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Doxorubicin

(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione · also: Rubex, Doxil, Caelyx, Doxolem, Lipodox, Adrosal

FormulaC27H29NO11
Mol. weight543.525
PubChem CID31703
InChIKeyAOJJSUZBOXZQNB-TZSSRYMLSA-N
SMILESC[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
92,968Patents
68,950Research papers
8,228Patents - last 3 years
3,280Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Genentech Inc1,833
2Novartis AG1,293
3AstraZeneca AB1,095
4Merck Sharp & Dohme LLC1,073
5Takeda Pharmaceutical Co Ltd1,017
6Abbott Cardiovascular Systems Inc911
7Bristol Myers Squibb Co863
8The University of Texas System713
9Vertex Pharmaceuticals Inc675
10University of California, San Diego664

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)70,145
2A61KMedicinal preparations69,509
3C07DHeterocyclic compounds23,202
4C07KPeptides22,832
5C12NMicroorganisms, enzymes10,023
6G01NInvestigating / analysing materials8,881
7Y02AClimate change adaptation5,030
8C12QMeasuring/testing involving enzymes4,415
9A61LSterilising / disinfecting materials3,834
10C07CAcyclic and carbocyclic compounds3,553

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use2003Immunogen Inc505
Bis-anthracyclines with high activity against doxorubicin resistant tumors1999CHAIRES; JONATHAN B.98
Derivatives of doxorubicine, their preparation and use1981INSTITUT INTERNATIONAL DE PATHOLOGIE CELLULAIRE ET MOLECULAIRE74
Preparation of injectable doxorubicin/liposome suspension1990LIPOSOME TECHNOLOGY, INC.61
Liposome/doxorubicin composition and method1990Hadassah Medical Organization52

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Lymphoma Diagnosis and Treatment135
2Nanoparticle-Based Drug Delivery131
3Chemotherapy-induced cardiotoxicity and mitigation100
4Drug Transport and Resistance Mechanisms70
5Cancer Treatment and Pharmacology52
6Sarcoma Diagnosis and Treatment37
7Breast Cancer Treatment Studies36
8Bladder and Urothelial Cancer Treatments29
9Hepatocellular Carcinoma Treatment and Prognosis27
10Cancer therapeutics and mechanisms23

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Gabriel N. HortobágyiThe University of Texas MD Anderson Cancer Center88
2Aman U. BuzdarBreast Cancer Care69
3Andrew V. SchallyTulane University47
4Jun WangAnhui University46
5Andreas EngertUniversity Hospital Cologne43
6Wei ZhangChinese Academy of Medical Sciences & Peking Union Medical College39
7Hagop M. KantarjianThe University of Texas MD Anderson Cancer Center31
8Gianni BonadonnaFondazione IRCCS Istituto Nazionale dei Tumori34
9Xin WangAnhui University33
10Karel UlbrichCzech Academy of Sciences, Institute of Macromolecular Chemistry32

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Doxorubicin?

Doxorubicin has the molecular formula C27H29NO11 and a molecular weight of 543.525. Its canonical IUPAC name is (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione.

Which organizations hold the most patents related to Doxorubicin?

The leading patent assignees in the Doxorubicin space are Genentech Inc with 1833 patents, Novartis AG with 1293 patents, and AstraZeneca AB with 1095 patents. Other major assignees include Merck Sharp & Dohme LLC, Takeda Pharmaceutical Co Ltd, and Abbott Cardiovascular Systems Inc.

What are the primary research areas for Doxorubicin in the scientific literature?

The major research topics associated with Doxorubicin include Lymphoma Diagnosis and Treatment with 135 papers, Nanoparticle-Based Drug Delivery with 131 papers, and Chemotherapy-induced cardiotoxicity and mitigation with 100 papers. Other significant areas include Drug Transport and Resistance Mechanisms and Breast Cancer Treatment Studies.

What are notable patent examples in Doxorubicin derivative development?

Key patents include a 2003 patent titled Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use with 505 citations, a 1999 patent on Bis-anthracyclines with high activity against doxorubicin resistant tumors with 98 citations, and a 1981 patent on Derivatives of doxorubicine with 74 citations. Patents on liposomal formulations from 1990 document preparation methods for injectable doxorubicin/liposome suspensions.

Who are leading researchers publishing on Doxorubicin?

Gabriel N. Hortobágyi from The University of Texas MD Anderson Cancer Center is the most prolific author with 88 papers on Doxorubicin-related topics. Other leading researchers include Aman U. Buzdar with 69 papers and Andrew V. Schally from Tulane University with 47 papers. Jun Wang from Anhui University and Andreas Engert from University Hospital Cologne are also among the top contributors.

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