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Doxorubicin

7-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione · also: Doxil, Rubex, Caelyx, Epi DX, Evacet, Myocet

FormulaC27H29NO11
Mol. weight543.525
PubChem CID1691
InChIKeyAOJJSUZBOXZQNB-UHFFFAOYSA-N
SMILESCC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
103,415Patents
74,649Research papers
9,055Patents - last 3 years
3,233Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Genentech Inc2,368
2Novartis AG1,398
3Merck Sharp and Dohme LLC1,266
4AstraZeneca AB1,263
5Takeda Pharmaceutical Co Ltd1,097
6Bristol Myers Squibb Co1,011
7Abbott Cardiovascular Systems Inc899
8University of Texas System759
9University of California San Diego UCSD741
10Vertex Pharmaceuticals Inc682

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)77,593
2A61KMedicinal preparations75,927
3C07DHeterocyclic compounds26,181
4C07KPeptides24,990
5C12NMicroorganisms, enzymes11,597
6G01NInvestigating / analysing materials9,975
7Y02AClimate change adaptation5,515
8C12QMeasuring/testing involving enzymes5,081
9A61LSterilising / disinfecting materials4,107
10C07CAcyclic and carbocyclic compounds4,008

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use2003Immunogen Inc505
Bis-anthracyclines with high activity against doxorubicin resistant tumors1999CHAIRES; JONATHAN B.98
Derivatives of doxorubicine, their preparation and use1981INSTITUT INTERNATIONAL DE PATHOLOGIE CELLULAIRE ET MOLECULAIRE74
Preparation of injectable doxorubicin/liposome suspension1990LIPOSOME TECHNOLOGY, INC.61
Liposome/doxorubicin composition and method1990Hadassah Medical Organization52

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Lymphoma Diagnosis and Treatment110
2Nanoparticle-Based Drug Delivery104
3Chemotherapy-induced cardiotoxicity and mitigation76
4Drug Transport and Resistance Mechanisms57
5Cancer Treatment and Pharmacology41
6Sarcoma Diagnosis and Treatment33
7Breast Cancer Treatment Studies30
8Bladder and Urothelial Cancer Treatments25
9Hepatocellular Carcinoma Treatment and Prognosis23
10Cancer therapeutics and mechanisms20

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Gabriel N. HortobágyiThe University of Texas MD Anderson Cancer Center92
2Aman U. BuzdarBreast Cancer Care69
3Andrew V. SchallyTulane University47
4Jun WangAnhui University46
5Andreas EngertUniversity Hospital Cologne43
6Wei ZhangChinese Academy of Medical Sciences & Peking Union Medical College38
7Gianni BonadonnaFondazione IRCCS Istituto Nazionale dei Tumori36
8Hagop M. KantarjianThe University of Texas MD Anderson Cancer Center30
9Xin WangAnhui University33
10Karel UlbrichCzech Academy of Sciences, Institute of Macromolecular Chemistry32

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Doxorubicin?

Doxorubicin has the molecular formula C27H29NO11 and a molecular weight of 543.525 g/mol. Its canonical name is 7-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione.

How extensive is the patent and publication coverage for Doxorubicin?

Doxorubicin has substantial intellectual property and scientific literature coverage, with 103,415 total patents and 74,649 papers in the database. In the last 3 years, there were 9,210 patents and 3,212 papers, indicating continued active research and development.

Which companies hold the most patents related to Doxorubicin?

The leading patent assignees for Doxorubicin-related inventions are Genentech Inc with 2,368 patents, Novartis AG with 1,398 patents, Merck Sharp and Dohme LLC with 1,266 patents, AstraZeneca AB with 1,263 patents, and Takeda Pharmaceutical Co Ltd with 1,097 patents.

What are the major research topics associated with Doxorubicin studies?

The primary research areas focus on Lymphoma Diagnosis and Treatment (103 papers), Nanoparticle-Based Drug Delivery (95 papers), Chemotherapy-induced cardiotoxicity and mitigation (72 papers), and Drug Transport and Resistance Mechanisms (56 papers). These topics reflect both therapeutic applications and safety concerns.

What is a notable early patent on Doxorubicin derivatives?

A foundational patent is US-4296105-A from 1981 titled 'Derivatives of doxorubicine, their preparation and use' assigned to Institut International de Pathologie Cellulaire et Moleculaire, which has been cited 74 times and established early work on doxorubicin chemical modifications.

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