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Doxorubicin

(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione · also: Rubex · Doxil · Caelyx · Adrosal · Lipodox · Doxolem

FormulaC27H29NO11
Mol. weight543.525
PubChem CID31703
InChIKeyAOJJSUZBOXZQNB-TZSSRYMLSA-N
SMILESC[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
92,968Patents
68,950Research papers50,019 indexed in detail
7,821Patents - last 3 years
3,280Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Roche Holding AG2,307
2Bristol Myers Squibb Co1,896
3Pfizer Inc1,317
4Novartis AG1,305
5Abbott Laboratories1,157
6AstraZeneca PLC1,144
7Merck and Co Inc1,079
8Takeda Pharmaceutical Co Ltd1,038
9Gilead Sciences Inc952
10University of California779

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)70,161
2A61KMedicinal preparations69,523
3C07DHeterocyclic compounds23,205
4C07KPeptides22,840
5C12NMicroorganisms, enzymes10,028
6G01NInvestigating / analysing materials8,888
7Y02AClimate change adaptation5,040
8C12QMeasuring/testing involving enzymes4,416
9A61LSterilising / disinfecting materials3,834
10C07CAcyclic and carbocyclic compounds3,553

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use2003AbbVie Inc505
Bis-anthracyclines with high activity against doxorubicin resistant tumors199998
Derivatives of doxorubicine, their preparation and use198174
Preparation of injectable doxorubicin/liposome suspension199061
Liposome/doxorubicin composition and method1990Hadassah Medical Organization52

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20161,699
20171,725
20181,780
20191,830
20201,827
20211,615
20221,501
20231,251
20241,406
2025623

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Gabriel N. HortobágyiThe University of Texas MD Anderson Cancer Center91
2Aman U. BuzdarBreast Cancer Care48
3Andrew V. SchallyTulane University44
4Randy D. GascoyneBC Cancer Agency43
5Joseph M. ConnorsBC Cancer Agency42
6Karel UlbrichCzech Academy of Sciences, Institute of Macromolecular Chemistry41
7Andreas EngertUniversity Hospital Cologne39
8Gianni BonadonnaFondazione IRCCS Istituto Nazionale dei Tumori37
9Tomáš EtrychCzech Academy of Sciences, Institute of Macromolecular Chemistry34
10Xuesi ChenChinese Academy of Sciences32

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Doxorubicin?

Doxorubicin has the molecular formula C27H29NO11 and a molecular weight of 543.525 g/mol.

Which organizations hold the most patents related to Doxorubicin?

The top patent assignees for Doxorubicin-related inventions are Roche Holding AG with 2,307 patents, Bristol Myers Squibb Co with 1,896 patents, and Pfizer Inc with 1,317 patents.

What are some common trade names or synonyms for Doxorubicin?

Doxorubicin is marketed and known under multiple trade names and synonyms, including Adriamycin, Rubex, Doxil, and Caelyx, among others.

What research topics are most prominently associated with Doxorubicin publications?

Key research topics include Nanoparticle-Based Drug Delivery, as evidenced by a 2012 comprehensive review titled 'Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems' with 2,470 citations, as well as Ferroptosis and cancer prognosis, Autophagy in Disease and Therapy, and DNA and Nucleic Acid Chemistry.

How has the patent filing rate for Doxorubicin-related inventions changed in recent years?

Patent filings related to Doxorubicin have shown growth from 3,116 in 2016 to a peak of 4,396 in 2023, though filings declined to 3,999 in 2024 and 2,168 in 2025. Over the last 3 years, there have been 7,821 total patent filings.

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