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Credelio

3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide · also: Lotilaner, lotilanerum, Credelio CAT, Lotilaner ophthalmic solution

FormulaC20H14Cl3F6N3O3S
Mol. weight596.7504
PubChem CID76959255
InChIKeyHDKWFBCPLKNOCK-SFHVURJKSA-N
SMILESCC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F
2,446Patents
33Research papers
881Patents - last 3 years
14Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Bayer AG445
2BASF SE342
3Bayer CropScience AG171
4Syngenta Crop Protection AG Switzerland147
5Corteva Agriscience LLC123
6Sumitomo Chemical Co Ltd104
7Intervet International BV92
8Elanco Animal Health GmbH72
9Boehringer Ingelheim Animal Health USA Inc42
10Zoetis Services LLC41

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A01NPreservation of bodies; biocides; pest repellents2,065
2C07DHeterocyclic compounds1,613
3A01PBiocidal activity of chemical compounds1,018
4A61PTherapeutic activity (drug indications)764
5A61KMedicinal preparations571
6C07CAcyclic and carbocyclic compounds252
7Y02AClimate change adaptation229
8A01C109
9C07FOrganometallic compounds103
10C05G91

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Methods for treating demodex blepharitis using lotilaner formulations2023Tarsus Pharmaceuticals Inc3
Methods for treating ocular Demodex using lotilaner formulations2023Tarsus Pharmaceuticals Inc3
Ophthalmic compositions for treating ocular Demodex using lotilaner formulations2023Tarsus Pharmaceuticals Inc1
PROCESS FOR LOTILANER INTERMEDIATE2022Elanco Shanghai Animal Health Co Ltd0
Lotilaner and salts thereof2017ELANCO TIERGESUNDHEIT AG0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Dermatology and Skin Diseases1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Scott WisemanElanco (United States)11
2Daniel E. SnyderDanieli (Italy)6
3Elizabeth YeuVirginia Eye Consultants5
4Lisa YoungElanco (United States)5
5Mark HoldbrookTaro Pharmaceuticals (United States)5
6Stephanie N. BabaTaro Pharmaceuticals (United States)5
7Craig R. ReinemeyerEast Tennessee Clinical Research4
8Claudia Corredor-OrtegaAsociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes3
9Daniela KaradzovskaAustralasia Paediatric Endocrine Group3
10Elizabeth CrawleyElanco (United States)3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical formula and molecular weight of Credelio?

Credelio has the molecular formula C20H14Cl3F6N3O3S and a molecular weight of 596.7504 g/mol. Its canonical chemical name is 3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide.

Which companies hold the most patents related to Credelio?

Bayer AG holds the largest patent portfolio with 445 patents, followed by BASF SE with 342 patents and Bayer CropScience AG with 171 patents. Other significant patent holders include Syngenta Crop Protection AG Switzerland with 147 patents and Corteva Agriscience LLC with 123 patents.

What are the primary medical applications documented for Credelio?

Credelio has documented applications as a topical ophthalmic solution for treating Demodex blepharitis and ocular Demodex infection, as well as a flavored chewable tablet formulation for flea elimination in cats. Recent patents describe ophthalmic compositions and methods for treating ocular Demodex using lotilaner formulations.

Who are the leading authors publishing research on Credelio and what are their affiliations?

Scott Wiseman from Elanco (United States) is the most prolific author with 11 papers on Credelio. Other significant contributors include Daniel E. Snyder from Danieli (Italy) with 6 papers, and Elizabeth Yeu from Virginia Eye Consultants, Lisa Young from Elanco (United States), Mark Holdbrook from Taro Pharmaceuticals (United States), and Stephanie N. Baba from Taro Pharmaceuticals (United States), each with 5 papers.

How has patent activity for Credelio changed in recent years?

Patent activity has grown substantially, with 2020 showing 233 patents, increasing to 429 patents in 2022. Activity remained high with 376 patents in 2023 and 405 patents in 2024. The total patent coverage for Credelio includes 2,446 patents, with 905 filed in the last 3 years.

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