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Lotilaner

3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide · also: Credelio · Xdemvy (TN) · lotilanerum · Credelio CAT · Lotilaner ophthalmic solution · (S)-3-Methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxamide

FormulaC20H14Cl3F6N3O3S
Mol. weight596.7504
PubChem CID76959255
InChIKeyHDKWFBCPLKNOCK-SFHVURJKSA-N
SMILESCC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F
2,446Patents
33Research papers
837Patents - last 3 years
14Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Bayer AG592
2BASF SE354
3Sinochem Holdings Corp Ltd149
4Corteva Inc123
5Merck and Co Inc104
6Sumitomo Chemical Co Ltd104
7Elanco Animal Health Inc92
8C.H. Boehringer Sohn AG and Co KG57
9Zoetis Inc41
10Nippon Soda Co Ltd40

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A01NPreservation of bodies; biocides; pest repellents2,065
2C07DHeterocyclic compounds1,617
3A01PBiocidal activity of chemical compounds1,023
4A61PTherapeutic activity (drug indications)766
5A61KMedicinal preparations571
6C07CAcyclic and carbocyclic compounds253
7Y02AClimate change adaptation229
8A01C109
9C07FOrganometallic compounds103
10C05G91

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Methods for treating demodex blepharitis using lotilaner formulations2023Tarsus Pharmaceuticals Inc3
Methods for treating ocular Demodex using lotilaner formulations2023Tarsus Pharmaceuticals Inc3
Ophthalmic compositions for treating ocular Demodex using lotilaner formulations2023Tarsus Pharmaceuticals Inc1
PROCESS FOR LOTILANER INTERMEDIATE2022Elanco Animal Health Inc0
Lotilaner and salts thereof20170

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20202
202114
20222
20234
20244
20256

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Scott WisemanElanco (United States)11
2Daniel E. SnyderDanieli (Italy)6
3Lisa YoungElanco (United States)5
4Elizabeth YeuVirginia Eye Consultants5
5Mark HoldbrookTaro Pharmaceuticals (United States)5
6Stephanie N. BabaTaro Pharmaceuticals (United States)5
7Craig R. ReinemeyerEast Tennessee Clinical Research4
8Kari L. RiggsElanco (United States)3
9Martha Massaro-CorredorAsociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes3
10Juan Carlos CeballosAsociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Lotilaner?

Lotilaner has the molecular formula C20H14Cl3F6N3O3S with a molecular weight of 596.7504. Its canonical chemical name is 3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide, and it is also known by brand names including Credelio and Xdemvy.

Which companies hold the most patents related to Lotilaner?

The leading patent assignees for Lotilaner are Bayer AG with 592 patents, BASF SE with 354 patents, and Sinochem Holdings Corp Ltd with 149 patents. Other significant patent holders include Corteva Inc, Merck and Co Inc, and Sumitomo Chemical Co Ltd, each holding over 100 patents.

What are the main medical applications of Lotilaner based on recent patents and publications?

Recent patents and papers indicate two primary applications: treatment of demodex blepharitis and ocular Demodex using ophthalmic formulations, and flea elimination in companion animals using flavored chewable tablets. Patents from Tarsus Pharmaceuticals Inc describe methods for treating demodex blepharitis with lotilaner formulations, while papers document clinical trials for the ophthalmic solution and field studies assessing efficacy in cats.

How has patent activity for Lotilaner evolved over time?

Patent activity has grown substantially, with 19 patents in 2016 rising to 405 in 2024. Notable increases occurred in 2020–2022, peaking at 429 patents in 2022. Recent years show 837 patents filed in the last three years. Academic publications have also increased, with 14 papers published in 2021 and ongoing output in 2024–2025.

What are the primary patent classification areas for Lotilaner?

The most prevalent CPC classifications are A01N (2065 patents), covering pesticidal compounds, followed by C07D (1617 patents) for heterocyclic compounds, and A01P (1023 patents) for biocidal activity. Significant coverage also exists in A61P (766 patents) for therapeutic activity and A61K (571 patents) for medicinal preparations, reflecting both agricultural and pharmaceutical applications.

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