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5-Aza-1-(2-deoxy-beta-D-ribofuranosyl)cytosine

4-amino-1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

FormulaC8H12N4O4
Mol. weight228.208
PubChem CID24848394
InChIKeyXAUDJQYHKZQPEU-YSLANXFLSA-N
SMILESC1[C@@H](O[C@@H](C1O)CO)N2C=NC(=NC2=O)N
750Patents
113Research papers
65Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Bristol Myers Squibb Co40
2Massachusetts Institute of Technology35
3Otsuka Holdings Co Ltd33
4Mass General Brigham Inc25
5Institut National de la Santé et de la Recherche Médicale20
6German Cancer Research Center19
7The University of Texas System15
8University of Southern California14
9Harvard University13
10Centre National de la Recherche Scientifique12

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)522
2A61KMedicinal preparations513
3C12NMicroorganisms, enzymes205
4C12QMeasuring/testing involving enzymes190
5C07KPeptides164
6G01NInvestigating / analysing materials122
7C07DHeterocyclic compounds82
8C07HSugars and derivatives82
9C12YEnzyme nomenclature (EC numbers)38
10Y02AClimate change adaptation34

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
SPATIAL ANALYSIS OF DNA METHYLATION202110X Genomics Inc101
WNT PATHWAY STIMULATION IN REPROGRAMMING SOMATIC CELLS2009Massachusetts Institute of Technology146
MODULATORS OF TOLL-LIKE RECPTORS FOR THE TREATMENT OF HIV2017Gilead Sciences Inc53
IMPROVED CANCER THERAPY BASED ON TUMOR ASSOCIATED ANTIGENS DERIVED FROM CYCLIN D12011Immatics NV85
COMPOSITIONS AND METHODS FOR ENHANCING CELL REPROGRAMMING2010Massachusetts Institute of Technology88

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1James G. HermanJohns Hopkins University4
2John D. MinnaThe University of Texas Southwestern Medical Center3
3Jorge OliveiraInstituto Português de Oncologia Francisco Gentil2
4Rolf I. SkotheimUniversity of Oslo2
5Vundavalli V. MurtyCancer Genetics (United States)2
6Eline MenuVrije Universiteit Brussel2
7Els Van ValckenborghVrije Universiteit Brussel2
8Qing ChangPrince of Wales Hospital2
9Jane A. PlumbCancer Research UK2
10Joäo CarvalhoInstituto Português de Oncologia Francisco Gentil2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of 5-Aza-1-(2-deoxy-beta-D-ribofuranosyl)cytosine?

5-Aza-1-(2-deoxy-beta-D-ribofuranosyl)cytosine has the molecular formula C8H12N4O4 and a molecular weight of 228.208.

Which organizations hold the most patents for this compound?

Bristol Myers Squibb Co leads with 40 patents, followed by Massachusetts Institute of Technology with 35 patents, and Otsuka Holdings Co Ltd with 33 patents. Other significant patent holders include Mass General Brigham Inc with 25 patents and Institut National de la Santé et de la Recherche Médicale with 20 patents.

What is the overall patent and publication activity for this compound?

There are 750 total patents and 113 papers in the database covering this compound. In the last three years, 65 new patents were filed, though paper publication activity has been inactive during this recent period.

What are the primary technology classifications associated with patents for this compound?

The most prevalent patent classifications are pharmaceutical and biomedical in nature. Classification A61P appears in 522 patents, A61K in 513 patents, and C12N in 205 patents. Diagnostic and analytical methods are well represented with C12Q in 190 patents and G01N in 122 patents.

What research topics have been covered in the published literature on this compound?

Published literature has focused on epigenetics and DNA methylation, including mechanisms of action of DNA methyltransferase inhibitors, epigenetic reprogramming, and drug resistance strategies. Cancer-related research, including studies on metastasis and tumor suppressor genes, is also documented in the literature.

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