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Lotilaner

3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide · also: Credelio, Xdemvy (TN), lotilanerum, Credelio CAT, Lotilaner ophthalmic solution, (S)-3-Methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxamide

FormulaC20H14Cl3F6N3O3S
Mol. weight596.7504
PubChem CID76959255
InChIKeyHDKWFBCPLKNOCK-SFHVURJKSA-N
SMILESCC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F
2,446Patents
33Research papers
871Patents - last 3 years
14Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Bayer AG445
2BASF SE342
3Bayer CropScience AG171
4Syngenta Crop Protection AG Switzerland147
5Corteva Agriscience LLC123
6Sumitomo Chemical Co Ltd104
7Intervet International BV92
8Elanco Animal Health GmbH72
9Boehringer Ingelheim Animal Health USA Inc42
10Zoetis Services LLC41

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A01NPreservation of bodies; biocides; pest repellents2,065
2C07DHeterocyclic compounds1,613
3A01PBiocidal activity of chemical compounds1,023
4A61PTherapeutic activity (drug indications)764
5A61KMedicinal preparations571
6C07CAcyclic and carbocyclic compounds253
7Y02AClimate change adaptation229
8A01C109
9C07FOrganometallic compounds103
10C05G91

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Methods for treating demodex blepharitis using lotilaner formulations2023Tarsus Pharmaceuticals Inc3
Methods for treating ocular Demodex using lotilaner formulations2023Tarsus Pharmaceuticals Inc3
Ophthalmic compositions for treating ocular Demodex using lotilaner formulations2023Tarsus Pharmaceuticals Inc1
PROCESS FOR LOTILANER INTERMEDIATE2022Elanco Shanghai Animal Health Co Ltd0
Lotilaner and salts thereof2017ELANCO TIERGESUNDHEIT AG0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Dermatology and Skin Diseases1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Scott WisemanElanco (United States)11
2Daniel E. SnyderDanieli (Italy)6
3Elizabeth YeuVirginia Eye Consultants5
4Lisa YoungElanco (United States)5
5Mark HoldbrookTaro Pharmaceuticals (United States)5
6Stephanie N. BabaTaro Pharmaceuticals (United States)5
7Craig R. ReinemeyerEast Tennessee Clinical Research4
8Claudia Corredor-OrtegaAsociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes3
9Daniela KaradzovskaAustralasia Paediatric Endocrine Group3
10Elizabeth CrawleyElanco (United States)3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Lotilaner?

Lotilaner has the molecular formula C20H14Cl3F6N3O3S and a molecular weight of 596.7504 g/mol.

What are the primary commercial names for Lotilaner?

Lotilaner is marketed under several names including Credelio, Xdemvy (TN), and Credelio CAT. It is also available as Lotilaner ophthalmic solution.

Which organizations hold the most patents related to Lotilaner?

The leading patent assignees for Lotilaner-related inventions are Bayer AG with 445 patents, BASF SE with 342 patents, and Bayer CropScience AG with 171 patents. In the animal health sector, Intervet International BV holds 92 patents and Elanco Animal Health GmbH holds 72 patents.

What are the main clinical applications of Lotilaner based on recent research?

Recent publications focus on Lotilaner ophthalmic solution for treating Demodex blepharitis, with pivotal trial results published in 2022 and 2023. Additionally, Lotilaner flavored chewable tablets (Credelio CAT) have been evaluated for flea elimination in cats. Research spans ocular surface treatments and dermatological applications.

How has patent activity for Lotilaner evolved in recent years?

Patent activity increased substantially from 2016 onwards, peaking in 2023 with 376 patents and reaching 405 in 2024. In the last 3 years (2022–2024), 871 patents have been filed related to Lotilaner. The most common patent classifications are A01N (2065 patents) and C07D (1613 patents).

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