and polyalkylene glycol1999Church and Dwight Co Inc14

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Insect-Plant Interactions and Control4
2Endodontics and Root Canal Treatments2
3Poisoning and overdose treatments2
4Advancements in Transdermal Drug Delivery1
5Animal Behavior and Reproduction1
6Botanical Research and Chemistry1
7Drug-Induced Adverse Reactions1
8Insects and Parasite Interactions1
9Nematode management and characterization studies1
10Neurobiology and Insect Physiology Research1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Daniel F. KlessigCornell University10
2Alexandre LacosteDélégation Provence et Corse3
3Bill S. HanssonMax Planck Institute for Chemical Ecology6
4Anna‐Karin Borg‐KarlsonKTH Royal Institute of Technology5
5Birgit PiechullaUniversity of Rostock5
6A. Corina VlotCornell University4
7C. Frieke KuperPension Fund for Care and Well-Being4
8C. M. WoodcockRothamsted Research4
9Denise M. TiemanUniversity of Florida4
10Esther PatrickUniversity of California, San Francisco2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Bacterial Volatiles Induce Systemic Resistance in Arabidopsis20041298Plant-Microbe Interactions and Immunity
Abiotic stresses and induced BVOCs20101121Plant and animal studies
Methyl Salicylate Is a Critical Mobile Signal for Plant Systemic Acquired Resistance20071050Plant-Microbe Interactions and Immunity
Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation2007702Neurobiology and Insect Physiology Research
Root and canal morphology of Burmese mandibular molars2001566Dental materials and restorations

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of methyl salicylate?

Methyl salicylate has the molecular formula C8H8O3 and a molecular weight of 152.149 g/mol. It is also known by its canonical name methyl 2-hydroxybenzoate.

What are the main patent assignees working with methyl salicylate?

The leading patent assignees in this field include Aventis Pharmaceuticals Inc with 1258 patents, Procter and Gamble Co with 1233 patents, and Colgate Palmolive Co with 1045 patents. Other significant assignees include Bayer AG, Millennium Pharmaceuticals Inc, and Henkel AG and Co KGaA.

What major patent classifications are associated with methyl salicylate patents?

The most prevalent CPC subclasses for methyl salicylate patents are A61K (with 22912 patents) and A61P (with 17164 patents), followed by A61Q with 8934 patents. These classifications cover pharmaceutical and therapeutic applications. C07D, H04N, and C07K are also significantly represented.

What are the key research topics associated with methyl salicylate in the scientific literature?

Research on methyl salicylate spans several domains, including Insect-Plant Interactions and Control, Plant-Microbe Interactions and Immunity, Neurobiology and Insect Physiology Research, and Animal Behavior and Reproduction. Notable highly-cited papers address its role in plant systemic acquired resistance and its function as a mobile signal in plant defense mechanisms.

How has patenting activity around methyl salicylate trended in recent years?

Patent filings peaked in 2018 with 1809 patents and remained relatively consistent, with 2017 showing 1748 patents and 2022 showing 1782 patents. In the last three years of available data, 2666 patents were filed. Scientific paper output has been more modest, with 49 papers published in the last three years.

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