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Cy5.5

(2Z)-2-[(2E,4E)-5-[3-(5-carboxypentyl)-1,1-dimethyl-6,8-disulfobenzo[e]indol-3-ium-2-yl]penta-2,4-dienylidene]-3-ethyl-1,1-dimethyl-8-sulfobenzo[e]indole-6-sulfonate

FormulaC41H44N2O14S4
Mol. weight917.043
PubChem CID131704516
InChIKeyLIZDKDDCWIEQIN-UHFFFAOYSA-N
SMILESCCN\1C2=C(C3=C(C=C2)C(=CC(=C3)S(=O)(=O)O)S(=O)(=O)[O-])C(/C1=C/C=C/C=C/C4=[N+](C5=C(C4(C)C)C6=C(C=C5)C(=CC(=C6)S(=O)(=O)O)S(=O)(=O)O)CCCCCC(=O)O)(C)C
12,593Patents
375Research papers
7,883Patents - last 3 years
24Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Becton Dickinson and Co242
2F Hoffmann La Roche AG214
310X Genomics Inc174
4University of California, San Diego143
5Harvard University132
6Leland Stanford Junior University117
7Regeneron Pharmaceuticals Inc114
8Institut National de la Santé et de la Recherche Médicale103
9Amgen Inc100
10Massachusetts Institute of Technology96

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations7,063
2A61PTherapeutic activity (drug indications)6,084
3C07KPeptides5,054
4C12NMicroorganisms, enzymes4,011
5G01NInvestigating / analysing materials3,550
6C12QMeasuring/testing involving enzymes3,021
7Y02AClimate change adaptation1,064
8C07DHeterocyclic compounds614
9C12YEnzyme nomenclature (EC numbers)439
10B01L303

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
CY5.5 carboxylic acid marked heat shock protein 90-II type fluorescent probe, preparation method and application thereof2025AFFILIATED HOSPITAL OF GUANGDONG MEDICAL UNIVERSITY0
Heat shock protein 90-I type fluorescent probe coupled with CY5.5 carboxylic acid, preparation method and application thereof2025AFFILIATED HOSPITAL OF GUANGDONG MEDICAL UNIVERSITY0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Nanoplatforms for cancer theranostics2
2Optical Imaging and Spectroscopy Techniques2
3S100 Proteins and Annexins2
4Cancer Research and Treatments1
5Cardiac Imaging and Diagnostics1
6Glycosylation and Glycoproteins Research1
7Lanthanide and Transition Metal Complexes1
8Lymphatic System and Diseases1
9Monoclonal and Polyclonal Antibodies Research1
10Nanoparticle-Based Drug Delivery1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Andreas FaustUniversity of Münster9
2Christoph BremerUniversity Hospital Münster9
3Alexei BogdanovMassachusetts General Hospital8
4Ick Chan KwonKorea Institute of Science and Technology8
5Anna MooreMassachusetts General Hospital7
6Carsten HöltkeUniversity Hospital Münster7
7Ralph WeisslederMassachusetts General Hospital7
8Catherine CannetNovartis Institutes for BioMedical Research3
9Kwangmeyung KimKorea Institute of Science and Technology6
10Lee JosephsonHarvard University6

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Cy5.5?

Cy5.5 has the molecular formula C41H44N2O14S4 with a molecular weight of 917.043. Its canonical chemical name is (2Z)-2-[(2E,4E)-5-[3-(5-carboxypentyl)-1,1-dimethyl-6,8-disulfobenzo[e]indol-3-ium-2-yl]penta-2,4-dienylidene]-3-ethyl-1,1-dimethyl-8-sulfobenzo[e]indole-6-sulfonate.

Which organizations hold the most patents involving Cy5.5?

The top patent holders are Becton Dickinson and Co with 242 patents, F Hoffmann La Roche AG with 214 patents, and 10X Genomics Inc with 174 patents. Other significant patent holders include University of California, San Diego, Harvard University, and Leland Stanford Junior University.

What are the main research applications of Cy5.5 based on published literature?

Research on Cy5.5 focuses on nanoplatforms for cancer theranostics, optical imaging and spectroscopy techniques, and S100 proteins and annexins. Notable applications include tumor visualization and intraoperative imaging. A key publication describes tumor paint using a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci, and another discusses visualization of antitumor treatment using annexin V–Cy5.5 conjugates.

Who are the most prolific researchers publishing on Cy5.5?

The leading authors are Andreas Faust and Christoph Bremer, each with 9 publications. Both are affiliated with institutions in Münster. Other prolific researchers include Alexei Bogdanov and Ick Chan Kwon, each with 8 publications, as well as Anna Moore and Carsten Höltke with 7 publications each.

What is the patent landscape for Cy5.5 and recent trends?

The compound is covered by 12,593 patents total, with 7,883 patents filed in the last 3 years. Patent filings peaked in 2024 with 3,593 patents and have continued into 2025 with 2,526 filings. Research papers number 375 in total with 24 publications in the last 3 years. The dominant patent classification is A61K (pharmaceutical compositions) with 7,063 patents, followed by A61P (therapeutic applications) with 6,084 patents.

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