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Deoxycholic Acid

(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid · also: 3alpha, Degalol, Kybella, Pyrochol, Droxolan, Septochol

FormulaC24H40O4
Mol. weight392.58
PubChem CID222528
InChIKeyKXGVEGMKQFWNSR-LLQZFEROSA-N
SMILESC[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
90,391Patents
8,536Research papers
6,421Patents - last 3 years
145Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Alnylam Pharmaceuticals Inc1,334
2Human Genome Sciences Inc966
3Ionis Pharmaceuticals Inc835
4Fujifilm Corp831
5GlaxoSmithKline Biologicals SA791
6University of California, San Diego767
7Novartis AG647
8Takeda Pharmaceutical Co Ltd578
9Novo Nordisk AS466
10Procter and Gamble Co459

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations54,965
2A61PTherapeutic activity (drug indications)49,139
3C07KPeptides24,679
4C12NMicroorganisms, enzymes23,903
5G01NInvestigating / analysing materials14,056
6C07DHeterocyclic compounds8,654
7C12QMeasuring/testing involving enzymes8,486
8Y02AClimate change adaptation6,042
9Y10SCross-reference (legacy)3,988
10C12YEnzyme nomenclature (EC numbers)3,707

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Process for preparing 3alpha(beta)-7alpha(beta)-dihydroxy-6alpha(beta)-alkyl-5beta-cholanic acid2008Intercept Pharmaceuticals Inc63
3alpha, 9alpha-epoxy steroids of the androstane and pregnane series1962GD Searle LLC31
Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits2014Allergan Sales LLC29
Formulations of deoxycholic acid and salts thereof2013Allergan Sales LLC25
Formulations of deoxycholic acid and salts thereof2012Allergan Sales LLC25

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Drug Transport and Resistance Mechanisms40
2Advanced Drug Delivery Systems6
3Antifungal resistance and susceptibility6
4HIV Research and Treatment5
5Pharmacogenetics and Drug Metabolism5
6Bacteriophages and microbial interactions4
7Gallbladder and Bile Duct Disorders4
8Lipid Membrane Structure and Behavior4
9Monoclonal and Polyclonal Antibodies Research4
10Neonatal Health and Biochemistry4

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Youngro ByunSeoul National University34
2Alan F. HofmannUniversity of California San Diego31
3Junichi GotoTohoku University15
4Harris BernsteinUniversity of Arizona14
5A. StiehlHeidelberg University12
6Carol BernsteinUniversity of Arizona12
7Claire M. PayneUniversity of Arizona10
8Aldo RodaUniversity of Bologna10
9R. H. DowlingGuy's Hospital10
10Hyun Tae MoonGS Caltex (South Korea)9

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Assay of proteins in the presence of interfering materials19763206Mass Spectrometry Techniques and Applications
Solubilization of membranes by detergents19752938Lipid Membrane Structure and Behavior
Identification of a Nuclear Receptor for Bile Acids19992697Drug Transport and Resistance Mechanisms
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome20132212Gut microbiota and health
lincRNAs act in the circuitry controlling pluripotency and differentiation20111903MicroRNA in disease regulation

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Deoxycholic Acid?

Deoxycholic Acid has the molecular formula C24H40O4 with a molecular weight of 392.58. Its InChI Key is KXGVEGMKQFWNSR-LLQZFEROSA-N.

What are the major patent assignees working with Deoxycholic Acid?

The top patent assignees in this field include Alnylam Pharmaceuticals Inc, Human Genome Sciences Inc, Ionis Pharmaceuticals Inc, Fujifilm Corp, and GlaxoSmithKline Biologicals SA. These represent the most active organizations across the 90,391 total patents covering Deoxycholic Acid.

Which research topics are most commonly associated with Deoxycholic Acid publications?

The leading research topics include Drug Transport and Resistance Mechanisms, Advanced Drug Delivery Systems, Antifungal resistance and susceptibility, HIV Research and Treatment, and Pharmacogenetics and Drug Metabolism. A particularly influential paper on Identification of a Nuclear Receptor for Bile Acids has received 2,697 citations.

Who are the most prolific authors publishing on Deoxycholic Acid?

Leading researchers include Youngro Byun from Seoul National University with 34 papers, Alan F. Hofmann from University of California San Diego with 31 papers, and Junichi Goto from Tohoku University with 15 papers. These authors have made significant contributions to the literature on this compound.

How has patent and publication activity changed in recent years?

Patent filings remain robust, with 3,162 patents filed in 2024 and 1,620 in 2025 (partial year), following sustained activity of approximately 3,100–3,400 patents annually from 2016–2023. Academic publications show a declining trend, peaking at 123 papers in 2017 and declining to 32 papers in 2025 (partial year), reflecting a shift toward patent-driven development.

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