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D-Tetrahydropalmatine

(13aR)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline · also: corydalis B, (+)-Corydalis B, Tetrahydropalmatin, Corydalis alkaloid B, Tetrahydropalmatine D-, (+)-Tetrahydropalmatine

FormulaC21H25NO4
Mol. weight355.434
PubChem CID969488
InChIKeyAEQDJSLRWYMAQI-QGZVFWFLSA-N
SMILESCOC1=C(C2=C(C[C@@H]3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
147Patents
338Research papers
14Patents - last 3 years
20Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Shanghai Institute of Materia Medica9
2Institute of Materia Medica, CAMS&PUMC3
3Xel Pharmaceuticals Inc3
4Zhejiang University3
5Institute of Chinese Materia Medica of China Academy of Chinese Medical Sciences2
6Zhejiang Chinese Medical University2
7Guangdong Yifang Pharmaceutical Co Ltd1
8Jiyang College of Zhejiang A&F University1
9Shimadzu China Co Ltd1
10Xinjiang Technical Institute of Physics & Chemistry1

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations68
2A61PTherapeutic activity (drug indications)54
3C07DHeterocyclic compounds32
4G01NInvestigating / analysing materials10
5Y02AClimate change adaptation6
6A61QCosmetics, personal care4
7A23LFoods and beverages (general)3
8A23VFoods, foodstuffs - indexing scheme3
9C07BGeneral methods of organic chemistry3
10C07CAcyclic and carbocyclic compounds3

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Corydalis B long-acting preparation and its preparing method2005MENG FANHAO5
Application of the tetrahydropalmatine in anti-toxicity of cisplatin medicine is prepared2017Zhejiang University4
Levo-tetrahydropalmatine transdermal drug delivery preparation2011ZHEJIANG ACADEMY OF MEDICAL SCIENCES4
Application of tetrahydropalmatine enantiomers in preparation of P-glycoprotein inhibitor2011Zhejiang University4
A kind of extracting method of tetrahydropalmatine2019SICHUAN XUYANG PHARMACEUTICAL CO., LTD.2

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Berberine and alkaloids research1
2Chemical synthesis and alkaloids1
3Ion channel regulation and function1
4Neuroscience and Neuropharmacology Research1
5Neurotransmitter Receptor Influence on Behavior1
6Pharmacogenetics and Drug Metabolism1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Guo-Zhang JinShanghai Institute of Materia Medica14
2Guorong FanSecond Military Medical University11
3Huidi JiangZhejiang University7
4Yifeng ChaiSecond Military Medical University7
5Zhanying HongSecond Military Medical University6
6Fan YangCapital Medical University5
7Hanfa ZouDalian Institute of Chemical Physics5
8Hongliang SuShanxi Medical University5
9Jia Bei WangUniversity of Maryland, Baltimore5
10Bin HsuShanghai Institute of Materia Medica4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of D-Tetrahydropalmatine?

D-Tetrahydropalmatine has the molecular formula C21H25NO4 and a molecular weight of 355.434 g/mol. Its canonical IUPAC name is (13aR)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline.

Which organizations hold the most patents related to D-Tetrahydropalmatine?

The Shanghai Institute of Materia Medica holds the most patents with 9 filed. Other significant patent holders include the Institute of Materia Medica, CAMS&PUMC, Xel Pharmaceuticals Inc, and Zhejiang University, each with 3 patents.

What are the primary research topics associated with D-Tetrahydropalmatine in published literature?

Research on D-Tetrahydropalmatine spans multiple areas including Berberine and alkaloids research, Chemical synthesis and alkaloids, Ion channel regulation and function, Neuroscience and Neuropharmacology Research, Neurotransmitter Receptor Influence on Behavior, and Pharmacogenetics and Drug Metabolism.

What are the most cited publications on D-Tetrahydropalmatine and their research focus?

The most highly cited paper is 'Protective effect of tetrahydropalmatine against d-galactose induced memory impairment in rat' with 119 citations, focusing on Antioxidants, Aging, and Portulaca oleracea. Another top paper with 118 citations addresses 'Determination of dl-tetrahydropalmatine in Corydalis yanhusuo' using analytical chemistry methods. A paper on L-Tetrahydropalamatine as a potential treatment for cocaine addiction received 102 citations.

What are the primary patent classification areas for D-Tetrahydropalmatine patents?

The largest patent classification is A61K (pharmaceutical compositions) with 68 patents, followed by A61P (therapeutic applications) with 54 patents, and C07D (heterocyclic compounds) with 32 patents. Additional significant classifications include G01N (measuring and testing), Y02A (environmental technologies), and A61Q (cosmetics and personal care).

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