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Dns-lysine

(2S)-2-amino-6-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]hexanoic acid · also: dansyllysine · n6-dansyl lysine · N6-dansyl-L-lysine · ne-dansyl-l-lysine · N(6)-dansyl-L-lysine · epsilon-dansyllysine

FormulaC18H25N3O4S
Mol. weight379.475
PubChem CID121945
InChIKeyVQPRNSWQIAHPMS-HNNXBMFYSA-N
SMILESCN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)NCCCC[C@@H](C(=O)O)N
461Patents
29Research papers
14Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Promega Corp102
2Xerox Holdings Corp56
3New York Blood Center20
4Danaher Corp17
5University of Massachusetts System17
6Boston University11
7Lockheed Martin Corp9
8Hebrew University of Jerusalem8
9University of California8
10Bausch Health Companies Inc7

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1G01NInvestigating / analysing materials221
2C12NMicroorganisms, enzymes140
3C07KPeptides136
4A61KMedicinal preparations123
5C12QMeasuring/testing involving enzymes109
6A61PTherapeutic activity (drug indications)87
7Y10SCross-reference (legacy)77
8C12YEnzyme nomenclature (EC numbers)70
9C07DHeterocyclic compounds64
10C07FOrganometallic compounds45

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin1998Leland Stanford Junior University1,611
IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS2018Camp4 Therapeutics Corp203
Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis1999Lockheed Martin Corp681
Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis2000Lockheed Martin Corp460
Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns1996407

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1George M. HahnStanford University8
2Glenn C. RiceStanford University7
3John P. LovejoyCalifornia Institute for Medical Research4
4George A. FisherStanford University4
5Gillian M. K. HumphriesCalifornia Institute for Medical Research3
6Ichio ShimadaThe University of Tokyo3
7Shiao Y. WooStanford University3
8Koichi KatoNagoya City University3
9Robin L. AndersonStanford University3
10Gilliam M. K. HumphriesMolecular Devices2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Dns-lysine?

Dns-lysine has the molecular formula C18H25N3O4S with a molecular weight of 379.475. Its canonical IUPAC name is (2S)-2-amino-6-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]hexanoic acid, with the InChI Key VQPRNSWQIAHPMS-HNNXBMFYSA-N.

Which organizations hold the most patents related to Dns-lysine?

Promega Corp leads with 102 patents, followed by Xerox Holdings Corp with 56 patents, and New York Blood Center with 20 patents. Other significant patent holders include Danaher Corp and University of Massachusetts System, each with 17 patents.

What is the current patent activity trend for Dns-lysine?

Over 461 total patents have been identified involving Dns-lysine. In the last 3 years, 14 patents were filed. Patent activity peaked in 2022 with 13 patents, followed by 11 in 2023 and 8 in 2024. Activity in 2025 has been limited to 2 patents so far.

What are the primary technology fields associated with Dns-lysine patents?

The most prevalent CPC subclass is G01N (measuring, testing, or analyzing materials) with 221 patents, followed by C12N (biochemistry and biotechnology) with 140 patents and C07K (organic chemistry of peptides) with 136 patents. Other significant fields include A61K (pharmaceuticals) with 123 patents and C12Q (chemical analysis and testing) with 109 patents.

What research topic is directly associated with Dns-lysine in the scientific literature?

A 1983 paper titled "Cholesterol-free phospholipid domains may be the membrane feature selected by Nε-dansyl-L-lysine and merocyanine 540" addresses Lipid Membrane Structure and Behavior, with 48 citations. This work directly investigates the compound's interaction with cellular membranes.

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